Quercetin prevents LPS-induced high-mobility group box 1 release and proinflammatory function

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Quercetin prevents LPS-induced high-mobility group box 1 release and proinflammatory function is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1165/RCMB.2008-0119OC
P8608Fatcat IDrelease_asnwdc5glberbmdxcxj6ialyhm
P932PMC publication ID2784404
P698PubMed publication ID19265175

P50authorHaichao WangQ37375045
Michael T LotzeQ89121415
P2093author name stringDaolin Tang
Rui Kang
Weimin Xiao
Xianzhong Xiao
Huali Zhang
P2860cites workStructural basis for the proinflammatory cytokine activity of high mobility group box 1Q24302496
Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoformsQ24312029
The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathwayQ24538824
Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and StaurosporineQ27628650
Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of careQ27860820
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Induction of autophagy and inhibition of tumorigenesis by beclin 1Q28131718
Release of chromatin protein HMGB1 by necrotic cells triggers inflammationQ28131815
HMG-1 as a late mediator of endotoxin lethality in miceQ28139166
A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1Q28220038
High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenalQ28242907
Toll-like receptor 4 is a sensor for autophagy associated with innate immunityQ28513852
RAGE is the major receptor for the proinflammatory activity of HMGB1 in rodent macrophagesQ28568915
The high mobility group (HMG) boxes of the nuclear protein HMG1 induce chemotaxis and cytoskeleton reorganization in rat smooth muscle cellsQ28570659
High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytesQ28574795
The epidemiology of sepsis in the United States from 1979 through 2000Q29547760
Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosisQ29614481
Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGEQ29620722
Potential therapeutic applications of autophagyQ29622862
Small molecule regulators of autophagy identified by an image-based high-throughput screenQ33306309
Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammationQ34156078
Shock and tissue injury induced by recombinant human cachectinQ34189904
The IKK/NF-kappa B pathwayQ34487840
Reversing established sepsis with antagonists of endogenous high-mobility group box 1.Q35122534
The enigma of sepsisQ35202458
The aqueous extract of a popular herbal nutrient supplement, Angelica sinensis, protects mice against lethal endotoxemia and sepsisQ35579574
Hydrogen peroxide stimulates macrophages and monocytes to actively release HMGB1Q35659672
The anti-inflammatory effects of heat shock protein 72 involve inhibition of high-mobility-group box 1 release and proinflammatory function in macrophagesQ35990429
Nuclear heat shock protein 72 as a negative regulator of oxidative stress (hydrogen peroxide)-induced HMGB1 cytoplasmic translocation and releaseQ35990434
A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA.Q35990737
HMGB1: guiding immunity from withinQ36174866
Role of HMGB1 in apoptosis-mediated sepsis lethalityQ36228722
Animal models of sepsis: setting the stageQ36285943
Hmgb-1 as a therapeutic target for infectious and inflammatory disorders.Q36348485
Tyrosine phosphorylation of mitogen-activated protein kinases is necessary for activation of murine macrophages by natural and synthetic bacterial productsQ36361592
Activation of Raf-1 and mitogen-activated protein kinase in murine macrophages partially mimics lipopolysaccharide-induced signaling eventsQ36365140
The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusionQ36403403
The role of high mobility group box-1 protein in severe sepsisQ36462968
High mobility group box protein 1: an endogenous signal for dendritic cell maturation and Th1 polarizationQ38339803
HMGB1 develops enhanced proinflammatory activity by binding to cytokines.Q40016396
Quercetin 3-O-beta-(2''-galloyl)-glucopyranoside inhibits endotoxin LPS-induced IL-6 expression and NF-kappa B activation in macrophagesQ40081165
The inhibition of LPS-induced production of inflammatory cytokines by HSP70 involves inactivation of the NF-kappaB pathway but not the MAPK pathwaysQ40243061
The inhibitory effect of quercetin on IL-6 production by LPS-stimulated neutrophils.Q40356859
Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia.Q40371518
Heat shock response inhibits release of high mobility group box 1 protein induced by endotoxin in murine macrophagesQ40434256
Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 proteinQ40609759
IFN-gamma induces high mobility group box 1 protein release partly through a TNF-dependent mechanismQ40662552
Inflammation-promoting activity of HMGB1 on human microvascular endothelial cellsQ40686939
Mutagenic Activity of Quercetin and Related CompoundsQ40784827
Quercetin inhibits matrix metalloproteinase-1 expression in human vascular endothelial cells through extracellular signal-regulated kinaseQ42506097
Quercetin, coenzyme Q10, and L-canavanine as protective agents against lipid peroxidation and nitric oxide generation in endotoxin-induced shock in rat brainQ43636491
Anti-tumor necrosis factor antibody therapy fails to prevent lethality after cecal ligation and puncture or endotoxemiaQ44491825
Mechanism of heme oxygenase-1 gene induction by quercetin in rat aortic smooth muscle cellsQ44876098
Reversal of experimental myoglobinuric acute renal failure in rats by quercetin, a bioflavonoidQ45081537
Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsisQ45122630
In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-kappaB pathwayQ45237108
Suppression of HMGB1 release by stearoyl lysophosphatidylcholine:an additional mechanism for its therapeutic effects in experimental sepsisQ45248637
Quercetin decreases oxidative stress, NF-kappaB activation, and iNOS overexpression in liver of streptozotocin-induced diabetic rats.Q46715254
A pilot study to detect high mobility group box 1 and heat shock protein 72 in cerebrospinal fluid of pediatric patients with meningitisQ46843096
Quercetin inhibits LPS-induced delay in spontaneous apoptosis and activation of neutrophilsQ46876646
The IKK/NF-kappaB pathway.Q46912951
Contributions of high mobility group box protein in experimental and clinical acute lung injury.Q47925618
High mobility group box 1 protein binding to lipopolysaccharide facilitates transfer of lipopolysaccharide to CD14 and enhances lipopolysaccharide-mediated TNF-alpha production in human monocytesQ50335841
Immunomodulating Effects of Flavonoids on Acute and Chronic Inflammatory Responses Caused by Tumor Necrosis Factor αQ57375801
Quercetin arrests human leukemic T-cells in late G1 phase of the cell cycleQ67920848
Cytokine appearance in human endotoxemia and primate bacteremiaQ70371866
Activation of gene expression in human neutrophils by high mobility group box 1 proteinQ73087842
Absorption, metabolism and health effects of dietary flavonoids in manQ74069002
HMG-1 as a mediator of acute lung inflammationQ74279708
Quercetin inhibits LPS-induced nitric oxide and tumor necrosis factor-alpha production in murine macrophagesQ78148082
Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: analysis of the structure-activity relationshipQ80170992
Imaging analysis of STAT1 and NF-kappaB translocation in dendritic cells at the single cell levelQ81157292
Establishment of lipopolysaccharide-dependent nuclear factor kappa B activation in a cell-free systemQ95777584
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)651-660
P577publication date2009-03-05
P1433published inAmerican Journal of Respiratory Cell and Molecular BiologyQ4744268
P1476titleQuercetin prevents LPS-induced high-mobility group box 1 release and proinflammatory function
P478volume41

Reverse relations

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