Enhancement of rabbit jugular vein thrombolysis by neutralization of factor XI. In vivo evidence for a role of factor XI as an anti-fibrinolytic factor

scientific article published on January 1998

Enhancement of rabbit jugular vein thrombolysis by neutralization of factor XI. In vivo evidence for a role of factor XI as an anti-fibrinolytic factor is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI781
P932PMC publication ID508534
P698PubMed publication ID9421460
P5875ResearchGate publication ID13809722

P2093author name stringBouma BN
Meijers JC
Levi M
ten Cate H
Hack CE
Minnema MC
Biemond BJ
Friederich PW
Mosnier LO
von dem Borne PA
P2860cites workPlasma carboxypeptidases as regulators of the plasminogen systemQ24677226
TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complexQ28281969
Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitorsQ28294390
Activation and characterization of procarboxypeptidase B from human plasmaQ28300347
Tissue factor and hemostasisQ28630773
The tissue factor pathway: how it has become a "prima ballerina"Q28631248
Purification and characterization of TAFI, a thrombin-activable fibrinolysis inhibitorQ34059019
Factor XI deficiency in Ashkenazi Jews in IsraelQ34118794
The coagulation-kinin pathway of human plasmaQ34687103
Thrombin-mediated activation of factor XI results in a thrombin-activatable fibrinolysis inhibitor-dependent inhibition of fibrinolysisQ39784189
An intrinsic factor XII- prekallikrein-dependent pathway activates the human plasma renin-angiotensin systemQ41700499
Naturally occurring human antibodies against two distinct functional domains in the heavy chain of FXI/FXIa.Q46398550
Evidence suggestive of activation of the intrinsic pathway of blood coagulation after injection of factor Xa/phospholipid into rabbitsQ46707845
Factor XIa induced activation of the intrinsic cascade in vivo.Q52845859
Rabbit blood coagulation factor XI. Purification and propertiesQ57741003
Dental surgery in patients with severe factor XI deficiency without plasma replacementQ67918855
Comparison of bleeding tendency, factor XI coagulant activity, and factor XI antigen in 25 factor XI-deficient kindredsQ69865005
Comparison of sustained antithrombotic effects of inhibitors of thrombin and factor Xa in experimental thrombosisQ71046994
Effect of heparin on the activation of factor XI by fibrin-bound thrombinQ71709876
Feedback activation of factor XI by thrombin in plasma results in additional formation of thrombin that protects fibrin clots from fibrinolysisQ71789536
Factor XI deficiencyQ72595231
The influence of fibrinogen and fibrin on thrombin generation--evidence for feedback activation of the clotting system by clot bound thrombinQ72653551
On the mechanism of the antifibrinolytic activity of plasma carboxypeptidase BQ73363110
The partial thromboplastin time with kaolin. A simple screening test for first stage plasma clotting factor deficienciesQ78981048
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectthrombolysisQ1931577
P304page(s)10-14
P577publication date1998-01-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleEnhancement of rabbit jugular vein thrombolysis by neutralization of factor XI. In vivo evidence for a role of factor XI as an anti-fibrinolytic factor
P478volume101

