Novel MET/TIE2/VEGFR2 inhibitor altiratinib inhibits tumor growth and invasiveness in bevacizumab-resistant glioblastoma mouse models

scientific article published on 9 March 2016

Novel MET/TIE2/VEGFR2 inhibitor altiratinib inhibits tumor growth and invasiveness in bevacizumab-resistant glioblastoma mouse models is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NEUONC/NOW030
P932PMC publication ID4998992
P698PubMed publication ID26965451

P2093author name stringBryan D Smith
Daniel L Flynn
Ningyi Tiao
Verlene Henry
John F de Groot
Soon Young Park
Yuji Piao
P2860cites workScatter factor/hepatocyte growth factor protects against cytotoxic death in human glioblastoma via phosphatidylinositol 3-kinase- and AKT-dependent pathways.Q55475281
Genetic and Expression Analysis of MET, MACC1, and HGF in Metastatic Colorectal Cancer: Response to Met Inhibition in Patient Xenografts and Pathologic CorrelationsQ56688160
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VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complexQ24293027
Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752Q24541450
Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasisQ24608039
Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistanceQ24645668
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1Q24651548
Comprehensive genomic characterization defines human glioblastoma genes and core pathwaysQ24656128
Altiratinib Inhibits Tumor Growth, Invasion, Angiogenesis, and Microenvironment-Mediated Drug Resistance via Balanced Inhibition of MET, TIE2, and VEGFR2Q27701843
A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivoQ28183526
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogeneQ28202069
Invasive growth: a MET-driven genetic programme for cancer and stem cellsQ28253680
Stromal fibroblasts in cancer initiation and progressionQ29618873
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesisQ29619677
Hepatocyte Growth Factor Sensitizes Brain Tumors to c-MET Kinase InhibitionQ30414265
Bevacizumab for recurrent malignant gliomas: efficacy, toxicity, and patterns of recurrenceQ31148416
Anti-vascular endothelial growth factor therapy-induced glioma invasion is associated with accumulation of Tie2-expressing monocytesQ33688579
Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growthQ33732486
Glioblastoma recurrence after cediranib therapy in patients: lack of "rebound" revascularization as mode of escapeQ34783533
Hepatocyte growth factor (HGF) autocrine activation predicts sensitivity to MET inhibition in glioblastomaQ35673676
Hepatocyte growth factor enhances vascular endothelial growth factor-induced angiogenesis in vitro and in vivoQ35746501
Suppression of Tumor Invasion and Metastasis by Concurrent Inhibition of c-Met and VEGF Signaling in Pancreatic Neuroendocrine TumorsQ35967197
Met and hepatocyte growth factor/scatter factor expression in human gliomasQ36894692
High-throughput flow cytometry screening reveals a role for junctional adhesion molecule a as a cancer stem cell maintenance factorQ37507256
Bevacizumab for the treatment of high-grade glioma: an update after phase III trials.Q38198121
Glioma in 2014: unravelling tumour heterogeneity-implications for therapyQ38308027
Acquired Resistance to Anti-VEGF Therapy in Glioblastoma Is Associated with a Mesenchymal TransitionQ39134430
Glioblastoma resistance to anti-VEGF therapy is associated with myeloid cell infiltration, stem cell accumulation, and a mesenchymal phenotypeQ39281709
Targeting the c-Met pathway potentiates glioblastoma responses to gamma-radiationQ40408804
Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer.Q40453775
Transcriptional mimicry by tumor-associated stromaQ41152059
Tumor measurement in the nude mouseQ41355093
Prospective, high-throughput molecular profiling of human gliomasQ41970534
The immunohistochemical expression of c-Met is an independent predictor of survival in patients with glioblastoma multiformeQ43819146
Glycomic and transcriptomic response of GSC11 glioblastoma stem cells to STAT3 phosphorylation inhibition and serum-induced differentiationQ44065642
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomasQ45345804
MET gain in diffuse astrocytomas is associated with poorer outcomeQ45839064
Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer.Q45866300
Prognostic significance of c-Met expression in glioblastomasQ46170165
MET Signaling Regulates Glioblastoma Stem CellsQ48498498
Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors.Q50754378
Role of angiopoietin-2 in adaptive tumor resistance to VEGF signaling blockade.Q55072288
The MET oncogene is a functional marker of a glioblastoma stem cell subtype.Q55462084
P433issue9
P921main subjectglioblastomaQ282142
bevacizumabQ413299
neoplastic invasivenessQ112498967
P304page(s)1230-1241
P577publication date2016-03-09
P1433published inNeuro-OncologyQ15724471
P1476titleNovel MET/TIE2/VEGFR2 inhibitor altiratinib inhibits tumor growth and invasiveness in bevacizumab-resistant glioblastoma mouse models
P478volume18

Reverse relations

cites work (P2860)
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