Functional effects of a natural polymorphism in the transcriptional regulatory sequence of HLA-DQB1.

scientific article published on September 1995

Functional effects of a natural polymorphism in the transcriptional regulatory sequence of HLA-DQB1. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MCB.15.9.4771
P8608Fatcat IDrelease_tv7rwjl5fvgwjb52ty5bfky5oy
P932PMC publication ID230721
P698PubMed publication ID7651394

P50authorGerald T NepomQ38546281
P2093author name stringK A West
J S Beaty
P2860cites workComplementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)Q24317711
A novel cysteine-rich sequence-specific DNA-binding protein interacts with the conserved X-box motif of the human major histocompatibility complex class II genes via a repeated Cys-His domain and functions as a transcriptional repressorQ24337320
The DNA-binding defect observed in major histocompatibility complex class II regulatory mutants concerns only one member of a family of complexes binding to the X boxes of class II promotersQ24601467
Primer-directed enzymatic amplification of DNA with a thermostable DNA polymeraseQ26778389
57 Sequencing end-labeled DNA with base-specific chemical cleavagesQ27860479
A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoterQ28119099
Dideoxy sequencing method using denatured plasmid templatesQ29620525
In vivo footprinting of a muscle specific enhancer by ligation mediated PCR.Q34550385
Sequences and factors: a guide to MHC class-II transcriptionQ36135151
Allelic polymorphism in transcriptional regulatory regions of HLA-DQB genesQ36229768
YB-1 DNA-binding protein represses interferon gamma activation of class II major histocompatibility complex genesQ36363138
Affinity enrichment and functional characterization of TRAX1, a novel transcription activator and X1-sequence-binding protein of HLA-DRAQ36566714
Functional complementation of major histocompatibility complex class II regulatory mutants by the purified X-box-binding protein RFX.Q36667891
Differential transcriptional activities of HLA-DR genes in the various haplotypes.Q36727137
Transcriptional regulation of the HLA-DRA geneQ37420892
Delineation of a previously unrecognized cis-acting element required for HLA class II gene expressionQ37625423
CCAAT box binding protein NF-Y facilitates in vivo recruitment of upstream DNA binding transcription factorsQ37635758
Magnitude of response of histocompatibility-restricted T-cell clones is a function of the product of the concentrations of antigen and Ia moleculesQ37690264
Regulation of major histocompatibility complex class-II genes: X, Y and other letters of the alphabetQ37813554
Transcriptional regulation of HLA class-II genesQ37827090
A unified hypothesis for the complex genetics of HLA associations with IDDM.Q37958513
Identification of a nuclear factor that binds to a conserved sequence of the I-A beta geneQ38347184
The class II molecules of the human and murine major histocompatibility complex.Q40108949
Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donorQ40170620
High level transient expression of a chloramphenicol acetyl transferase gene by DEAE-dextran mediated DNA transfection coupled with a dimethyl sulfoxide or glycerol shock treatment.Q40461112
HLA class II nucleotide sequences, 1992.Q41108588
Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA.Q41457392
Structure and evolution of the promoter regions of the DQA genesQ41581174
Locus- and allele-specific DNA-protein interactions in the HLA-DQB1 X box.Q41585701
The X boxes from promoters of HLA class II B genes at different loci do not complete for nuclear protein-specific bindingQ41756248
The relation between major histocompatibility complex (MHC) restriction and the capacity of Ia to bind immunogenic peptidesQ42074920
Differential susceptibility to recombinant interferon-gamma-induced HLA-DQ antigen modulation among clones from a human metastatic melanomaQ42820854
HLA-DQ molecules form alpha-beta heterodimers of mixed allotype.Q43419138
Congenital immunodeficiency with a regulatory defect in MHC class II gene expression lacks a specific HLA-DR promoter binding protein, RF-X.Q43434628
HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitusQ46138865
Structural constraints within a trimeric transcriptional regulatory region. Constitutive and interferon-gamma-inducible expression of the HLA-DRA geneQ48147793
T cell tolerance by clonal elimination in the thymusQ56922465
The nucleotide sequence of bovine MHC class IIDQB andDRB genesQ58018688
DNA loopingQ68008374
Interaction of protein with DNA in vitroQ68190484
A high-efficiency HeLa cell nuclear transcription extractQ68287469
A nonchromatographic assay for expression of the chloramphenicol acetyltransferase gene in eucaryotic cellsQ68733304
Quantitation of changes in the expression of multiple genes by simultaneous polymerase chain reactionQ71607890
Cooperative binding between factors RFX and X2bp to the X and X2 boxes of MHC class II promotersQ72108061
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)4771-4782
P577publication date1995-09-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleFunctional effects of a natural polymorphism in the transcriptional regulatory sequence of HLA-DQB1.
P478volume15

