Silencing of Bcl-2 expression by small interfering RNA induces autophagic cell death in MCF-7 breast cancer cells

scientific article

Silencing of Bcl-2 expression by small interfering RNA induces autophagic cell death in MCF-7 breast cancer cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4161/AUTO.6083
P8608Fatcat IDrelease_pthtccpepbaxliqfo2awfybw7i
P698PubMed publication ID18424910
P5875ResearchGate publication ID5427700

P2093author name stringGabriel Lopez-Berestein
Seiji Kondo
Bulent Ozpolat
Ugur Akar
Banu Arun
Yasuko Kondo
Angela Sanguino
Magaly Barria
Ana Tari
Arturo Chaves-Reyez
P433issue5
P921main subjectbreast cancerQ128581
autophagyQ288322
cell deathQ2383867
P304page(s)669-679
P577publication date2008-04-10
P1433published inAutophagyQ1255295
P1476titleSilencing of Bcl-2 expression by small interfering RNA induces autophagic cell death in MCF-7 breast cancer cells
P478volume4

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cites work (P2860)
Q427985125-Azacytidine specifically inhibits the NIH-3T3 PCD process induced by TNF-alpha and cycloheximide via affecting BCL-XL.
Q39071997Acetazolamide triggers death inducing autophagy in T-47D breast cancer cells.
Q58801878Activating Autophagy Enhanced the Antitumor Effect of Antibody Drug Conjugates Rituximab-Monomethyl Auristatin E
Q37145468Activation of Autophagy Pathway Suppresses the Expression of iNOS, IL6 and Cell Death of LPS-Stimulated Microglia Cells
Q39210293Alternative Pathways of Cancer Cell Death by Rottlerin: Apoptosis versus Autophagy.
Q35798939Andrographolide Analogue Induces Apoptosis and Autophagy Mediated Cell Death in U937 Cells by Inhibition of PI3K/Akt/mTOR Pathway
Q30579272Antagonism of tumoral prolactin receptor promotes autophagy-related cell death
Q44441021Anti-cell death engineering of CHO cells: co-overexpression of Bcl-2 for apoptosis inhibition, Beclin-1 for autophagy induction
Q38388106Antiapoptotic Bcl-2 protein as a potential target for cancer therapy: A mini review
Q39421552Antitumor effects of cytoplasmic delivery of an innate adjuvant receptor ligand, poly(I:C), on human breast cancer
Q41167283Apatinib promotes autophagy and apoptosis through VEGFR2/STAT3/BCL-2 signaling in osteosarcoma
Q38660093Apogossypolone induces apoptosis and autophagy in nasopharyngeal carcinoma cells in an in vitro and in vivo study
Q39328827Apogossypolone induces autophagy and apoptosis in breast cancer MCF-7 cells in vitro and in vivo
Q38819542Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy: An analytical technique to understand therapeutic responses at the molecular level.
Q29614564Autophagic cell death: the story of a misnomer
Q38979982Autophagic regulation of cell growth by altered expression of Beclin 1 in triple-negative breast cancer.
Q82997243Autophagy and cancer therapy
Q38104448Autophagy and cancer: taking the 'toxic' out of cytotoxics
Q27023375Autophagy and endocrine resistance in breast cancer
Q37662807Autophagy and tumorigenesis
Q35591562Autophagy as a therapeutic target in cancer.
Q35639764Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage
Q36767664Autophagy inhibition enhances apigenin-induced apoptosis in human breast cancer cells
Q36398762Autophagy regulation in the development and treatment of breast cancer
Q38066407Autophagy, apoptosis, mitoptosis and necrosis: interdependence between those pathways and effects on cancer
Q35146596Autophagy: cancer's friend or foe?
Q37930982Autophagy: for better or for worse
Q46060884Bcl-2 complexed with Beclin-1 maintains full anti-apoptotic function.
Q36169503Bcl-2 confers survival in cisplatin treated cervical cancer cells: circumventing cisplatin dose-dependent toxicity and resistance
Q38973420Bcl-2 down-regulation by small interfering RNA induces Beclin1-dependent autophagy in human SGC-7901 cells
Q38000992Bcl-2:Beclin 1 complex: multiple, mechanisms regulating autophagy/apoptosis toggle switch.
Q37272761Bozepinib, a novel small antitumor agent, induces PKR-mediated apoptosis and synergizes with IFNα triggering apoptosis, autophagy and senescence
Q33730108C10ORF10/DEPP-mediated ROS accumulation is a critical modulator of FOXO3-induced autophagy
