Systemic osteoprotegerin gene therapy restores tumor-induced bone loss in a therapeutic model of breast cancer bone metastasis

scientific article

Systemic osteoprotegerin gene therapy restores tumor-induced bone loss in a therapeutic model of breast cancer bone metastasis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/MT.2008.48
P698PubMed publication ID18388919
P5875ResearchGate publication ID5463471

P50authorVishnu V B ReddyQ39995100
Kurt R. ZinnQ39995144
Gene P. SiegalQ93491237
P2093author name stringDiptiman Chanda
Selvarangan Ponnazhagan
Tatyana Isayeva
Sanjay Kumar
April A Szafran
P2860cites workOsteoprotegerin: a novel secreted protein involved in the regulation of bone densityQ24313918
Key roles of the OPG-RANK-RANKL system in bone oncologyQ28287394
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Breast cancer metastasis to bone: mechanisms of osteolysis and implications for therapyQ30437441
Gene therapy with human osteoprotegerin decreases callus remodeling with limited effects on biomechanical propertiesQ33223536
Mechanisms of bone metastasisQ33977526
Adeno-associated virus vectors: potential applications for cancer gene therapyQ36165834
Mechanisms of disease: roles of OPG, RANKL and RANK in the pathophysiology of skeletal metastasis.Q36366450
Role of osteoprotegerin (OPG) in cancerQ36389753
The RANK/RANKL/OPG triad in cancer-induced bone diseasesQ36688664
The bone microenvironment in metastasis; what is special about bone?Q37028803
Osteoprotegerin inhibits prostate cancer-induced osteoclastogenesis and prevents prostate tumor growth in the boneQ39946634
Inhibition of bone resorption, rather than direct cytotoxicity, mediates the anti-tumour actions of ibandronate and osteoprotegerin in a murine model of breast cancer bone metastasis.Q40210622
Osteoprotegerin overexpression by breast cancer cells enhances orthotopic and osseous tumor growth and contrasts with that delivered therapeutically.Q40296427
Regulation of cancer cell migration and bone metastasis by RANKL.Q40298349
Osteoprotegerin (OPG) expression by breast cancer cells in vitro and breast tumours in vivo--a role in tumour cell survival?Q40374890
The inhibition of RANKL causes greater suppression of bone resorption and hypercalcemia compared with bisphosphonates in two models of humoral hypercalcemia of malignancy.Q40432075
A helper virus-free packaging system for recombinant adeno-associated virus vectorsQ40916579
Lack of site-specific integration of the recombinant adeno-associated virus 2 genomes in human cellsQ41128137
A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastasesQ44291815
Novel and selective small molecule stimulators of osteoprotegerin expression inhibit bone resorptionQ44725393
Adeno-associated virus-mediated osteoprotegerin gene transfer protects against particulate polyethylene-induced osteolysis in a murine modelQ45730626
Recombinant adeno-associated virus purification using novel methods improves infectious titer and yieldQ45747699
Effects of sustained antiangiogenic therapy in multistage prostate cancer in TRAMP modelQ45868850
Therapeutic relevance of osteoprotegerin gene therapy in osteosarcoma: blockade of the vicious cycle between tumor cell proliferation and bone resorptionQ45869910
Gene therapy with human recombinant osteoprotegerin reverses established osteopenia in ovariectomized miceQ45874107
Osteoprotegerin in prostate cancer bone metastasis.Q51531894
Breast cancer cells induce osteoblast apoptosis: a possible contributor to bone degradation.Q51719076
The effect of zoledronic acid and osteoprotegerin on growth of human lung cancer in the tibias of nude mice.Q53621774
P433issue5
P921main subjectgene therapyQ213901
P304page(s)871-878
P577publication date2008-03-18
P1433published inMolecular TherapyQ15762400
P1476titleSystemic osteoprotegerin gene therapy restores tumor-induced bone loss in a therapeutic model of breast cancer bone metastasis
P478volume16

Reverse relations

cites work (P2860)
Q3714866989Zr-Radiolabeled Trastuzumab Imaging in Orthotopic and Metastatic Breast Tumors
Q39030024Colony-stimulating factor 1 potentiates lung cancer bone metastasis
Q36240183Comparative Effects of Ibandronate and Paclitaxel on Immunocompetent Bone Metastasis Model.
Q37658767Emerging therapeutic targets in breast cancer bone metastasis
Q36571484Importance of osteoprotegrin and receptor activator of nuclear factor κB in breast cancer response to hepatocyte growth factor and the bone microenvironment in vitro
Q34473019Musculoskeletal molecular imaging: a comprehensive overview
Q36296474Oncostatin m promotes mammary tumor metastasis to bone and osteolytic bone degradation
Q34998448Osteoprotegerin expression in triple-negative breast cancer cells promotes metastasis
Q26748804Osteoprotegerin rich tumor microenvironment: implications in breast cancer
Q54391573Osteoprotegerin, a new actor in vasculogenesis, stimulates endothelial colony-forming cells properties.
Q37199218RANK, RANKL and osteoprotegerin in bone biology and disease.
Q60917149RANKL/RANK/OPG system beyond bone remodeling: involvement in breast cancer and clinical perspectives
Q57801311Receptor activator of nuclear factor kB ligand, osteoprotegerin, and risk of death following a breast cancer diagnosis: results from the EPIC cohort
Q34147824Therapeutic potential of adult bone marrow-derived mesenchymal stem cells in prostate cancer bone metastasis

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