CaMKII as a pathological mediator of ER stress, oxidative stress, and mitochondrial dysfunction in a murine model of nephronophthisis

scientific article

CaMKII as a pathological mediator of ER stress, oxidative stress, and mitochondrial dysfunction in a murine model of nephronophthisis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPRENAL.00426.2015
P8608Fatcat IDrelease_c36p2nzhxvahvmbuddtz5srxri
P698PubMed publication ID27076647

P2093author name stringHervé Husson
Oxana Ibraghimov-Beskrovnaya
Philippe Beauverger
Philip Janiak
Olivier Duclos
Ryan J Russo
Steven R Ledbetter
Nikolay O Bukanov
Thomas A Natoli
Kelly A Rogers
Christina Bracken
P2860cites workExome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signalingQ24294774
NEK8 mutations affect ciliary and centrosomal localization and may cause nephronophthisisQ24306642
Polycystin-2 down-regulates cell proliferation via promoting PERK-dependent phosphorylation of eIF2alphaQ24318555
Autosomal dominant polycystic kidney disease: the last 3 yearsQ24656249
Mechanisms of CaMKII action in long-term potentiationQ26998387
The role of the cilium in normal and abnormal cell cycles: emphasis on renal cystic pathologiesQ27026481
THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in ciliaQ28505803
Impaired Wnt-beta-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathyQ28506100
Increased hedgehog signaling in postnatal kidney results in aberrant activation of nephron developmental programsQ28588215
Aberrant Wnt signalling and cellular over-proliferation in a novel mouse model of Meckel-Gruber syndromeQ28591420
CaMKII determines mitochondrial stress responses in heartQ28591986
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stressQ29615495
Effects of lovastatin treatment on the metabolic distributions in the Han:SPRD rat model of polycystic kidney diseaseQ30658399
Nephronophthisis: disease mechanisms of a ciliopathyQ33594278
Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney diseaseQ33914623
Inflammation, Oxidative Stress, and Insulin Resistance in Polycystic Kidney DiseaseQ34497281
Cyclic AMP-mediated cyst expansionQ34850793
Roles of oxidative stress and antioxidant therapy in chronic kidney disease and hypertensionQ35748416
Kidney injury accelerates cystogenesis via pathways modulated by heme oxygenase and complementQ36050899
Apoptosis and loss of renal tissue in polycystic kidney diseasesQ36707140
Polycystic kidney disease: genes, proteins, animal models, disease mechanisms and therapeutic opportunitiesQ36707529
Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy.Q37092766
Endoplasmic reticulum stress in the kidneyQ37184493
Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase IIQ37210184
Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways.Q37363053
8-hydroxy-2' -deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesisQ37468730
The role of CaMKII regulation of phospholamban activity in heart diseaseQ37555074
Endoplasmic reticulum stress as a progression factor for kidney injuryQ37666123
Whole-exome resequencing distinguishes cystic kidney diseases from phenocopies in renal ciliopathiesQ37678462
Impact of Mammalian Target of Rapamycin Inhibition on Autosomal-Dominant Polycystic Kidney DiseaseQ37811516
Polycystic kidney disease: pathogenesis and potential therapiesQ37819164
CaMKII in myocardial hypertrophy and heart failureQ37833230
Controlling the cell cycle: the role of calcium/calmodulin-stimulated protein kinases I and II.Q37837372
Analysis of CaM-kinase signaling in cellsQ37870268
Autosomal dominant polycystic kidney disease: recent advances in pathogenesis and potential therapiesQ38063460
CaMKII inhibitors: from research tools to therapeutic agentsQ38193798
Mitochondrial analysis in living cells: the use of rhodamine 123 and flow cytometryQ39479961
The γ-secretase cleavage product of polycystin-1 regulates TCF and CHOP-mediated transcriptional activation through a p300-dependent mechanismQ40619026
Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse modelsQ40899081
CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD.Q41787735
Everolimus in patients with autosomal dominant polycystic kidney disease.Q43004249
Sirolimus and kidney growth in autosomal dominant polycystic kidney diseaseQ43004251
CaMK-II is a PKD2 target that promotes pronephric kidney development and stabilizes ciliaQ43986243
Characterization of diabetic nephropathy in CaM kinase IIalpha (Thr286Asp) transgenic mice.Q46205784
A novel model of insulin-dependent diabetes with renal and retinal lesions by transgenic expression of CaMKIIalpha (Thr286Asp) in pancreatic beta-cellsQ46541900
Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine.Q52575181
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectmurine modelQ122890741
P304page(s)F1414-22
P577publication date2016-04-13
P1433published inAmerican Journal of Physiology - Renal PhysiologyQ2610177
P1476titleCaMKII as a pathological mediator of ER stress, oxidative stress, and mitochondrial dysfunction in a murine model of nephronophthisis
P478volume310

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cites work (P2860)
Q39056528CaMKII is a nodal signal for multiple programmed cell death pathways in heart
Q47281633CaMKII is involved in subcellular Ca2+ redistribution-induced endoplasmic reticulum stress leading to apoptosis in primary cultures of rat proximal tubular cells exposed to lead
Q48335945Coenzyme Q10 Prevents Mitochondrial Dysfunction and Facilitates Pharmacological Activity of Atorvastatin in 6-OHDA Induced Dopaminergic Toxicity in Rats
Q37214854Endoplasmic reticulum stress and calcium imbalance are involved in cadmium-induced lipid aberrancy in Saccharomyces cerevisiae
Q92068053Imbalanced mitochondrial function provokes heterotaxy via aberrant ciliogenesis
Q90399937Oxidative Stress and Mitochondrial Abnormalities Contribute to Decreased Endothelial Nitric Oxide Synthase Expression and Renal Disease Progression in Early Experimental Polycystic Kidney Disease
Q50912952Role of CaMKII in free fatty acid/hyperlipidemia-induced cardiac remodeling both in vitro and in vivo.
Q97637714The oral Ca/calmodulin-dependent kinase II inhibitor RA608 improves contractile function and prevents arrhythmias in heart failure

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