The role of the polycomb complex in silencing alpha-globin gene expression in nonerythroid cells

scientific article

The role of the polycomb complex in silencing alpha-globin gene expression in nonerythroid cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2008-06-161901
P932PMC publication ID2572806
P698PubMed publication ID18689541
P5875ResearchGate publication ID23158300

P50authorDouglas HiggsQ5301594
Ian DunhamQ30093275
Michelle L HollandQ41813373
Marco De GobbiQ53026545
Karen M LowerQ55690369
P2093author name stringJackie Sloane-Stanley
Christoph Koch
David Garrick
Nicki Gray
Helena Ayyub
Michelle Rugless
Vasiliki Samara
P2860cites workTranslating the Histone CodeQ22065840
The Polycomb group protein EZH2 directly controls DNA methylationQ24299020
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activityQ24305075
Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27Q24672052
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste proteinQ24682617
Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylationQ28139187
Control of developmental regulators by Polycomb in human embryonic stem cellsQ28235841
A regulatory SNP causes a human genetic disease by creating a new transcriptional promoterQ28242432
The relationship between chromosome structure and function at a human telomeric regionQ28304976
The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen speciesQ28349324
The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiationQ28508225
Histone methyltransferases direct different degrees of methylation to define distinct chromatin domainsQ28609779
Polycomb complexes repress developmental regulators in murine embryonic stem cellsQ29547274
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitionsQ29614512
Partitioning and plasticity of repressive histone methylation states in mammalian chromatinQ29614513
Polycomb silencers control cell fate, development and cancerQ29619697
Annotation of cis-regulatory elements by identification, subclassification, and functional assessment of multispecies conserved sequencesQ33895983
Identification of a conserved erythroid specific domain of histone acetylation across the alpha-globin gene clusterQ33947031
DNA methylation in the human γδβ-globin locus in erythroid and nonerythroid tissuesQ34251617
EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancerQ34268216
Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancerQ34409667
The genomic landscape of histone modifications in human T cellsQ35094537
Hyperconserved CpG domains underlie Polycomb-binding sitesQ35720547
Chromatin structure and developmental expression of the human alpha-globin clusterQ36912032
A conserved truncated isoform of the ATR-X syndrome protein lacking the SWI/SNF-homology domainQ40598478
The pattern of replication at a human telomeric region (16p13.3): its relationship to chromosome structure and gene expressionQ40942805
Understanding alpha globin gene expression: a step towards effective gene therapy.Q41752951
Tissue-specific TAFs counteract Polycomb to turn on terminal differentiation.Q47070063
How transcriptional and epigenetic programmes are played out on an individual mammalian gene cluster during lineage commitment and differentiation.Q50940401
Expression of alpha- and beta-globin genes occurs within different nuclear domains in haemopoietic cells.Q52134560
Tissue-specific histone modification and transcription factor binding in alpha globin gene expression.Q53026451
alpha-thalassemia resulting from a negative chromosomal position effectQ57415425
Clinical significance of enhancer of zeste homolog 2 expression in colorectal cancer casesQ81661343
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectgene silencingQ1431332
P304page(s)3889-3899
P577publication date2008-08-08
P1433published inBloodQ885070
P1476titleThe role of the polycomb complex in silencing alpha-globin gene expression in nonerythroid cells
P478volume112

Reverse relations

cites work (P2860)
Q24622599A long ncRNA links copy number variation to a polycomb/trithorax epigenetic switch in FSHD muscular dystrophy
Q28593101An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment
Q37594579Chromosome crosstalk in three dimensions.
Q41270039DNA methylation of intragenic CpG islands depends on their transcriptional activity during differentiation and disease.
Q33662656Differential regulation of the α-globin locus by Krüppel-like Factor 3 in erythroid and non-erythroid cells
Q38185270Disruption of long-range gene regulation in human genetic disease: a kaleidoscope of general principles, diverse mechanisms and unique phenotypic consequences
Q38340158Enhancer of Zeste 2 (EZH2) is up-regulated in malignant gliomas and in glioma stem-like cells.
Q30885935Epigenetic signatures associated with different levels of differentiation potential in human stem cells
Q34027198Generation of bivalent chromatin domains during cell fate decisions
Q42076431H3K27me3 forms BLOCs over silent genes and intergenic regions and specifies a histone banding pattern on a mouse autosomal chromosome
Q27318586High resolution imaging reveals heterogeneity in chromatin states between cells that is not inherited through cell division
Q34582928Histone code pathway involving H3 S28 phosphorylation and K27 acetylation activates transcription and antagonizes polycomb silencing
Q34770424Molecular mechanism of yisui shengxue granule, a complex chinese medicine, on thalassemia patients suffering from hemolysis and anemia of erythrocytes
Q34230375PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells
Q39029997PRC2-independent chromatin compaction and transcriptional repression in cancer
Q33740016Plant metabolic clusters - from genetics to genomics
Q35237389Polycomb eviction as a new distant enhancer function.
Q90029300Potential new approaches to the management of the Hb Bart's hydrops fetalis syndrome: the most severe form of α-thalassemia
Q39703639Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination
Q42361973Selective silencing of α-globin by the histone demethylase inhibitor IOX1: a potentially new pathway for treatment of β-thalassemia
Q33920071Sensing core histone phosphorylation - a matter of perfect timing.
Q38026940The STEAP protein family: versatile oxidoreductases and targets for cancer immunotherapy with overlapping and distinct cellular functions.
Q41937379The molecular basis of α-thalassemia
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Q35351225Uncovering enhancer functions using the α-globin locus
Q38676718Understanding α-globin gene regulation and implications for the treatment of β-thalassemia
Q35836891α-Globin as a molecular target in the treatment of β-thalassemia

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