Cardiac AAV9 Gene Delivery Strategies in Adult Canines: Assessment by Long-term Serial SPECT Imaging of Sodium Iodide Symporter Expression. (scientific article published on 27 April 2015)

Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure

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Normalisation to blood activity is required for the accurate quantification of Na/I symporter ectopic expression by SPECT/CT in individual subjects

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Optimized delivery system achieves enhanced endomyocardial stem cell retention

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Rescuing the failing heart by targeted gene transfer

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Analysis of AAV serotypes 1-9 mediated gene expression and tropism in mice after systemic injection

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Robust systemic transduction with AAV9 vectors in mice: efficient global cardiac gene transfer superior to that of AAV8.

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A potential role of distinctively delayed blood clearance of recombinant adeno-associated virus serotype 9 in robust cardiac transduction

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Percutaneous transendocardial delivery of self-complementary adeno-associated virus 6 achieves global cardiac gene transfer in canines.

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Long-term restoration of cardiac dystrophin expression in golden retriever muscular dystrophy following rAAV6-mediated exon skipping

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Non-invasive radioiodine imaging for accurate quantitation of NIS reporter gene expression in transplanted hearts

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Intramyocardial VEGF-B167 gene delivery delays the progression towards congestive failure in dogs with pacing-induced dilated cardiomyopathy

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Long-term robust myocardial transduction of the dog heart from a peripheral vein by adeno-associated virus serotype-8.

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A single intravenous injection of adeno-associated virus serotype-9 leads to whole body skeletal muscle transduction in dogs.

Q37245439

The biology of the sodium iodide symporter and its potential for targeted gene delivery

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Non-invasive imaging of cardiac transgene expression with PET: comparison of the human sodium/iodide symporter gene and HSV1-tk as the reporter gene

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Cardiac reporter gene imaging using the human sodium/iodide symporter gene.

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Kinetics of perrhenate uptake and comparative biodistribution of perrhenate, pertechnetate, and iodide by NaI symporter-expressing tissues in vivo.

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Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors

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Force relaxation and thin filament protein phosphorylation during acute myocardial ischemia

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Rapid, simple, and versatile manufacturing of recombinant adeno-associated viral vectors at scale.

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Augmentation of left ventricular mechanics by recirculation-mediated AAV2/1-SERCA2a gene delivery in experimental heart failure

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Immunity to adeno-associated virus-mediated gene transfer in a random-bred canine model of Duchenne muscular dystrophy

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Recombinant adeno-associated virus serotype 9 leads to preferential cardiac transduction in vivo

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Efficient transduction of skeletal muscle using vectors based on adeno-associated virus serotype 6.

Q45571369

Soluble TNF-α receptor secretion from healthy or dystrophic mice after AAV6-mediated muscle gene transfer

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Percutaneous cardiac recirculation-mediated gene transfer of an inhibitory phospholamban peptide reverses advanced heart failure in large animals

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Transendocardial delivery of AAV6 results in highly efficient and global cardiac gene transfer in rhesus macaques

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Recirculating cardiac delivery of AAV2/1SERCA2a improves myocardial function in an experimental model of heart failure in large animals

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Accuracy of myocardial sodium/iodide symporter gene expression imaging with radioiodide: evaluation with a dual-gene adenovirus vector.

Q50772831

Sodium iodide symporter (hNIS) permits molecular imaging of gene transduction in cardiac transplantation.

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Feasibility of tomographic 99mTc-hexakis-2-methoxy-2-methylpropyl-isonitrile imaging for the assessment of myocardial area at risk and the effect of treatment in acute myocardial infarction

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P433

issue

P304

page(s)

1211-1221

P577

publication date

2015-04-27

P1433

published in

Molecular Therapy

Q15762400

P1476

title

Cardiac AAV9 Gene Delivery Strategies in Adult Canines: Assessment by Long-term Serial SPECT Imaging of Sodium Iodide Symporter Expression

P478

volume

Reverse relations

cites work (P2860)

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Q92378330	Molecular Imaging of the Heart
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Q40445316	Production and Characterization of Vectors Based on the Cardiotropic AAV Serotype 9.