Na-butyrate increases the production and alpha2,6-sialylation of recombinant interferon-gamma expressed by alpha2,6- sialyltransferase engineered CHO cells

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Na-butyrate increases the production and alpha2,6-sialylation of recombinant interferon-gamma expressed by alpha2,6- sialyltransferase engineered CHO cells is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1027671102
P356DOI10.1023/A:1008080432681
P932PMC publication ID3449462
P698PubMed publication ID19003337

P2093author name stringL Monaco
N Jenkins
M Soria
J M Engasser
D Lamotte
A Marc
L Buckberry
P2860cites workN-glycosylation of recombinant human interferon-gamma produced in different animal expression systemsQ30430759
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Construction of stable BHK-21 cells coexpressing human secretory glycoproteins and human Gal(beta 1-4)GlcNAc-R alpha 2,6-sialyltransferase alpha 2,6-linked NeuAc is preferentially attached to the Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-3)-branch ofQ41295222
Removal of sialic acid from a glycoprotein in CHO cell culture supernatant by action of an extracellular CHO cell sialidaseQ41327511
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Modifications of cell surface sialic acids modulate cell adhesion mediated by sialoadhesin and CD22.Q41424634
Role of N-glycosylation in the synthesis, dimerization and secretion of human interferon-gamma.Q41430099
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n-Butyrate alters chromatin accessibility to DNA repair enzymesQ41473570
Butyrate induced apoptosis in lymphoid cells preceded by transient over-expression of HSP70 mRNA.Q41494758
Role of environmental conditions on the expression levels, glycoform pattern and levels of sialyltransferase for hFSH produced by recombinant CHO cellsQ41505031
Effect of lipid supplements on the production and glycosylation of recombinant interferon-gamma expressed in CHO cellsQ41505038
Expression systems: a user's guide. Emphasis has shifted from the vector construct to the host organismQ41539906
Induction of recombinant human gamma-glutamyl transferase by sodium butyrate in transfected V79 and CHO Chinese hamster cells.Q41552797
Effect of dexamethasone, dimethylsulfoxide and sodium butyrate on a human hepatoma cell line PLC/PRF/5Q41597597
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The use of lactate dehydrogenase (LDH) release kinetics for the evaluation of death and growth of mammalian cells in perfusion reactorsQ41640259
Production of analytical quantities of recombinant proteins in Chinese hamster ovary cells using sodium butyrate to elevate gene expressionQ41683342
Increased synthesis of secreted proteins induces expression of glucose-regulated proteins in butyrate-treated Chinese hamster ovary cellsQ41758613
Stimulation of tissue-type plasminogen activator gene expression by sodium butyrate and trichostatin A in human endothelial cells involves histone acetylationQ41808615
N-glycosylation of human interferon-gamma: glycans at Asn-25 are critical for protease resistance.Q41987345
Effect of carbohydrates on the pharmacokinetics of human interferon-gammaQ42069767
Effects of butyrate on cell cycle progression and polyploidization of various types of mammalian cellsQ43907523
Antigenic characteristics of glycosylated natural and unglycosylated recombinant human gamma-interferonQ44102668
Alteration of terminal glycosylation sequences on N-linked oligosaccharides of Chinese hamster ovary cells by expression of beta-galactoside alpha 2,6-sialyltransferase.Q46007488
Substantial overproduction of antibodies by applying osmotic pressure and sodium butyrateQ47867095
Expression of human immune interferon cDNA in E. coli and monkey cellsQ48405865
Determination of sialic acids.Q54524671
Chinese hamster ovary cell growth and interferon production kinetics in stirred batch cultureQ67528226
n-butyrate reduces the expression of beta-galactoside alpha 2,6-sialyltransferase in Hep G2 cellsQ67848553
Natural human interferon-gamma. Complete amino acid sequence and determination of sites of glycosylationQ70480282
n-Butyrate induces plasminogen activator inhibitor type 1 messenger RNA in cultured Hep G2 cellsQ71150612
Expression and regulation of glycosyltransferases for N-glycosyl oligosaccharides in fresh human surgical and murine tissues and cultured cell linesQ71572359
Histone hyperacetylation plays a role in augmentation of IL-4-induced IgE production in LPS-stimulated murine B-lymphocytes by sodium butyrateQ71580939
Production of a membrane-bound protein, the human gamma-glutamyl transferase, by CHO cells cultivated on microcarriers, in aggregates and in suspensionQ71672502
Sialidase activity in culture fluid of Chinese hamster ovary cells during batch culture and its effects on recombinant human antithrombin III integrityQ71954372
Site- and branch-specific sialylation of recombinant human interferon-gamma in Chinese hamster ovary cell cultureQ81660497
P433issue1
P304page(s)55-64
P577publication date1999-01-01
P1433published inCytotechnologyQ15752151
P1476titleNa-butyrate increases the production and alpha2,6-sialylation of recombinant interferon-gamma expressed by alpha2,6- sialyltransferase engineered CHO cells
P478volume29