Synthesis and biological evaluation of isosteric analogues of FK866, an inhibitor of NAD salvage.

scientific article published on May 2008

Synthesis and biological evaluation of isosteric analogues of FK866, an inhibitor of NAD salvage. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/CMDC.200700311
P698PubMed publication ID18247435
P5875ResearchGate publication ID5605657

P50authorArmando A. GenazzaniQ39185102
Richard BillingtonQ42891584
P2093author name stringPier Luigi Canonico
Gian Cesare Tron
Ubaldina Galli
Emanuela Ercolano
Giovanni Sorba
Lorenzo Carraro
Cintia R Blasi Roman
P2860cites workThe power to reduce: pyridine nucleotides--small molecules with a multitude of functionsQ24675007
Enzymology of NAD+ homeostasis in man.Q27863325
Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humansQ27937147
A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynesQ28219495
An Improved One-pot Procedure for the Synthesis of Alkynes from AldehydesQ29304543
The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitorQ33376941
Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azidesQ33958790
The growing impact of click chemistry on drug discoveryQ33974618
Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discoveryQ34003813
Ruthenium-catalyzed cycloaddition of alkynes and organic azidesQ34467516
Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents.Q34539655
Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistryQ40086230
Iodine(V) reagents in organic synthesis. Part 4. o-Iodoxybenzoic acid as a chemospecific tool for single electron transfer-based oxidation processesQ43657679
Metabolic signatures associated with a NAD synthesis inhibitor-induced tumor apoptosis identified by 1H-decoupled-31P magnetic resonance spectroscopyQ46469025
Click-Chemie: diverse chemische Funktionalität mit einer Handvoll guter ReaktionenQ74020281
Practical synthesis of (Z)-polyaromatic and heteroaromatic vinylacetylenesQ81855478
Second messenger function of nicotinic acid adenine dinucleotide phosphate revealed by an improved enzymatic cycling assayQ83181175
P433issue5
P304page(s)771-779
P577publication date2008-05-01
P1433published inChemMedChemQ2962252
P1476titleSynthesis and biological evaluation of isosteric analogues of FK866, an inhibitor of NAD salvage
P478volume3

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cites work (P2860)
Q91866799Controlling cellular distribution of drugs with permeability modifying moieties
Q39659133From BACE1 inhibitor to multifunctionality of tryptoline and tryptamine triazole derivatives for Alzheimer's disease
Q58044476Identification of a novel NAMPT inhibitor by combinatorial click chemistry and chemical refinement
Q28542558Metabolomics analysis of metabolic effects of nicotinamide phosphoribosyltransferase (NAMPT) inhibition on human cancer cells
Q37504699Molecular and cellular mechanisms of CLL: novel therapeutic approaches.
Q38005192PBEF/NAMPT/visfatin: a promising drug target for treating rheumatoid arthritis?
Q36579595Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, in human cancer cells: metabolic basis and potential clinical implications
Q43966731Platinum catalysed hydrosilylation of propargylic alcohols.
Q33422176Preclinical models of nicotinamide phosphoribosyltransferase inhibitor-mediated hematotoxicity and mitigation by co-treatment with nicotinic acid
Q34482044Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase.
Q43160144Weak coupling of ATP hydrolysis to the chemical equilibrium of human nicotinamide phosphoribosyltransferase

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