Induction of histone deacetylases (HDACs) in human abdominal aortic aneurysm: therapeutic potential of HDAC inhibitors

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Induction of histone deacetylases (HDACs) in human abdominal aortic aneurysm: therapeutic potential of HDAC inhibitors is …
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scholarly articleQ13442814

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P356DOI10.1242/DMM.024513
P932PMC publication ID4892665
P698PubMed publication ID26989193
P5875ResearchGate publication ID298795277

P50authorMaría GalánQ57352557
Mercedes CamachoQ41875511
José Martínez-GonzálezQ47504227
P2093author name stringCristina Rodriguez
José Antonio Rodríguez
Mar Orriols
Saray Varona
Silvia Aguiló
Jaume Dilmé
P2860cites workNR4A receptors up-regulate the antiproteinase alpha-2 macroglobulin (A2M) and modulate MMP-2 and MMP-9 in vascular smooth muscle cellsQ61864764
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Inflammation and matrix metalloproteinases in the enlarging abdominal aortic aneurysmQ71938798
Aortic dissection precedes formation of aneurysms and atherosclerosis in angiotensin II-infused, apolipoprotein E-deficient miceQ73652351
Matrix metalloproteinase-2 production and its binding to the matrix are increased in abdominal aortic aneurysmsQ77380951
A novel histone deacetylase inhibitor reduces abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient miceQ81488583
Doxycycline inhibition of abdominal aortic aneurysm growth: a systematic review of the literatureQ84147910
Improved synthesis and structural reassignment of MC1568: a class IIa selective HDAC inhibitorQ87142814
Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexesQ39842424
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Risk factors for abdominal aortic aneurysms: a 7-year prospective study: the Tromsø Study, 1994-2001.Q46052019
Evaluation of the in vitro and in vivo antitumor activity of histone deacetylase inhibitors for the therapy of retinoblastomaQ46167944
Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin II infusion and aortic bandingQ46870302
Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysmsQ24623052
Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activityQ28508698
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Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancerQ29615649
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Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophyQ33929939
The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokinesQ34015778
Histone deacetylase inhibitor up-regulates RECK to inhibit MMP-2 activation and cancer cell invasion.Q34206478
Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient miceQ34433103
Epigenetic control of vascular smooth muscle cells in Marfan and non-Marfan thoracic aortic aneurysms.Q34485800
Abdominal aortic aneurysm: pathogenesis and implications for managementQ34566262
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Prolonged infusion of angiotensin II in apoE(-/-) mice promotes macrophage recruitment with continued expansion of abdominal aortic aneurysmQ35167994
Detection, management, and prospects for the medical treatment of small abdominal aortic aneurysmsQ35578689
Accelerated aneurysmal dilation associated with apoptosis and inflammation in a newly developed calcium phosphate rodent abdominal aortic aneurysm modelQ36129293
Inflammation and cellular immune responses in abdominal aortic aneurysmsQ36404719
Histone deacetylases--an important class of cellular regulators with a variety of functionsQ36766483
Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemiaQ37095364
ANG II infusion promotes abdominal aortic aneurysms independent of increased blood pressure in hypercholesterolemic miceQ37200287
Microvascular COX-2/mPGES-1/EP-4 axis in human abdominal aortic aneurysm.Q37305427
Epigenetic histone acetylation modifiers in vascular remodelling: new targets for therapy in cardiovascular disease.Q37369595
Histone deacetylase inhibitors: keeping momentum for neuromuscular and cardiovascular diseases treatmentQ37708759
Pathophysiology and epidemiology of abdominal aortic aneurysmsQ37809741
Can pharmacologic agents slow abdominal aortic aneurysm growth?Q38010892
Involvement of the renin-angiotensin system in abdominal and thoracic aortic aneurysms.Q38025669
Immunomodulatory effects of histone deacetylase inhibitorsQ38051693
Class I histone deacetylase inhibition modulates metalloproteinase expression and blocks cytokine-induced cartilage degradation.Q39168362
Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysmsQ39738340
The novel histone deacetylase inhibitors metacept-1 and metacept-3 potently increase HIV-1 transcription in latently infected cells.Q39824443
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P433issue5
P921main subjectabdominal aortic aneurysmQ2256736
P304page(s)541-552
P577publication date2016-03-17
P1433published inDisease Models & MechanismsQ1524006
P1476titleInduction of histone deacetylases (HDACs) in human abdominal aortic aneurysm: therapeutic potential of HDAC inhibitors
P478volume9

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Q55455553Aging-Induced Biological Changes and Cardiovascular Diseases.
Q90170910Angiotensin II represses Npr1 expression and receptor function by recruitment of transcription factors CREB and HSF-4a and activation of HDACs
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Q51762349Epigenetic modulation of vascular diseases: Assessing the evidence and exploring the opportunities.
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Q92848013Epigenetics and vascular diseases
Q39100045Genetic and Epigenetic Regulation of Aortic Aneurysms
Q90355401Histone Acetyltransferase-Dependent Pathways Mediate Upregulation of NADPH Oxidase 5 in Human Macrophages under Inflammatory Conditions: A Potential Mechanism of Reactive Oxygen Species Overproduction in Atherosclerosis
Q98291727Histone Deacetylase Inhibition Attenuates Aortic Remodeling in Rats under Pressure Overload
Q37274168NOR-1/NR4A3 regulates the cellular inhibitor of apoptosis 2 (cIAP2) in vascular cells: role in the survival response to hypoxic stress
Q50204446The epigenetic promise to improve prognosis of heart failure and heart transplantation

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