Down-regulation of androgen-receptor and PSA by phytochemicals

scientific article published on February 2008

Down-regulation of androgen-receptor and PSA by phytochemicals is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID2586941
P698PubMed publication ID18202763

P50authorZbyszek DarzynkiewiczQ33103772
Sophie ChenQ45323024
Frank TraganosQ77609899
P2093author name stringJian Gao
H Dorota Halicka
P2860cites workNF-kappaB activation upregulates fibroblast growth factor 8 expression in prostate cancer cellsQ24336679
Non-steroidal anti-inflammatory drug use and prostate cancer in a high-risk populationQ28195592
Regression of mouse prostatic intraepithelial neoplasia by nonsteroidal anti-inflammatory drugs in the transgenic adenocarcinoma mouse prostate modelQ28210937
NF-kappaB activation in human prostate cancer: important mediator or epiphenomenon?Q28235522
Molecular determinants of resistance to antiandrogen therapyQ28236889
Antiproliferation effects of oridonin on HPB-ALL cells and its mechanisms of actionQ33232382
Isoliquiritigenin induces apoptosis by depolarizing mitochondrial membranes in prostate cancer cells.Q33235488
Oridonin inhibits cell growth by induction of apoptosis on human hepatocelluar carcinoma BEL-7402 cellsQ33241115
Functionality of androgen receptor-based gene expression imaging in hormone refractory prostate cancerQ33650205
Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1.Q33960065
Chinese herbal mixture PC SPES in treatment of prostate cancer (review).Q34038207
Prospective, multicenter, randomized phase II trial of the herbal supplement, PC-SPES, and diethylstilbestrol in patients with androgen-independent prostate cancer.Q34338135
PC-SPES: herbal formulation for prostate cancerQ34914418
Androgen receptor remains critical for cell-cycle progression in androgen-independent CWR22 prostate cancer cellsQ35221988
Androgen receptor decoy molecules block the growth of prostate cancerQ35611734
The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 2: Androgen-receptor cofactors and bypass pathwaysQ36126920
Inhibition of the Akt, cyclooxygenase-2, and matrix metalloproteinase-9 pathways in combination with androgen deprivation therapy: potential therapeutic approaches for prostate cancer.Q36207417
Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axisQ36309725
Mechanisms leading to the development of hormone-resistant prostate cancerQ36456488
Drug insight: role of the androgen receptor in the development and progression of prostate cancerQ36773464
Inappropriate activation of the androgen receptor by nonsteroids: involvement of the Src kinase pathway and its therapeutic implicationsQ38307975
Androgens regulate the immune/inflammatory response and cell survival pathways in rat ventral prostate epithelial cellsQ38320457
Cyclooxygenase-2 (COX-2) expression is an independent predictor of prostate cancer recurrenceQ38438329
Androgen receptor or estrogen receptor-beta blockade alters DHEA-, DHT-, and E(2)-induced proliferation and PSA production in human prostate cancer cellsQ40132800
Phytoestrogens from Belamcanda chinensis regulate the expression of steroid receptors and related cofactors in LNCaP prostate cancer cellsQ40135223
Down-regulation of androgen receptor by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in both hormone-sensitive LNCaP and insensitive C4-2B prostate cancer cellsQ40218951
Ligand-independent androgen receptor activity is activation function-2-independent and resistant to antiandrogens in androgen refractory prostate cancer cellsQ40251128
Androgen-dependent regulation of Her-2/neu in prostate cancer cellsQ40272793
Evolution of the androgen receptor pathway during progression of prostate cancer.Q40278784
Polyphenols purified from the Brazilian aroeira plant (Schinus terebinthifolius, Raddi) induce apoptotic and autophagic cell death of DU145 cells.Q40316961
Role of coordinated molecular alterations in the development of androgen-independent prostate cancer: an in vitro model that corroborates clinical observationsQ40342379
Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathwaysQ40435902
Requirement for NF-(kappa)B in interleukin-4-induced androgen receptor activation in prostate cancer cells.Q40464312
Baicalein, a component of Scutellaria radix from Huang-Lian-Jie-Du-Tang (HLJDT), leads to suppression of proliferation and induction of apoptosis in human myeloma cells.Q40475869
Oridonin induces growth inhibition and apoptosis of a variety of human cancer cells.Q40636149
Baicalin is a major component of PC-SPES which inhibits the proliferation of human cancer cells via apoptosis and cell cycle arrestQ40762945
Effects of a phytotherapeutic agent, PC-SPES, on prostate cancer: a preliminary investigation on human cell lines and patientsQ40921601
Regulation of androgen receptor (AR) and prostate specific antigen (PSA) expression in the androgen-responsive human prostate LNCaP cells by ethanolic extracts of the Chinese herbal preparation, PC-SPES.Q41101601
PC-SPES: a unique inhibitor of proliferation of prostate cancer cells in vitro and in vivo .Q41714789
In vitro mechanism of PC SPES.Q43705356
Effects of the flavonoid baicalin and its metabolite baicalein on androgen receptor expression, cell cycle progression and apoptosis of prostate cancer cell linesQ43759636
In vivo effect of PC-SPES on prostate growth and hepatic CYP3A expression in ratsQ44391274
The cytostatic and cytotoxic effects of oridonin (Rubescenin), a diterpenoid from Rabdosia rubescens, on tumor cells of different lineage.Q45259728
Prospective trial of the herbal supplement PC-SPES in patients with progressive prostate cancerQ46117080
Chemical ablation of androgen receptor in prostate cancer cells by the histone deacetylase inhibitor LAQ824.Q46709554
Skullcapflavone I from Scutellaria baicalensis induces apoptosis in activated rat hepatic stellate cellsQ46736843
Arachidonic acid activates phosphatidylinositol 3-kinase signaling and induces gene expression in prostate cancerQ46923183
Constitutive activation of nuclear factor kappaB p50/p65 and Fra-1 and JunD is essential for deregulated interleukin 6 expression in prostate cancer.Q47938173
Effects of the herbal extract PC-SPES on microtubule dynamics and paclitaxel-mediated prostate tumor growth inhibition.Q52548183
Blockade of cytokine-induced endothelial cell adhesion molecule expression by licorice isoliquiritigenin through NF-kappaB signal disruption.Q52576601
RNA interference-mediated cyclooxygenase-2 inhibition prevents prostate cancer cell growth and induces differentiation: modulation of neuronal protein synaptophysin, cyclin D1, and androgen receptor.Q53345643
Androgen receptor outwits prostate cancer drugs.Q53907010
Regulation of I B Kinase Expression by the Androgen Receptor and the Nuclear Factor- B Transcription Factor in Prostate CancerQ58325218
Activity of the herbal combination, PC-SPES, in the treatment of patients with androgen-independent prostate cancerQ60156355
Clinical and biologic activity of an estrogenic herbal combination (PC-SPES) in prostate cancerQ77300267
Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human aortic smooth muscle cellsQ79277670
Effects of wogonin on the levels of cytokines and functions of leukocytes associated with NF-kappa B expression in Sprague-Dawley ratsQ80090555
Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancerQ80352321
American Society of Clinical Oncology recommendations for the initial hormonal management of androgen-sensitive metastatic, recurrent, or progressive prostate cancerQ81725224
P433issue2
P921main subjectphytochemistryQ640068
P304page(s)405-411
P577publication date2008-02-01
P1433published inInternational Journal of OncologyQ6051527
P1476titleDown-regulation of androgen-receptor and PSA by phytochemicals
P478volume32