Q33888775CD24 Expression and differential resistance to chemotherapy in triple-negative breast cancer.
Q37178387CSC-3436 switched tamoxifen-induced autophagy to apoptosis through the inhibition of AMPK/mTOR pathway
Q33674213Cellular stress responses: cell survival and cell death
Q39531127Characterization and comparison of telomere length, telomerase and reverse transcriptase activity and gene expression in human mesenchymal stem cells and cancer cells of various origins
Q30513775Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy
Q38689955Clinical relevance of autophagic therapy in cancer: Investigating the current trends, challenges, and future prospects
Q37338907Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers
Q37275481Control of autophagy by oncogenes and tumor suppressor genes
Q33907663Cytotoxic autophagy in cancer therapy
Q54454072Decreased expression of Beclin 1 in eutopic endometrium of women with adenomyosis.
Q36107033Delivery of chemo-sensitizing siRNAs to HER2+-breast cancer cells using RNA aptamers
Q48101315Development of Dual-Pore Coexisting Branched Silica Nanoparticles for Efficient Gene-Chemo Cancer Therapy
Q34109699Down-regulation of 5-HT1B and 5-HT1D receptors inhibits proliferation, clonogenicity and invasion of human pancreatic cancer cells
Q34474347Downregulation of autophagy by Bcl-2 promotes MCF7 breast cancer cell growth independent of its inhibition of apoptosis
Q39876149Effect of Bcl-xL overexpression on apoptosis and autophagy in recombinant Chinese hamster ovary cells under nutrient-deprived condition
Q34473662Elongation factor-2 kinase regulates TG2/β1 integrin/Src/uPAR pathway and epithelial-mesenchymal transition mediating pancreatic cancer cells invasion
Q89522849Enabling Combinatorial siRNA Delivery against Apoptosis-Related Proteins with Linoleic Acid and α-Linoleic Acid Substituted Low Molecular Weight Polyethylenimines
Q36715054Endoplasmic reticulum stress sensitizes human esophageal cancer cell to radiation
Q39202309Functionalization of the 3'-ends of DNA and RNA strands with N-ethyl-N-coupled nucleosides: a promising approach to avoid 3'-exonuclease-catalyzed hydrolysis of therapeutic oligonucleotides.
Q37942090Harnessing the cell death pathway for targeted cancer treatment.
Q31143548Heteroleptic mononuclear compounds of ruthenium(ii): synthesis, structural analyses, in vitro antitumor activity and in vivo toxicity on zebrafish embryos
Q37299691IBP-mediated suppression of autophagy promotes growth and metastasis of breast cancer cells via activating mTORC2/Akt/FOXO3a signaling pathway
Q33925154Inhibition of active autophagy induces apoptosis and increases chemosensitivity in cholangiocarcinoma
Q39165527Inhibition of autophagy enhances cisplatin cytotoxicity in human adenoid cystic carcinoma cells of salivary glands
Q39079713Inhibition of autophagy induced by TSA sensitizes colon cancer cell to radiation
Q39681605Inhibition of isoprenylcysteine carboxylmethyltransferase induces autophagic-dependent apoptosis and impairs tumor growth
Q37295309Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development
Q36970527Is autophagy rather than apoptosis the regression driver in imatinib-treated gastrointestinal stromal tumors?
Q39602090JS-K, a nitric oxide-releasing prodrug, induces breast cancer cell death while sparing normal mammary epithelial cells
Q28297133Knockdown of PSMB7 induces autophagy in cardiomyocyte cultures: possible role in endoplasmic reticulum stress
Q41860362Low-Dose Endothelial-Monocyte-Activating Polypeptide-II Induced Autophagy by Down-Regulating miR-20a in U-87 and U-251 Glioma Cells
Q48857817MIR506 induces autophagy-related cell death in pancreatic cancer cells by targeting the STAT3 pathway
Q38833604Mechanisms of autophagy and apoptosis: Recent developments in breast cancer cells
Q98386353Mechanistic studies of cytotoxic activity of the mesoionic compound MIH 2.4Bl in MCF-7 breast cancer cells
Q37620713Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling
Q92445781Molecular Determinants of Cancer Therapy Resistance to HDAC Inhibitor-Induced Autophagy
Q36989867Mullerian inhibiting substance suppresses proliferation and induces apoptosis and autophagy in endometriosis cells in vitro.
