Differential effects of staurosporine analogues on cell cycle, growth and viability in A549 cells

scientific article published on October 1996

Differential effects of staurosporine analogues on cell cycle, growth and viability in A549 cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/BJC.1996.517
P932PMC publication ID2075912
P698PubMed publication ID8883405
P5875ResearchGate publication ID14324310

P2093author name stringGescher A
Snowden R
Courage C
P2860cites workCell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cellsQ72078498
The role of protein kinase C isoenzymes in the growth inhibition caused by bryostatin 1 in human A549 lung and MCF-7 breast carcinoma cellsQ72253853
Staurosporine blocks cell progression through G1 between the cyclin D and cyclin E restriction pointsQ72522966
Diverse effects of indolocarbazole compounds on the cell cycle progression of ras-transformed rat fibroblast cellsQ72680385
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase CQ28327651
Potent and specific inhibitors of protein kinase C of microbial originQ35307811
Animal cell cycles and their controlQ35671048
Signalling targets for anticancer drug developmentQ37215680
Transformed mammalian cells are deficient in kinase-mediated control of progression through the G1 phase of the cell cycleQ37585411
Biology of the protein kinase C familyQ38773880
UCN-01, 7-hydroxyl-staurosporine, inhibits kinase activity of cyclin-dependent kinases and reduces the phosphorylation of the retinoblastoma susceptibility gene product in A549 human lung cancer cell lineQ41226364
Comparison of ability of protein kinase C inhibitors to arrest cell growth and to alter cellular protein kinase C localisationQ41354263
The protein kinase C inhibitor CGP 41251, a staurosporine derivative with antitumor activity, reverses multidrug resistance.Q41478368
Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha.Q41579047
Staurosporine is a potent inhibitor of p34cdc2 and p34cdc2-like kinasesQ41628594
Dianilinophthalimides: potent and selective, ATP-competitive inhibitors of the EGF-receptor protein tyrosine kinaseQ42800011
A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and in vitro anti-proliferative as well as in vivo anti-tumor activityQ44497906
Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor modelsQ44781213
Inhibitors of protein kinase C. 2. Substituted bisindolylmaleimides with improved potency and selectivityQ57005049
Highly synchronous culture of fibroblasts from G2 block caused by staurosporine, a potent inhibitor of protein kinasesQ57228862
Tyrosine kinase activity in breast cancer, benign breast disease, and normal breast tissueQ69936029
Antitumor effect of CGP41251, a new selective protein kinase C inhibitor, on human non-small cell lung cancer cellsQ71569301
Effect of UCN-01, a selective inhibitor of protein kinase C, on the cell-cycle distribution of human epidermoid carcinoma, A431 cellsQ71605859
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)1199-1205
P577publication date1996-10-01
P1433published inBritish Journal of CancerQ326309
P1476titleDifferential effects of staurosporine analogues on cell cycle, growth and viability in A549 cells
P478volume74

Reverse relations

cites work (P2860)
Q42538398Analogs of staurosporine: potential anticancer drugs?
Q40771101Anti-proliferative effects of new staurosporine derivatives isolated from a marine ascidian and its predatory flatworm
Q32079496Antitumor activity of benzamide riboside and its combination with cisplatin and staurosporine
Q35143997CDK inhibitors in clinical development for the treatment of cancer
Q28364520ColonyArea: an ImageJ plugin to automatically quantify colony formation in clonogenic assays
Q52183598Dysmorphogenic effects of a specific protein kinase C inhibitor during neurulation.
Q73149086Pharmacological inhibition of protein kinase C activity could induce apoptosis in gastric cancer cells by differential regulation of apoptosis-related genes
Q36075195Review of UCN-01 development: a lesson in the importance of clinical pharmacology
Q40940246Screening of five specific cell cycle inhibitors using a T cell lymphoma cell line synchrony/release assay
Q47927433Simultaneous cross-linking of CD6 and CD28 induces cell proliferation in resting T cells
Q58574978Staurosporine Induces the Generation of Polyploid Giant Cancer Cells in Non-Small-Cell Lung Carcinoma A549 Cells
Q33912029Staurosporine analogues - pharmacological toys or useful antitumour agents?
Q39393487Tumor specific cytotoxicity of arctigenin isolated from herbal plant Arctium lappa L.
Q73905120UCN-01 enhances the in vitro toxicity of clinical agents in human tumor cell lines

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