A novel photoaffinity ligand for the dopamine transporter based on pyrovalerone

scientific article

A novel photoaffinity ligand for the dopamine transporter based on pyrovalerone is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BMC.2009.04.057
P932PMC publication ID2696686
P698PubMed publication ID19442525
P5875ResearchGate publication ID24427608

P2093author name stringJames D Foster
Yurong Huang
Christopher K Surratt
Roxanne A Vaughan
John R Lever
David J Lapinsky
Shaili Aggarwal
P2860cites workPhotoaffinity labeling and its application in structural biologyQ36739857
Labeling of dopamine transporter transmembrane domain 1 with the tropane ligand N-[4-(4-azido-3-[125I]iodophenyl)butyl]-2beta-carbomethoxy-3beta-(4-chlorophenyl)tropane implicates proximity of cocaine and substrate active sitesQ40021147
Novel azido and isothiocyanato analogues of [3-(4-phenylalkylpiperazin-1-yl)propyl]bis(4-fluorophenyl)amines as potential irreversible ligands for the dopamine transporter.Q40465110
Novel tropane-based irreversible ligands for the dopamine transporterQ40765837
Dopamine transport sites selectively labeled by a novel photoaffinity probe: 125I-DEEP.Q42198941
Design, synthesis, and characterization of a novel, 4-[2-(diphenylmethoxy)ethyl]-1-benzyl piperidine-based, dopamine transporter photoaffinity labelQ43567814
The uptake inhibitors cocaine and benztropine differentially alter the conformation of the human dopamine transporterQ43632105
Structure-activity relationship comparison of (S)-2beta-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes and (R)-2beta-substituted 3beta-(3,4-dichlorophenyl)tropanes at the dopamine transporterQ44490853
Characterization of the cocaine binding site on the sigma-1 receptorQ46151664
Radioiodinated azide and isothiocyanate derivatives of cocaine for irreversible labeling of dopamine transporters: synthesis and covalent binding studiesQ46494576
Synthesis of substituted 3-carbamoylecgonine methyl ester analogues: irreversible and photoaffinity ligands for the cocaine receptor/dopamine transporterQ48089850
Localization of cocaine analog [125I]RTI 82 irreversible binding to transmembrane domain 6 of the dopamine transporterQ48626694
Photoaffinity labeling of the dopamine reuptake carrier protein with 3-azido[3H]GBR-12935.Q48747019
Differential binding of tropane-based photoaffinity ligands on the dopamine transporter.Q51482208
Photoaffinity labeling of the mammalian dopamine transporterQ69781972
1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitorsQ24645072
The search for medications to treat stimulant dependenceQ24655160
Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reactionQ27860958
Isothiocyanate derivatives of 9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole): irreversible ligands for the dopamine transporterQ28259470
Dopamine transporter ligands: recent developments and therapeutic potentialQ28266714
Affinity labeling the dopamine transporter ligand binding siteQ28567902
Design and synthesis of a novel photoaffinity ligand for the dopamine and serotonin transporters based on 2beta-carbomethoxy-3beta-biphenyltropane.Q30357631
Probes for the cocaine receptor. Potentially irreversible ligands for the dopamine transporterQ33987010
Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residueQ34416712
New insights into the mechanism of action of amphetaminesQ34599276
Pharmacotherapy for methamphetamine dependence: a review of the pathophysiology of methamphetamine addiction and the theoretical basis and efficacy of pharmacotherapeutic interventionsQ34797086
Interaction of cocaine-, benztropine-, and GBR12909-like compounds with wild-type and mutant human dopamine transporters: molecular features that differentially determine antagonist-binding properties.Q34825605
Neurobiology of cocaine abuseQ36208834
Irreversible binding of a novel phenylisothiocyanate tropane analog to monoamine transporters in rat brainQ36429668
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)3770-3774
P577publication date2009-05-03
P1433published inBioorganic & Medicinal ChemistryQ2904200
P1476titleA novel photoaffinity ligand for the dopamine transporter based on pyrovalerone
P478volume17

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cites work (P2860)
Q40079534(±)-2-(N-tert-Butylamino)-3'-[(125)I]-iodo-4'-azidopropiophenone: a dopamine transporter and nicotinic acetylcholine receptor photoaffinity ligand based on bupropion (Wellbutrin, Zyban).
Q34153285Azido-iodo-N-benzyl derivatives of threo-methylphenidate (Ritalin, Concerta): Rational design, synthesis, pharmacological evaluation, and dopamine transporter photoaffinity labeling
Q34306186Evolution of a Compact Photoprobe for the Dopamine Transporter Based on (±)-threo-Methylphenidate
Q28596136From linked open data to molecular interaction: studying selectivity trends for ligands of the human serotonin and dopamine transporter
Q35891263Novel Azido-Iodo Photoaffinity Ligands for the Human Serotonin Transporter Based on the Selective Serotonin Reuptake Inhibitor (S)-Citalopram

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