Reverse relations

cites work (P2860)
Q29614592A genome-wide association study of global gene expression
Q40382442A population genetics study of the familial Mediterranean fever gene: evidence of balancing selection under an overdominance regime
Q40549548Allele-specific quantification of HLA-DQB1 gene expression by real-time reverse transcriptase-polymerase chain reaction
Q44567625Allelic combinations of promoter and exon 2 in DQB1 in dogs and wolves
Q33805301Allelic variation in transcription modulates MHC class II expression and function.
Q34399008An ancient balanced polymorphism in a regulatory region of human major histocompatibility complex is retained in Chinese minorities but lost worldwide
Q54588405Analysis of HLA-DQB1 gene polymorphisms in asymptomatic HBV carriers and chronic hepatitis B patients in the Chinese Han population.
Q47616088DQA1 and DQB1 promoter diversity and linkage disequilibrium with class II haplotypes in Mexican Mestizo population
Q36408225DQB1*06:02 allele-specific expression varies by allelic dosage, not narcolepsy status
Q40992272Different binding of NF-Y transcriptional factor to DQA1 promoter variants.
Q51829106Differential expression of HLA-DQ alleles in peripheral blood mononuclear cells: alleles associated with susceptibility to and protection from autoimmune type 1 diabetes.
Q41107362Differential expression of insulin‐dependent diabetes mellitus‐associated HLA‐DQA1 alleles in vivo
Q36500075Differential expression of major histocompatibility complex class II genes on murine macrophages associated with T cell cytokine profile and protective/suppressive effects.
Q78023745Differential surface expression of HLA-DRB1 and HLA-DRB4 among peripheral blood cells of DR4 positive individuals
Q38318899EBP1 and DRBP76/NF90 binding proteins are included in the major histocompatibility complex class II RNA operon.
Q58859993Evaluation of DLA promoters in Doberman hepatitis
Q41329213Functional significance of polymorphism among MHC class II gene promoters
Q33649933Genetics of allergy and asthma
Q33669033Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions
Q33322678Genomic analysis of Ovis aries (Ovar) MHC class IIa loci
Q34658850High natural gene expression variation in the reef-building coral Acropora millepora: potential for acclimative and adaptive plasticity
Q73323736Idiomatic (gene) expressions
Q91583430Integrative phenotypic and gene expression data identify myostatin as a muscle growth inhibitor in Chinese shrimp Fenneropenaeus chinensis
Q38346805Intestinal transcription and synthesis of apolipoprotein AI is regulated by five natural polymorphisms upstream of the apolipoprotein CIII gene
Q35997212Mapping complex disease traits with global gene expression
Q24645332Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions
Q48054345Polymorphic MHC class II promoters exhibit distinct expression pattern in various antigen-presenting cell lines
Q41118738Polymorphism in the 5' terminal region of the mRNA of HLA-DQA1 gene: identification of four groups of transcripts and their association with polymorphism in the alpha 1 domain
Q77637924Polymorphism in the Y box controls level of cytokine-mediated expression of HLA-DRB1 genes
Q34330648Regulation of major histocompatibility complex class II gene expression, genetic variation and disease
Q34042021Screen and clean: a tool for identifying interactions in genome-wide association studies
Q38985750Sequence and Phylogenetic Analysis of the Untranslated Promoter Regions for HLA Class I Genes
Q51380346Sequence variations in the transcriptional regulatory region and intron1 of HLA-DQB1 gene and their linkage in southern Chinese ethnic groups.
Q40625008The IDDM-associated solitary retroviral promoters DQ-LTR3 and DQ-LTR13 have a distinct impact on the expression of selected DQB1 genes in different cell lines in vitro
Q57471115The MHC in the Era of Next-Generation Sequencing: Implications for Bridging Structure with Function
Q40532153The S box of major histocompatibility complex class II promoters is a key determinant for recruitment of the transcriptional co-activator CIITA.
Q36993031The signature of long-standing balancing selection at the human defensin beta-1 promoter.
Q74758308Variation in gene expression within and among natural populations

Search more.