Differential effects of serine proteases on the migration of normal and tumor cells: implications for tumor microenvironment

scientific article

Differential effects of serine proteases on the migration of normal and tumor cells: implications for tumor microenvironment is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1177/1534735408327250
P698PubMed publication ID19116224
P5875ResearchGate publication ID23713428

P2093author name stringJosef F Novak
Mitchell I Chernin
Deborah A Heitzman
Kirsten L Elzer
P2860cites workc-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2Q24294848
Thrombin receptor overexpression in malignant and physiological invasion processesQ24323035
The proteinase activated receptor-2 (PAR-2) mediates mitogenic responses in human vascular endothelial cellsQ24562218
The plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases, not vitronectin. Implications for antiangiogenic strategiesQ24671642
Thrombin induces increased expression and secretion of angiopoietin-2 from human umbilical vein endothelial cellsQ28203283
Mechanism of trypsin-induced contraction in the rat myometrium: the possible involvement of a novel member of protease-activated receptorQ28345766
The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotectionQ28366344
Chymotrypsin B cached in rat liver lysosomes and involved in apoptotic regulation through a mitochondrial pathwayQ28571338
Activation of type IV procollagenases by human tumor-associated trypsin-2Q28619137
Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cellsQ29619848
Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesivenessQ29620446
Proteolysis of the exodomain of recombinant protease-activated receptors: prediction of receptor activation or inactivation by MALDI mass spectrometry.Q30920864
The thrombin receptor, PAR-1, causes transformation by activation of Rho-mediated signaling pathwaysQ30989694
No grip, no growth: the conceptual basis of excessive proteolysis in the treatment of cancerQ34013819
International Union of Pharmacology. XXVIII. Proteinase-activated receptorsQ34130822
Proteolyzed matrix as a template for the regulation of tumor progressionQ34218154
Protease activated receptors: theme and variationsQ34225983
Tumors are unique organs defined by abnormal signaling and contextQ34231927
Tumor invasion as dysregulated cell motilityQ34231938
Protease-activated receptor-2 (PAR2) in the airwaysQ34305483
Plasmin-induced migration requires signaling through protease-activated receptor 1 and integrin alpha(9)beta(1).Q34332597
Mechanisms of desensitization and resensitization of proteinase-activated receptor-2.Q34388721
Endogenous inhibitors of angiogenesis.Q34419511
'Role reversal' for the receptor PAR1 in sepsis-induced vascular damageQ34686193
Multiple pathways of cell invasion are regulated by multiple families of serine proteases.Q34687536
Protease-activated receptors: contribution to physiology and diseaseQ35715253
Aberrant Expression and Activation of the Thrombin Receptor Protease-Activated Receptor-1 Induces Cell Proliferation and Motility in Human Colon Cancer CellsQ35749110
Physiology and pathophysiology of proteinase-activated receptors (PARs): PARs in the respiratory system: cellular signaling and physiological/pathological rolesQ36012122
Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response.Q36028984
Maximal migration of human smooth muscle cells on fibronectin and type IV collagen occurs at an intermediate attachment strengthQ36232820
Persistent signaling by dysregulated thrombin receptor trafficking promotes breast carcinoma cell invasionQ36420521
Matrix metalloproteinases and cellular motility in development and disease.Q36452765
Expression cloning of oncogenes by retroviral transfer of cDNA librariesQ36566564
Role of thrombin receptor in breast cancer invasivenessQ36618228
Thrombin induces tumor growth, metastasis, and angiogenesis: Evidence for a thrombin-regulated dormant tumor phenotypeQ36650343
Protease-activated receptor signalling, endocytic sorting and dysregulation in cancerQ36753998
Contact interactions between epitheliocytes and fibroblasts: formation of heterotypic cadherin-containing adhesion sites is accompanied by local cytoskeletal reorganization.Q37108656
Differential Ca2+ signaling by thrombin and protease-activated receptor-1-activating peptide in human brain microvascular endothelial cellsQ39658447
Protease-activated receptor-2 is essential for factor VIIa and Xa-induced signaling, migration, and invasion of breast cancer cellsQ40333102
PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells.Q40459317
Heparan sulfate/heparin oligosaccharides protect stromal cell-derived factor-1 (SDF-1)/CXCL12 against proteolysis induced by CD26/dipeptidyl peptidase IV.Q40528868
Thrombin enhances adhesion in pancreatic cancer in vitro through the activation of the thrombin receptor PAR 1.Q40786271
Trafficking of proteinase-activated receptor-2 and beta-arrestin-1 tagged with green fluorescent protein. beta-Arrestin-dependent endocytosis of a proteinase receptorQ40947515
Protease-mediated signalling: new paradigms for cell regulation and drug developmentQ41098006
Streptokinase inhibits pulmonary tumor seeding in an animal experimental modelQ41444122
Unproductive cleavage and the inactivation of protease-activated receptor-1 by trypsin in vascular endothelial cellsQ43263565
Tumor cell invasion is promoted by activation of protease activated receptor-1 in cooperation with the alpha vbeta 5 integrinQ43559301
Retrolective cohort study of an additive therapy with an oral enzyme preparation in patients with multiple myelomaQ43740965
Protease-activated receptor-2 activating peptide SLIGRL inhibits bacterial lipopolysaccharide-induced recruitment of polymorphonuclear leukocytes into the airways of miceQ44009214
Distribution of integrin cell adhesion receptors in normal and malignant lung tissueQ44429276
The enzyme levels in blood are not affected by oral administration of a pancreatic enzyme preparation (Creon 10,000) in pancreas-insufficient pigsQ44715484
Influence of a complementary treatment with oral enzymes on patients with colorectal cancers--an epidemiological retrolective cohort studyQ48683440
Increased incidence of neoplasia of the digestive tract in men with persistent activation of the coagulant pathway.Q50754008
Impact of complementary oral enzyme application on the postoperative treatment results of breast cancer patients--results of an epidemiological multicentre retrolective cohort study.Q51963544
An assay for high-sensitivity detection of thrombin activity and determination of proteases activating or inactivating protease-activated receptors.Q53881002
Human Kallikrein 6 Degrades Extracellular Matrix Proteins and May Enhance the Metastatic Potential of Tumour CellsQ57942209
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)282-294
P577publication date2008-12-01
P1433published inIntegrative Cancer TherapiesQ15708568
P1476titleDifferential effects of serine proteases on the migration of normal and tumor cells: implications for tumor microenvironment
P478volume7

Reverse relations

cites work (P2860)
Q35531332Diallyl trisulfide inhibits migration, invasion and angiogenesis of human colon cancer HT-29 cells and umbilical vein endothelial cells, and suppresses murine xenograft tumour growth
Q37766499Expression of proteinase-activated receptor 1-4 (PAR 1-4) in human cancer
Q44959102Identifying differentially expressed genes in cancer patients using a non-parameter Ising model
Q93386603Lymphotoxin-β receptor-NIK signaling induces alternative RELB/NF-κB2 activation to promote metastatic gene expression and cell migration in head and neck cancer
Q36156772Selective depletion of tumour suppressors Deleted in Colorectal Cancer (DCC) and neogenin by environmental and endogenous serine proteases: linking diet and cancer
Q34947713Trypsin potentiates human fibrocyte differentiation

Search more.