Regulation of mTORC1 signaling by Src kinase activity is Akt1-independent in RSV-transformed cells

scientific article published on February 2008

Regulation of mTORC1 signaling by Src kinase activity is Akt1-independent in RSV-transformed cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1593/NEO.07905
P932PMC publication ID2244684
P698PubMed publication ID18283331
P5875ResearchGate publication ID237831806

P50authorJiří VachtenheimQ59694164
P2093author name stringEva Sloncová
Martina Vojtechová
Zdena Tuhácková
Dana Kucerová
Jolana Turecková
P2860cites workRapamycin-resistant phosphorylation of the initiation factor-4E-binding protein (4E-BP1) in v-SRC-transformed hamster fibroblastsQ39438481
Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibitionQ40164038
Regulation of c-Src activity by the expression of wild-type v-Src and its kinase-dead double Y416F-K295N mutantQ40217084
Receptor association and tyrosine phosphorylation of S6 kinases.Q40287436
Active Src elevates the expression of beta-catenin by enhancement of cap-dependent translationQ40415667
Initiation factor eIF2B not p70 S6 kinase is involved in the activation of the PI‐3K signalling pathway induced by the v‐src oncogeneQ40647038
The Src-family tyrosine kinase inhibitor PP1 interferes with the activation of ribosomal protein S6 kinasesQ40731630
Insulin-like growth factor-mediated muscle differentiation: collaboration between phosphatidylinositol 3-kinase-Akt-signaling pathways and myogeninQ40786763
Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinaseQ42524332
Construction and characterization of a conditionally active version of the serine/threonine kinase Akt.Q42829358
Akt up-regulation increases resistance to microtubule-directed chemotherapeutic agents through mammalian target of rapamycin.Q45213258
Complexity of the TOR signaling networkQ46975015
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complexQ24295120
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeletonQ24299873
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinaseQ24300915
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machineryQ24302549
PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complexQ24316314
Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioningQ24320102
SU6656, a selective src family kinase inhibitor, used to probe growth factor signalingQ24551043
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinaseQ24564747
AKT/PKB signaling: navigating downstreamQ24657857
Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancerQ27824855
TOR signaling in growth and metabolismQ27860757
Regulation of Akt/PKB activation by tyrosine phosphorylationQ28205568
The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stressesQ28240102
Rheb binds and regulates the mTOR kinaseQ28247033
Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinaseQ28251385
Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinaseQ28251762
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKBQ28306356
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward RhebQ28646935
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates AktQ29547767
Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activationQ30164872
Survival signalling by Akt and eIF4E in oncogenesis and cancer therapyQ34306865
Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition.Q34443426
In vitro and in vivo activity of SKI-606, a novel Src-Abl inhibitor, against imatinib-resistant Bcr-Abl+ neoplastic cellsQ34582817
Cellular transformation and activation of the phosphoinositide-3-kinase-Akt cascade by the ETV6-NTRK3 chimeric tyrosine kinase requires c-SrcQ34616022
Signaling control of mRNA translation in cancer pathogenesisQ35750101
Tyrosine kinase inhibitor AG1024 exerts antileukaemic effects on STI571-resistant Bcr-Abl expressing cells and decreases AKT phosphorylation.Q36695924
A new mutational AKTivation in the PI3K pathwayQ36907930
P433issue2
P304page(s)99-107
P577publication date2008-02-01
P1433published inNeoplasiaQ2962042
P1476titleRegulation of mTORC1 signaling by Src kinase activity is Akt1-independent in RSV-transformed cells
P478volume10

Reverse relations

cites work (P2860)
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