Glycosylated neurotensin analogues exhibit sub-picomolar anticonvulsant potency in a pharmacoresistant model of epilepsy

scientific article

Glycosylated neurotensin analogues exhibit sub-picomolar anticonvulsant potency in a pharmacoresistant model of epilepsy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/CMDC.200800421
P932PMC publication ID4332545
P698PubMed publication ID19173215

P2093author name stringGrzegorz Bulaj
H Steve White
Misty D Smith
Hee-Kyoung Lee
Liuyin Zhang
P2860cites workNeurotensin and neurotensin receptorsQ28138527
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Enhancement of therapeutic protein in vivo activities through glycoengineeringQ34180647
Interaction between neurotensin and dopamine in the brain. Morphofunctional and clinical evidenceQ34245314
Glycosylated neuropeptides: a new vista for neuropsychopharmacology?Q34439678
Neurotensin and pain modulationQ36547980
Bioactive analogs of neurotensin: focus on CNS effectsQ36553978
Hypothermia and intolerance to cold induced by intracisternal administration of the hypothalamic peptide neurotensinQ39109781
Synthesis and biological effects of c(Lys-Lys-Pro-Tyr-Ile-Leu-Lys-Lys-Pro-Tyr-Ile-Leu) (JMV2012), a new analogue of neurotensin that crosses the blood-brain barrierQ39322793
Functional and pharmacological aspects of central neuropeptidergic transmission mediated by neurotensin and neuromedin n.Q41764021
Improved blood-brain barrier penetration and enhanced analgesia of an opioid peptide by glycosylationQ43803817
Synthesis and biological studies of novel neurotensin(8-13) mimeticsQ44203198
Antinociceptive structure-activity studies with enkephalin-based opioid glycopeptidesQ44345606
Evaluation of lactam-bridged neurotensin analogues adjusting psi(Pro10) close to the experimentally derived bioactive conformation of NT(8-13).Q45104947
An assessment of the antinociceptive efficacy of intrathecal and epidural contulakin-G in rats and dogsQ45210748
In vivo behavioral effects of stable, receptor-selective neurotensin[8-13] analogues that cross the blood-brain barrierQ45274136
Synthesis and biological activities of psi (CH2NH) pseudopeptide analogues of the C-terminal hexapeptide of neurotensin.Q46211646
Synthesis and biological activity of the mono- and di-galactosyl-vespulakinin 1 analoguesQ46410956
Neurotensin enhances GABAergic activity in rat hippocampus CA1 region by modulating L-type calcium channelsQ46704914
Peptide backbone modifications on the C-terminal hexapeptide of neurotensinQ46752813
Regional brain concentrations of neurotensin following amygdaloid kindled and cortical suprathreshold stimulation-induced seizures in the ratQ48114049
In vitro binding and CNS effects of novel neurotensin agonists that cross the blood-brain barrierQ48148694
[3H]neurotensin(8-13) binds in human brain to the same sites as does [3H]neurotensin but with higher affinityQ48166694
Kainic acid induced seizures: changes in somatostatin, substance P and neurotensinQ48364227
Structure-antinociceptive activity of neurotensin and some novel analogues in the periaqueductal gray region of the brainstemQ48670799
Vespulakinins: new carbohydrate-containing bradykinin derivativesQ52440345
Improved bioavailability to the brain of glycosylated Met-enkephalin analogsQ56114253
Neurotensin-induced hypothermia: evidence for an interaction with dopaminergic systems and the hypothalamic--pituitary--thyroid axisQ70529274
Design and structure-activity relationships of C-terminal cyclic neurotensin fragment analoguesQ72430534
Neurotensin binding to extraneural and neural receptors: comparison with biological activity and structure--activity relationshipsQ72863333
Preparation and receptor binding affinities of cyclic C-terminal neurotensin (8-13) and (9-13) analoguesQ73022471
Synthesis and human neurotensin receptor binding activities of neurotensin(8-13) analogues containing position 8 alpha-azido-N-alkylated derivatives of ornithine, lysine, and homolysineQ73223503
Chemical synthesis and receptor binding of catfish somatostatin: a disulfide-bridged beta-D-Galp-(1-->3)-alpha-D-GalpNAc O-glycopeptideQ73431351
Effects of a novel neurotensin peptide analog given extracranially on CNS behaviors mediated by apomorphine and haloperidolQ73455068
Highly potent neurotensin analog that causes hypothermia and antinociceptionQ73525799
Synthesis of neurotensin(9-13) analogues exhibiting enhanced human neurotensin receptor binding affinitiesQ73613784
Dermorphin and deltorphin glycosylated analogues: synthesis and antinociceptive activity after systemic administrationQ78162538
P433issue3
P921main subjectglycosylationQ898365
P304page(s)400-405
P577publication date2009-03-01
P1433published inChemMedChemQ2962252
P1476titleGlycosylated neurotensin analogues exhibit sub-picomolar anticonvulsant potency in a pharmacoresistant model of epilepsy
P478volume4

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cites work (P2860)
Q35066670A marine analgesic peptide, Contulakin-G, and neurotensin are distinct agonists for neurotensin receptors: uncovering structural determinants of desensitization properties
Q38028949Analgesic neuropeptide W suppresses seizures in the brain revealed by rational repositioning and peptide engineering
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Q37845684Anticonvulsant neuropeptides as drug leads for neurological diseases
Q52094879Disease-Modifying Effects of Neural Regeneration Peptide 2945 in the GAERS Model of Absence Epilepsy.
Q42211085Familial 5q12.3 Microdeletion: Evidence for a Locus Associated with Epilepsy.
Q42964771Introduction of lipidization-cationization motifs affords systemically bioavailable neuropeptide Y and neurotensin analogs with anticonvulsant activities
Q27315088Knockdown of Carboxypeptidase A6 in Zebrafish Larvae Reduces Response to Seizure-Inducing Drugs and Causes Changes in the Level of mRNAs Encoding Signaling Molecules
Q34413859Neuropeptides as targets for the development of anticonvulsant drugs.
Q24647835Synthesis and applications of polyamine amino acid residues: improving the bioactivity of an analgesic neuropeptide, neurotensin

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