Reverse relations

cites work (P2860)
Q35081838Activated protein C resistance (FV(Leiden)) and thrombosis: factor V mutations causing hypercoagulable states
Q40603732Activation of coagulation factor XI, without detectable contact activation in dengue haemorrhagic fever.
Q28564560Adjuvant effect of antibodies against von Willebrand Factor, fibrinogen, and fibronectin on staphylokinase-induced thrombolysis as measured using mural thrombi formed in rat mesenteric venules
Q33902731An inhibitor of activated thrombin-activatable fibrinolysis inhibitor potentiates tissue-type plasminogen activator-induced thrombolysis in a rabbit jugular vein thrombolysis model
Q37739907Antithrombotic therapy in acute coronary syndrome: how far up the coagulation cascade will we go?
Q34376924Basic principles in thrombolysis: regulatory role of plasminogen
Q37095385Beta 2-Glycoprotein I binds factor XI and inhibits its activation by thrombin and factor XIIa: loss of inhibition by clipped beta 2-glycoprotein I.
Q35574076Can the time window for administration of thrombolytics in stroke be increased?
Q44314786Carboxypeptidase B inhibitors reduce tissue factor-induced renal microthrombi in rats
Q35208114Carboxypeptidase U (TAFIa): a new drug target for fibrinolytic therapy?
Q34211617Carboxypeptidase U at the interface between coagulation and fibrinolysis
Q37781402Coagulation factor XI as a novel target for antithrombotic treatment.
Q33814642Combination treatment with VELCADE and low-dose tissue plasminogen activator provides potent neuroprotection in aged rats after embolic focal ischemia
Q35575101Contact pathway of coagulation and inflammation
Q28543133Creating novel activated factor XI inhibitors through fragment based lead generation and structure aided drug design
Q24315027Crystal structures of the FXIa catalytic domain in complex with ecotin mutants reveal substrate-like interactions
Q79366427Deficiency in thrombin-activatable fibrinolysis inhibitor (TAFI) protected mice from ferric chloride-induced vena cava thrombosis
Q39117235Differential Roles for the Coagulation Factors XI and XII in Regulating the Physical Biology of Fibrin.
Q50096411Discovery of thrombin activatable fibrinolysis inhibitor (TAFI).
Q30843513Enhanced endogenous thrombolysis induced by a specific factor Xa inhibitor, DX-9065a, evaluated in a rat arterial thrombolysis model in vivo.
Q27024190Factor XI and contact activation as targets for antithrombotic therapy
Q37033749Factor XI as a Therapeutic Target.
Q26865096Future prospects for contact factors as therapeutic targets
Q46688667In vitro, antithrombotic and bleeding time studies of BMS-654457, a small-molecule, reversible and direct inhibitor of factor XIa.
Q39739972In vivo regulation of plasminogen function by plasma carboxypeptidase B.
Q40167914Inhibition of Factor XII-Mediated Activation of Factor XI Provides Protection Against Experimental Acute Ischemic Stroke in Mice.
Q38117742Insights into thrombin activatable fibrinolysis inhibitor function and regulation.
Q53782006Is resistance futile? The role of activated thrombin-activatable fibrinolysis inhibitor resistance in bleeding in factor XI deficiency.
Q37207774Low thrombin activatable fibrinolysis inhibitor activity levels are associated with an increased risk of a first myocardial infarction in men
Q36562568P1 and P2' site mutations convert protease nexin-2 from a factor XIa inhibitor to a plasmin inhibitor
Q37071138Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI
Q73472411Proteolytic activation of purified human procarboxypeptidase U
Q44365963Stabilization versus inhibition of TAFIa by competitive inhibitors in vitro
Q37124827Survival advantage of coagulation factor XI-deficient mice during peritoneal sepsis
Q28508572Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis
Q41863794The effects of intrinsic pathway protease deficiencies on plasminogen-deficient mice
Q36106323The kunitz protease inhibitor domain of protease nexin-2 inhibits factor XIa and murine carotid artery and middle cerebral artery thrombosis
Q37853060The many faces of the contact pathway and their role in thrombosis
Q36124038The neurovascular unit and combination treatment strategies for stroke
Q36606627Thrombin activatable fibrinolysis inhibitor (TAFI)--how does thrombin regulate fibrinolysis?
Q34786346Thrombin-activatable fibrinolysis inhibitor (TAFI) deficiency is compatible with murine life
Q34215746Thrombin-activatable fibrinolysis inhibitor (TAFI, plasma procarboxypeptidase B, procarboxypeptidase R, procarboxypeptidase U).
Q36384872Thrombin-thrombomodulin connects coagulation and fibrinolysis: more than an in vitro phenomenon

Search more.