Q90460482Nanoparticle Delivery of RIG-I Agonist Enables Effective and Safe Adjuvant Therapy in Pancreatic Cancer
Q35886625Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling
Q60949491New Insights into the Role of Endoplasmic Reticulum Stress in Breast Cancer Metastasis
Q37585057New function of type I IFN: induction of autophagy
Q40434898Noncanonical Fungal Autophagy Inhibits Inflammation in Response to IFN-γ via DAPK1.
Q37132233Potent antitumor activity of oncolytic adenovirus expressing Beclin-1 via induction of autophagic cell death in leukemia
Q53038645Progesterone increases apoptosis and inversely decreases autophagy in human hepatoma HA22T/VGH cells treated with epirubicin.
Q38265625Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer
Q36670905Removal of the BH4 domain from Bcl-2 protein triggers an autophagic process that impairs tumor growth
Q92916951Role of Autophagy in Breast Cancer Development and Progression: Opposite Sides of the Same Coin
Q37368042Role of apoptosis in cardiovascular disease
Q38120523Role of the Crosstalk between Autophagy and Apoptosis in Cancer
Q37696302Sequential delivery of therapeutic agents using a rationally designed disulfide-linked glycolipid-like nanocarrier
Q24632721Silencing of p130cas in ovarian carcinoma: a novel mechanism for tumor cell death
Q34989052Silencing of the IKKε gene by siRNA inhibits invasiveness and growth of breast cancer cells
Q37152867Spindle and kinetochore associated complex subunit 1 regulates the proliferation of oral adenosquamous carcinoma CAL-27 cells in vitro
Q36009215Steroid receptor coactivator 3 regulates autophagy in breast cancer cells through macrophage migration inhibitory factor
Q33635355Stimuli-Responsive Mesoporous Silica NPs as Non-viral Dual siRNA/Chemotherapy Carriers for Triple Negative Breast Cancer
Q38959517Tackling breast cancer chemoresistance with nano-formulated siRNA.
Q36416427Targeted polymeric nanoparticles for cancer gene therapy
Q34387697Targeted silencing of elongation factor 2 kinase suppresses growth and sensitizes tumors to doxorubicin in an orthotopic model of breast cancer
Q49545616Targeting Autophagy in ALK-Associated Cancers.
Q39706185Targeting Bcl-2-mediated cell death as a novel therapy in pancreatic cancer
Q64977661Targeting Protein Quality Control Mechanisms by Natural Products to Promote Healthy Ageing.
Q34023616Targeting autophagy in breast cancer.
Q26782468Targeting autophagy in cancer management - strategies and developments
Q39066768Targeting elongation factor-2 kinase (eEF-2K) induces apoptosis in human pancreatic cancer cells
Q38671036Targeting mitotic pathways for endocrine-related cancer therapeutics
Q37707832Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer
Q38874839The PARP inhibitor AZD2281 (Olaparib) induces autophagy/mitophagy in BRCA1 and BRCA2 mutant breast cancer cells.
Q38861044The Phytoestrogen Genistein Affects Breast Cancer Cells Treatment Depending on the ERα/ERβ Ratio.
Q37902052The autophagic paradox in cancer therapy
Q34275855The importance of autophagy regulation in breast cancer development and treatment.
Q57291210The multifaceted role of autophagy in cancer and the microenvironment
Q37378496The paradox of autophagy and its implication in cancer etiology and therapy
Q37553966The role of X-box binding protein-1 in tumorigenicity.
Q33637380Therapeutic Silencing of Bcl-2 by Systemically Administered siRNA Nanotherapeutics Inhibits Tumor Growth by Autophagy and Apoptosis and Enhances the Efficacy of Chemotherapy in Orthotopic Xenograft Models of ER (-) and ER (+) Breast Cancer
Q36243019Time depended Bcl-2 inhibition might be useful for a targeted drug therapy.
Q28395046Toxicological considerations when creating nanoparticle-based drugs and drug delivery systems
Q36685448Tumor growth suppression by inhibiting both autophagy and STAT3 signaling in HNSCC.
Q38840273miR-15a enhances the anticancer effects of cisplatin in the resistant non-small cell lung cancer cells
Q55413938miR-519a enhances chemosensitivity and promotes autophagy in glioblastoma by targeting STAT3/Bcl2 signaling pathway.

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