A juxtamembrane mutation in the N terminus of the dopamine transporter induces preference for an inward-facing conformation.

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A juxtamembrane mutation in the N terminus of the dopamine transporter induces preference for an inward-facing conformation. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1124/MOL.108.048744
P932PMC publication ID2684905
P698PubMed publication ID19098122
P5875ResearchGate publication ID23679679

P50authorJonathan JavitchQ47570044
Lei ShiQ60659380
Harel WeinsteinQ62642462
Richard NeubigQ67330747
P2093author name stringAurelio Galli
Bipasha Guptaroy
Margaret E Gnegy
Minjia Zhang
Erica Bowton
Francesca Binda
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The conserved glutamate (Glu136) in transmembrane domain 2 of the serotonin transporter is required for the conformational switch in the transport cycle.Q40306798
Aspartate 345 of the dopamine transporter is critical for conformational changes in substrate translocation and cocaine bindingQ40609766
N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter internalization.Q40685824
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Carrier-mediated release, transport rates, and charge transfer induced by amphetamine, tyramine, and dopamine in mammalian cells transfected with the human dopamine transporter.Q41012269
Dopamine transporters are phosphorylated on N-terminal serines in rat striatumQ42521018
Delineation of an endogenous zinc-binding site in the human dopamine transporterQ42649758
The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding siteQ42909481
Quantitative analysis of inward and outward transport rates in cells stably expressing the cloned human serotonin transporter: inconsistencies with the hypothesis of facilitated exchange diffusionQ43578285
Chemical release of dopamine from striatal homogenates: evidence for an exchange diffusion modelQ43901730
Amphetamine-induced dopamine efflux. A voltage-sensitive and intracellular Na+-dependent mechanismQ44295653
Cocaine affinity decreased by mutations of aromatic residue phenylalanine 105 in the transmembrane domain 2 of dopamine transporterQ44329259
Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding.Q44642043
Phosphorylation and regulation of psychostimulant-sensitive neurotransmitter transportersQ44830234
Effect of metabolic inhibitors and ouabain on amphetamine- and potassium-induced release of biogenic amines from isolated brain tissueQ48211855
Protein kinase C inhibitors block amphetamine-mediated dopamine release in rat striatal slices.Q48519912
Defining proximity relationships in the tertiary structure of the dopamine transporter. Identification of a conserved glutamic acid as a third coordinate in the endogenous Zn(2+)-binding site.Q51427234
Multisubtrate mechanism for the inward transport of dopamine by the human dopamine transporter expressed in HEK cells and its inhibition by cocaine.Q51449176
Differential effect of structural modification of human dopamine transporter on the inward and outward transport of dopamineQ73472949
Amphetamine reverses or blocks the operation of the human noradrenaline transporter depending on its concentration: superfusion studies on transfected cellsQ77292449
A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and functionQ80035224
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectdopamineQ170304
P304page(s)514-524
P577publication date2008-12-19
P1433published inMolecular PharmacologyQ1943386
P1476titleA juxtamembrane mutation in the N terminus of the dopamine transporter induces preference for an inward-facing conformation
P478volume75

Reverse relations

cites work (P2860)
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