Boolean Modeling Reveals the Necessity of Transcriptional Regulation for Bistability in PC12 Cell Differentiation

scientific article published on 14 April 2016

Boolean Modeling Reveals the Necessity of Transcriptional Regulation for Bistability in PC12 Cell Differentiation is …
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scholarly articleQ13442814

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P356DOI10.3389/FGENE.2016.00044
P8608Fatcat IDrelease_2goxhlgrcrdrpnumke72qkomr4
P932PMC publication ID4830832
P698PubMed publication ID27148350

P50authorMelanie BoerriesQ40933230
Hauke BuschQ50053350
P2093author name stringAmit Singh
Martin Klose
Steffen Knauer
Silke Kowar
Barbara Offermann
María L Fernández-Cachón
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Expression of the urokinase plasminogen activator receptor is transiently required during "priming" of PC12 cells in nerve growth factor-directed cellular differentiationQ46780216
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Single-cell heterogeneity in suppression of PC12 differentiation by direct microinjection of a differentiation inhibitor, U0126.Q54355025
Multiple signaling conduits regulate global differentiation-specific gene expression in PC12 cells.Q54700092
PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiationQ57270016
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Prediction and validation of the distinct dynamics of transient and sustained ERK activationQ81581176
Plasminogen activator inhibitor-1 aids nerve growth factor-induced differentiation and survival of pheochromocytoma cells by activating both the extracellular signal-regulated kinase and c-Jun pathwaysQ83294239
Timing-dependent actions of NGF required for cell differentiationQ33528983
Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transductionQ33668279
Clustering gene expression patternsQ33882299
Down-regulation of Sp1 suppresses cell proliferation, clonogenicity and the expressions of stem cell markers in nasopharyngeal carcinoma.Q34042615
Interactions of multiple signaling pathways in neuropeptide Y-mediated bimodal vascular smooth muscle cell growthQ34072897
Studying and modelling dynamic biological processes using time-series gene expression dataQ34340507
Boolean approach to signalling pathway modelling in HGF-induced keratinocyte migrationQ34409663
The p38/MK2-driven exchange between tristetraprolin and HuR regulates AU-rich element-dependent translationQ34426626
A network of immediate early gene products propagates subtle differences in mitogen-activated protein kinase signal amplitude and duration.Q34551716
Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF.Q34576586
Label-free detection of neuronal differentiation in cell populations using high-throughput live-cell imaging of PC12 cellsQ34602505
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Cell fate decisions are specified by the dynamic ERK interactomeQ35014377
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Global expression analysis identified a preferentially nerve growth factor-induced transcriptional program regulated by sustained mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) and AP-1 protein activation during PC12 ceQ35639929
Frequency modulation of ERK activation dynamics rewires cell fateQ36349325
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Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signalsQ36707930
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Identification of diverse nerve growth factor-regulated genes by serial analysis of gene expression (SAGE) profiling.Q37245857
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MEK1-dependent delayed expression of Fos-related antigen-1 counteracts c-Fos and p65 NF-kappaB-mediated interleukin-8 transcription in response to cytokines or growth factorsQ38332773
Receptor Level Mechanisms Are Required for Epidermal Growth Factor (EGF)-stimulated Extracellular Signal-regulated Kinase (ERK) Activity PulsesQ38841110
Stochastic ERK activation induced by noise and cell-to-cell propagation regulates cell density-dependent proliferationQ39076730
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Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylationQ39631004
The nerve growth factor 35 years laterQ39667849
Temporal and functional dynamics of the transcriptome during nerve growth factor-induced differentiation.Q40001677
An E2F1-dependent gene expression program that determines the balance between proliferation and cell deathQ40029015
Bach2 is involved in neuronal differentiation of N1E-115 neuroblastoma cellsQ40288843
Functional interactions of Raf and MEK with Jun-N-terminal kinase (JNK) result in a positive feedback loop on the oncogenic Ras signaling pathwayQ40387396
P4510describes a project that usesImageJQ1659584
CytoscapeQ3699942
P407language of work or nameEnglishQ1860
P921main subjectcell differentiationQ210861
P304page(s)44
P577publication date2016-04-14
P1433published inFrontiers in GeneticsQ2499875
P1476titleBoolean Modeling Reveals the Necessity of Transcriptional Regulation for Bistability in PC12 Cell Differentiation
P478volume7

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cites work (P2860)
Q38806418An immediate-late gene expression module decodes ERK signal duration
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Q58928293Information Theoretic Concepts to Unravel Cell–Cell Communication
Q47103516Specific role of RhoC in tumor invasion and metastasis

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