Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing.

scientific article

Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.5245-07.2008
P932PMC publication ID6671193
P698PubMed publication ID18322105
P5875ResearchGate publication ID5530470

P2093author name stringLi Liu
Lili Wang
Yi Wen
Emmanuel Planel
Karen E Duff
Lit-Fui Lau
Helen Y Figueroa
Wai Haung Yu
Mathieu Herman
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Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia.Q48232865
Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survivalQ48271519
Cdk5 is a key factor in tau aggregation and tangle formation in vivoQ48300530
p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathwayQ48401217
The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylationQ48486318
A serine/threonine proline kinase activity is included in the tau protein kinase fraction forming a paired helical filament epitopeQ48687234
ELISA method for measurement of amyloid-beta levels.Q48832225
Tissue processing prior to protein analysis and amyloid-beta quantitation.Q48832234
Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory.Q50951137
Neuregulin 1-erbB signaling is necessary for normal myelination and sensory function.Q52022659
p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo.Q53594164
Glycogen synthase kinase-3 beta is a dual specificity kinase differentially regulated by tyrosine and serine/threonine phosphorylation.Q54633263
Schizophrenia genes - famine to feastQ79912937
Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophreniaQ24293245
Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3betaQ28139977
GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptidesQ28205921
Control of peripheral nerve myelination by the beta-secretase BACE1Q28264800
Hyperphosphorylation of tau in PHFQ28289907
Tyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor: 4-(phenylamino)quinazoline- and 4-(phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides bearing additional solubilizing functionsQ28375843
Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junctionQ28575776
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase BalphaQ28616168
Wnt signaling: a common theme in animal developmentQ29547527
The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3Q29614380
Phosphatidylinositol-3 kinase dependent pathways: the role in control of cell growth, survival, and malignant transformation.Q33854281
Phosphoinositide 3-kinase controls early and late events in mammalian cell divisionQ34410971
Tau neurofibrillary pathology and microtubule stabilityQ35050284
Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5Q35084361
The regulation of cyclin-dependent kinase 5 activity through the metabolism of p35 or p39 Cdk5 activatorQ35606861
Cyclin-dependent kinase-5 in neurodegeneration.Q35686119
Co-localization of glycogen synthase kinase-3 with neurofibrillary tangles and granulovacuolar degeneration in transgenic miceQ35791996
MARKing tau for tangles and toxicity.Q35902808
Her-2 targeted therapy: beyond breast cancer and trastuzumabQ36409209
Neuregulin-1 and myelinationQ36416058
Neuregulins and their receptorsQ36793133
The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's diseaseQ38611694
Networking with proline-directed protein kinases implicated in tau phosphorylationQ40416700
Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation eventQ40624453
A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neuronsQ40901890
PI3K: downstream AKTion blocks apoptosisQ41351876
Physiology and pathology of tau protein kinases in relation to Alzheimer's disease.Q41412181
Inhibition of protein phosphatase 2A overrides tau protein kinase I/glycogen synthase kinase 3 beta and cyclin-dependent kinase 5 inhibition and results in tau hyperphosphorylation in the hippocampus of starved mouseQ43664665
Analysis of polymorphisms in AT-rich domains of neuregulin 1 gene in schizophrenia.Q43853288
Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation.Q46097064
Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophreniaQ46775363
Decreased cyclin-dependent kinase 5 (cdk5) activity is accompanied by redistribution of cdk5 and cytoskeletal proteins and increased cytoskeletal protein phosphorylation in p35 null mice.Q48139851
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)2624-2632
P577publication date2008-03-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleInterplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing
P478volume28

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