Vicious cycle between myeloma cell binding to bone marrow stromal cells via VLA-4-VCAM-1 adhesion and macrophage inflammatory protein-1alpha and MIP-1beta production

scientific article

Vicious cycle between myeloma cell binding to bone marrow stromal cells via VLA-4-VCAM-1 adhesion and macrophage inflammatory protein-1alpha and MIP-1beta production is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00774-008-0012-Z
P8608Fatcat IDrelease_bl23tpkgxbbebjrxso76ascdaq
P698PubMed publication ID19057841

P2093author name stringToshio Matsumoto
Masahiro Abe
Shuji Ozaki
Shinsuke Kido
Kenji Hiura
P2860cites workOsteoprotegerin: a novel secreted protein involved in the regulation of bone densityQ24313918
RANK is essential for osteoclast and lymph node developmentQ24598872
RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesisQ28293009
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesisQ28589430
Multiple myeloma disrupts the TRANCE/ osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progressionQ33944735
Novel therapies targeting the myeloma cell and its bone marrow microenvironmentQ34461557
RANK ligand and osteoprotegerin in myeloma bone disease.Q34992857
Targeting the bone marrow microenvironment in hematologic malignanciesQ35800905
Intracellular signalling controlling integrin activation in lymphocytesQ36167584
Antisense inhibition of macrophage inflammatory protein 1-alpha blocks bone destruction in a model of myeloma bone diseaseQ36169814
The role of the bone marrow microenvironment in multiple myelomaQ36246522
Inducible cell adhesion molecule 110 (INCAM-110) is an endothelial receptor for lymphocytes. A CD11/CD18-independent adhesion mechanismQ36350921
A simple method to assess osteoclast-mediated bone resorption using unfractionated bone cellsQ39100887
Anti-alpha4 integrin antibody suppresses the development of multiple myeloma and associated osteoclastic osteolysisQ40557146
Cell-cell contact between marrow stromal cells and myeloma cells via VCAM-1 and alpha(4)beta(1)-integrin enhances production of osteoclast-stimulating activity.Q40858675
Characterization of VLA-4-dependent myeloma cell adhesion to fibronectin and VCAM-1.Q40910768
Establishment and characterization of an immortal macrophage-like cell line inducible to differentiate to osteoclasts.Q41065416
'Role of bone marrow stromal cells in the growth of human multiple myelomaQ41134325
Adhesive interactions between tumour cells and bone marrow stromal elements in human multiple myeloma.Q41152758
Development of an in vivo model of human multiple myeloma bone diseaseQ41228326
Cell adhesion mediated drug resistance (CAM-DR): role of integrins and resistance to apoptosis in human myeloma cell linesQ41328166
A novel membrane antigen selectively expressed on terminally differentiated human B cells.Q41441966
Role of the bone marrow microenvironment in multiple myelomaQ44202437
Bone marrow stromal-derived soluble factors and direct cell contact contribute to de novo drug resistance of myeloma cells by distinct mechanismsQ44452179
Cancer and the microenvironment: myeloma-osteoclast interactions as a modelQ44802876
Osteoclasts enhance myeloma cell growth and survival via cell-cell contact: a vicious cycle between bone destruction and myeloma expansionQ47371978
Ability of myeloma cells to secrete macrophage inflammatory protein (MIP)-1alpha and MIP-1beta correlates with lytic bone lesions in patients with multiple myelomaQ47965350
T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-lβQ59068529
Macrophage inflammatory protein 1-alpha is a potential osteoclast stimulatory factor in multiple myelomaQ73971509
Constitutive chemokine production results in activation of leukocyte function-associated antigen-1 on adult T-cell leukemia cellsQ74511360
Role for macrophage inflammatory protein (MIP)-1alpha and MIP-1beta in the development of osteolytic lesions in multiple myelomaQ74676116
Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environmentQ77337113
Constitutive up-regulation of integrin-mediated adhesion of tumor-infiltrating lymphocytes to osteoblasts and bone marrow-derived stromal cellsQ77343472
Clinical significance of chemokine receptor (CCR1, CCR2 and CXCR4) expression in human myeloma cells: the association with disease activity and survivalQ82481954
BAFF and APRIL as osteoclast-derived survival factors for myeloma cells: a rationale for TACI-Fc treatment in patients with multiple myelomaQ83159481
P433issue1
P921main subjectinflammationQ101991
macrophageQ184204
P304page(s)16-23
P577publication date2008-12-05
P1433published inJournal of Bone and Mineral MetabolismQ15767236
P1476titleVicious cycle between myeloma cell binding to bone marrow stromal cells via VLA-4-VCAM-1 adhesion and macrophage inflammatory protein-1alpha and MIP-1beta production
P478volume27

Reverse relations

cites work (P2860)
Q35612803Acquisition of resistance toward HYD1 correlates with a reduction in cleaved α4 integrin expression and a compromised CAM-DR phenotype
Q24701763Bindarit, an inhibitor of monocyte chemotactic protein synthesis, protects against bone loss induced by chikungunya virus infection
Q89878681Bone Marrow Stromal Cells Drive Key Hallmarks of B Cell Malignancies
Q38843253Bone metastasis: the importance of the neighbourhood.
Q55395268Bone-targeted agents in multiple myeloma.
Q36206430Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma
Q37879210CCR1 as a target for multiple myeloma
Q57284923Chemokine analysis as a novel diagnostic modality in the early prediction of the outcome of non-union therapy: a matched pair analysis
Q28477867Computational modeling of interactions between multiple myeloma and the bone microenvironment
Q37499263Heparanase-induced shedding of syndecan-1/CD138 in myeloma and endothelial cells activates VEGFR2 and an invasive phenotype: prevention by novel synstatins
Q39524246Hypoxia-inducible factor 1 alpha-activated angiopoietin-like protein 4 contributes to tumor metastasis via vascular cell adhesion molecule-1/integrin β1 signaling in human hepatocellular carcinoma
Q57904674Increased expression of macrophage inflammatory protein-1α on trephine biopsies correlates with extensive bone disease, increased angiogenesis and advanced stage in newly diagnosed patients with multiple myeloma
Q39758292Inhibition of Transforming Growth Factor-β Activation Diminishes Tumor Progression and Osteolytic Bone Disease in Mouse Models of Multiple Myeloma
Q37734280Mechanism of action of immunomodulatory agents in multiple myeloma
Q36673755Novel Bruton's tyrosine kinase inhibitors currently in development
Q37822742Novel agents to improve outcome of allogeneic transplantation for patients with multiple myeloma.
Q53238656Targeting myeloma-osteoclast interaction with Vγ9Vδ2 T cells.
Q37946702Targeting the interplay between myeloma cells and the bone marrow microenvironment in myeloma
Q28473419Tgf-Beta inhibition restores terminal osteoblast differentiation to suppress myeloma growth
Q39472801The selective adhesion molecule inhibitor Natalizumab decreases multiple myeloma cell growth in the bone marrow microenvironment: therapeutic implications
Q50064432Tooth Extraction Locally Stimulates Proliferation of Multiple Myeloma in a Patient with Mandibular Localizations
Q27316139Very late antigen-4 (α(4)β(1) Integrin) targeted PET imaging of multiple myeloma

Search more.