S-adenosylhomocysteine inhibits NF-κB-mediated gene expression in hepatocytes and confers sensitivity to TNF cytotoxicity

scientific article

S-adenosylhomocysteine inhibits NF-κB-mediated gene expression in hepatocytes and confers sensitivity to TNF cytotoxicity is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/ACER.12315
P932PMC publication ID4035050
P698PubMed publication ID24224954

P2093author name stringCraig J McClain
Mark A Doll
Walter H Watson
Tom J Burke
P2860cites workS-adenosylhomocysteine sensitizes to TNF-alpha hepatotoxicity in mice and liver cells: a possible etiological factor in alcoholic liver diseaseQ40512960
TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytesQ40797297
3-deazaadenosine, a S-adenosylhomocysteine hydrolase inhibitor, has dual effects on NF-kappaB regulation. Inhibition of NF-kappaB transcriptional activity and promotion of IkappaBalpha degradationQ40945823
NF-kappaB inactivation converts a hepatocyte cell line TNF-alpha response from proliferation to apoptosis.Q41005955
In vitro tumor necrosis factor cytotoxicity in Hep G2 liver cellsQ41357228
Adenosine and homocysteine together enhance TNF-mediated cytotoxicity but do not alter activation of nuclear factor-kappa B in L929 cells.Q41448514
Enhanced PDE4B expression augments LPS-inducible TNF expression in ethanol-primed monocytes: relevance to alcoholic liver diseaseQ42148248
Negative regulation of the rat glutathione S-transferase A2 gene by glucocorticoids involves a canonical glucocorticoid consensus sequence.Q42456188
Ethanol exposure modulates hepatic S-adenosylmethionine and S-adenosylhomocysteine levels in the isolated perfused rat liver through changes in the redox state of the NADH/NAD(+) systemQ42607981
Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in ratsQ44580088
Mitochondrial S-adenosyl-L-methionine transport is insensitive to alcohol-mediated changes in membrane dynamics.Q46039135
Implication of cytokines: Roles of tumor necrosis factor-alpha in liver injuryQ46173742
Mechanism of mitochondrial glutathione-dependent hepatocellular susceptibility to TNF despite NF-kappaB activation.Q46699956
Ethanol feeding of micropigs alters methionine metabolism and increases hepatocellular apoptosis and proliferationQ46986722
S-adenosylmethionine deficiency and TNF-alpha in lipopolysaccharide-induced hepatic injuryQ47876194
Modulation of tumor necrosis factor-alpha-mediated cytotoxicity by changes of the cellular methylation state: mechanism and in vivo relevance.Q52535032
Targeting A20 enhances TRAIL-induced apoptosis in hepatocellular carcinoma cells.Q53189392
S-adenosyl-L-methionine attenuates alcohol-induced liver injury in the baboonQ68716606
Antioxidants attenuate nuclear factor-kappa B activation and tumor necrosis factor-alpha production in alcoholic hepatitis patient monocytes and rat Kupffer cells, in vitroQ73310303
Gadolinium chloride blocks alcohol-dependent liver toxicity in rats treated chronically with intragastric alcohol despite the induction of CYP2E1Q73424895
Antibodies to tumor necrosis factor alfa attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the ratQ73939862
NF-{kappa}B is transported into the nucleus by importin {alpha}3 and importin {alpha}4Q24293000
NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathwayQ24321670
Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient miceQ24616207
TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaBQ29614706
An essential role for NF-kappaB in preventing TNF-alpha-induced cell deathQ29614707
Molecular mechanisms of necroptosis: an ordered cellular explosionQ29616004
Suppression of TNF-alpha-induced apoptosis by NF-kappaBQ29618717
Transcriptional activation of the tumor necrosis factor alpha-inducible zinc finger protein, A20, is mediated by kappa B elementsQ30990490
A20 protects mice from D-galactosamine/lipopolysaccharide acute toxic lethal hepatitisQ33183441
A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activationQ33204720
Diclofenac inhibits tumor necrosis factor-α-induced nuclear factor-κB activation causing synergistic hepatocyte apoptosisQ33854289
Galactosamine-induced sensitization to the lethal effects of endotoxinQ33983065
The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity.Q34561178
S-Adenosylmethionine, cytokines, and alcoholic liver diseaseQ34774401
S-adenosylmethionine decreases lipopolysaccharide-induced phosphodiesterase 4B2 and attenuates tumor necrosis factor expression via cAMP/protein kinase A pathwayQ34868229
A histone methylation-dependent DNA methylation pathway is uniquely impaired by deficiency in Arabidopsis S-adenosylhomocysteine hydrolaseQ35175920
A20 ubiquitin ligase-mediated polyubiquitination of RIP1 inhibits caspase-8 cleavage and TRAIL-induced apoptosis in glioblastomaQ35967192
Alcohol-induced S-adenosylhomocysteine accumulation in the liver sensitizes to TNF hepatotoxicity: possible involvement of mitochondrial S-adenosylmethionine transportQ36016487
Beyond IkappaBs: alternative regulation of NF-kappaB activityQ36790420
Methionine metabolism and liver diseaseQ37106480
Regulation of NF-κB signaling by the A20 deubiquitinaseQ37985541
Transactivation of gene expression by NF-κB is dependent on thioredoxin reductase activityQ39502076
P4510describes a project that usesImageJQ1659584
P433issue4
P921main subjectTNFQ18032037
cytotoxicityQ246181
NF-κBQ411114
P1104number of pages8
P304page(s)889-896
P577publication date2013-11-13
P1433published inAlcoholism: Clinical and Experimental ResearchQ4713331
P1476titleS-adenosylhomocysteine inhibits NF-κB-mediated gene expression in hepatocytes and confers sensitivity to TNF cytotoxicity
P478volume38

Reverse relations

cites work (P2860)
Q47793319Activation of Nuclear Factor-κB by Tumor Necrosis Factor in Intestinal Epithelial Cells and Mouse Intestinal Epithelia Reduces Expression of the Chloride Transporter SLC26A3.
Q60919515Inhibition of Necroptosis Rescues SAH-Induced Synaptic Impairments in Hippocampus via CREB-BDNF Pathway
Q104064325Methionine metabolism in chronic liver diseases: an update on molecular mechanism and therapeutic implication
Q87739240Prednisolone plus S-adenosil-L-methionine in severe alcoholic hepatitis

Search more.