Clozapine protects PC-12 cells from death due to oxidative stress induced by hydrogen peroxide via a cell-type specific mechanism involving inhibition of extracellular signal-regulated kinase phosphorylation

scientific article

Clozapine protects PC-12 cells from death due to oxidative stress induced by hydrogen peroxide via a cell-type specific mechanism involving inhibition of extracellular signal-regulated kinase phosphorylation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BRAINRES.2009.05.063
P932PMC publication ID2881214
P698PubMed publication ID19501068
P5875ResearchGate publication ID26271108

P2093author name stringColin J Saldanha
Brian C Magliaro
P2860cites workOxidative stress in psychiatric disorders: evidence base and therapeutic implicationsQ28265319
Protective effects of atypical antipsychotic drugs on PC12 cells after serum withdrawalQ28582269
Preventing severe mental illnesses--new prospects and ethical challengesQ30998369
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Propofol attenuates oxidative stress-induced PC12 cell injury via p38 MAP kinase dependent pathwayQ33291282
The early stages of schizophrenia: speculations on pathogenesis, pathophysiology, and therapeutic approachesQ34463416
Neuroprotective agents in schizophrenia and affective disordersQ36458436
Prevention of oxidative stress-mediated neuropathology and improved clinical outcome by adjunctive use of a combination of antioxidants and omega-3 fatty acids in schizophreniaQ36508050
Schizophrenia susceptibility genes converge on interlinked pathways related to glutamatergic transmission and long-term potentiation, oxidative stress and oligodendrocyte viability.Q36536954
Mechanisms of cell death in oxidative stressQ36658125
Haloperidol and clozapine differentially affect the expression of arrestins, receptor kinases, and extracellular signal-regulated kinase activationQ37068695
D2/D3 receptor agonist ropinirole protects dopaminergic cell line against rotenone-induced apoptosis through inhibition of caspase- and JNK-dependent pathways.Q40017852
Melatonin protects against hydrogen peroxide-induced cell death signaling in SH-SY5Y cultured cells: involvement of nuclear factor kappa B, Bax and Bcl-2.Q40249619
MKP-1 contributes to oxidative stress-induced apoptosis via inactivation of ERK1/2 in SH-SY5Y cellsQ40351131
Activation of ERK1/2, JNK and PKB by hydrogen peroxide in human SH-SY5Y neuroblastoma cells: role of ERK1/2 in H2O2-induced cell deathQ40598528
Dopaminergic regulation of dopamine release from PC12 cells via a pertussis toxin-sensitive G proteinQ41699050
Amitriptyline and fluoxetine protect PC12 cells from cell death induced by hydrogen peroxideQ42726469
Olanzapine protects PC12 cells from oxidative stress induced by hydrogen peroxideQ44516603
Opposite regulation by typical and atypical anti-psychotics of ERK1/2, CREB and Elk-1 phosphorylation in mouse dorsal striatumQ44519012
Clozapine and the mitogen-activated protein kinase signal transduction pathway: implications for antipsychotic actionsQ46394544
Differential profile of antipsychotics at serotonin 5-HT1A and dopamine D2S receptors coupled to extracellular signal-regulated kinaseQ46959886
D2-Like dopamine autoreceptor activation reduces quantal size in PC12 cells.Q47285061
Oxidative-antioxidative systems and their relation with serum S100 B levels in patients with schizophrenia: effects of short term antipsychotic treatmentQ48188469
Oxidative stress in prefrontal cortex of rat exposed to MK-801 and protective effects of CAPE.Q48234285
Biomarkers of oxidative stress in schizophrenic and control subjects.Q51771962
Induction of c-fos, jun B and egr-1 expression by haloperidol in PC12 cells: involvement of calciumQ71760123
[Oxidative stress involvement in schizophrenia pathophysiology: a review]Q80117112
Role of the JAK-STAT pathway in protection of hydrogen peroxide preconditioning against apoptosis induced by oxidative stress in PC12 cellsQ82880471
P4510describes a project that usesImageJQ1659584
P921main subjectphosphorylationQ242736
P304page(s)14-24
P577publication date2009-06-06
P1433published inBrain ResearchQ4955782
P1476titleClozapine protects PC-12 cells from death due to oxidative stress induced by hydrogen peroxide via a cell-type specific mechanism involving inhibition of extracellular signal-regulated kinase phosphorylation
P478volume1283

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cites work (P2860)
Q96127613Clozapine modulates retinoid homeostasis in human brain and normalizes serum retinoic acid deficit in patients with schizophrenia
Q33833421Compositional Characteristics and In Vitro Evaluations of Antioxidant and Neuroprotective Properties of Crude Extracts of Fucoidan Prepared from Compressional Puffing-Pretreated Sargassum crassifolium
Q50435618Design, synthesis and evaluation of novel cinnamic acid derivatives bearing N-benzyl pyridinium moiety as multifunctional cholinesterase inhibitors for Alzheimer's disease
Q27012948Effect of atypical antipsychotics on fetal growth: is the placenta involved?
Q47788587Exploratory investigation of biomarker candidates for suicide in schizophrenia and bipolar disorder
Q37187021Homocysteine levels in patients with schizophrenia on clozapine monotherapy
Q48858353Inducing-apoptotic activity of the ethanol extract of Duchesnea indica Focke on treatment of herpes simplex encephalitis
Q39552320Neuroprotection of paliperidone on SH-SY5Y cells against β-amyloid peptide(25-35), N-methyl-4-phenylpyridinium ion, and hydrogen peroxide-induced cell death.
Q48565826Protective activity of the ethanol extract of Cynanchum paniculatum (BUNGE) Kitagawa on treating herpes simplex encephalitis
Q39771227The Atypical Antipsychotic Agent, Clozapine, Protects Against Corticosterone-Induced Death of PC12 Cells by Regulating the Akt/FoxO3a Signaling Pathway
Q35006087U0126 protects cells against oxidative stress independent of its function as a MEK inhibitor
Q41173500Uric acid levels in patients with schizophrenia on clozapine monotherapy

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