FHL2 protein is a novel co-repressor of nuclear receptor Nur77.

scientific article published on 2 November 2011

FHL2 protein is a novel co-repressor of nuclear receptor Nur77. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M111.308999
P932PMC publication ID3247951
P698PubMed publication ID22049082

P50authorDirk GeertsQ39789957
P2093author name stringCarlie J M de Vries
Erik van der Wal
Claudia M van Tiel
Kondababu Kurakula
P2860cites workThe LIM-only protein FHL2 is a negative regulator of E4F1Q24323174
The NR4A subgroup: immediate early response genes with pleiotropic physiological rolesQ24540372
FHL2, a novel tissue-specific coactivator of the androgen receptorQ24601620
The NR4A orphan nuclear receptor NOR1 is induced by platelet-derived growth factor and mediates vascular smooth muscle cell proliferationQ24677863
Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptorsQ27641344
Differential display identification of 40 genes with altered expression in activated human smooth muscle cells. Local expression in atherosclerotic lesions of smags, smooth muscle activation-specific genesQ28145016
The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRFQ28299203
TIF1beta/KAP-1 is a coactivator of the orphan nuclear receptor NGFI-B/Nur77Q28581440
Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1Q28591002
Interaction of the heart-specific LIM domain protein, FHL2, with DNA-binding nuclear protein, hNP220.Q31036529
Genome-scale loss-of-function screening with a lentiviral RNAi libraryQ33255059
Minireview: Nuclear hormone receptor 4A signaling: implications for metabolic disease.Q33637223
NR4A orphan nuclear receptors: transcriptional regulators of gene expression in metabolism and vascular biologyQ34007734
The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitmentQ34135086
CR6-interacting factor 1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivationQ34354801
Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuliQ34427465
The multifunctional roles of the four-and-a-half-LIM only protein FHL2.Q34481193
Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responsesQ34551946
Identification of the DNA binding site for NGFI-B by genetic selection in yeastQ34955524
The NR4A subfamily of nuclear receptors: new early genes regulated by growth factors in vascular cells.Q36017199
NR4A nuclear receptors in atherosclerosis and vein-graft diseaseQ36785354
NR4A nuclear orphan receptors: protective in vascular disease?Q36947980
Inflammation: a role for NR4A orphan nuclear receptors?Q37856432
TR3 nuclear orphan receptor prevents cyclic stretch-induced proliferation of venous smooth muscle cells.Q38623534
The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleusQ39646594
Synergistic repression of estrogen receptor transcriptional activity by FHL2 and Smad4 in breast cancer cellsQ39664035
Dimer-specific potentiation of NGFI-B (Nur77) transcriptional activity by the protein kinase A pathway and AF-1-dependent coactivator recruitmentQ39698781
Fhl2 interacts with Foxk1 and corepresses Foxo4 activity in myogenic progenitorsQ39762807
Titering lentiviral vectors: comparison of DNA, RNA and marker expression methodsQ40711680
TR3 orphan receptor is expressed in vascular endothelial cells and mediates cell cycle arrestQ42169040
Regulation of Nur77 protein turnover through acetylation and deacetylation induced by p300 and HDAC1.Q42827032
Four-and-a-half LIM domain protein 2 is a novel regulator of sphingosine 1-phosphate receptor 1 in CCL19-induced dendritic cell migration.Q42997708
The four-and-a-half LIM domain protein 2 regulates vascular smooth muscle phenotype and vascular toneQ43136778
Deletion of the FHL2 gene attenuates the formation of atherosclerotic lesions after a cholesterol-enriched dietQ43185780
Cardiac-specific LIM protein FHL2 modifies the hypertrophic response to beta-adrenergic stimulationQ43628829
Lentiviral vectors for efficient transduction of isolated primary quiescent hepatocytesQ43954074
Structural basis for the cell-specific activities of the NGFI-B and the Nurr1 ligand-binding domainQ45269797
NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolismQ46057176
Enhanced expression of FHL2 leads to abnormal myelopoiesis in vivoQ48000638
The orphan nuclear receptor Nur77 suppresses endothelial cell activation through induction of IkappaBalpha expression.Q51824215
Activation of nuclear receptor Nur77 by 6-mercaptopurine protects against neointima formation.Q53575755
Interaction of the heart-specific LIM domain protein, FHL2, with DNA-binding nuclear protein, hNP220Q56567512
Lentivirus Vectors Encoding Both Central Polypurine Tract and Posttranscriptional Regulatory Element Provide Enhanced Transduction and Transgene ExpressionQ61727540
Protective function of transcription factor TR3 orphan receptor in atherogenesis: decreased lesion formation in carotid artery ligation model in TR3 transgenic miceQ64378477
The NGFI-B subfamily of the nuclear receptor superfamily (review)Q74562999
Characterization of the Nurr1 ligand-binding domain co-activator interaction surfaceQ79219830
Oncogene functions of FHL2 are independent from NF-kappaBIalpha in gastrointestinal cancerQ81886839
Modulation of aryl hydrocarbon receptor activity by four and a half LIM domain 2Q82635079
P433issue52
P407language of work or nameEnglishQ1860
P1104number of pages8
P304page(s)44336-44343
P577publication date2011-11-02
P1433published inJournal of Biological ChemistryQ867727
P1476titleFHL2 protein is a novel co-repressor of nuclear receptor Nur77.
P478volume286

Reverse relations

cites work (P2860)
Q388628996-Mercaptopurine reduces cytokine and Muc5ac expression involving inhibition of NFκB activation in airway epithelial cells
Q49026148An emerging link between LIM domain proteins and nuclear receptors.
Q51608667Deficiency of FHL2 attenuates airway inflammation in mice and genetic variation associates with human bronchial hyper-responsiveness.
Q91588126Endothelial Colony Forming Cells as an Autologous Model to Study Endothelial Dysfunction in Patients with a Bicuspid Aortic Valve
Q37003274Epithelial expression of FHL2 is negatively associated with metastasis-free and overall survival in colorectal cancer
Q35772405FHL2 switches MITF from activator to repressor of Erbin expression during cardiac hypertrophy
Q38804262Four and a half LIM domains 2 contributes to the development of human tongue squamous cell carcinoma
Q92185461LIM-only protein FHL2 attenuates inflammation in vascular smooth muscle cells through inhibition of the NFκB pathway
Q34444310LIM-only protein FHL2 is a positive regulator of liver X receptors in smooth muscle cells involved in lipid homeostasis
Q40614757LIM-only protein FHL2 regulates experimental pulmonary Schistosoma mansoni egg granuloma formation
Q35942458Nur77-deficiency in bone marrow-derived macrophages modulates inflammatory responses, extracellular matrix homeostasis, phagocytosis and tolerance
Q58586821Orphan nuclear receptor TR3/Nur77 differentially regulates the expression of integrins in angiogenesis
Q34355852Repression of NR4A1 by a chromatin modifier promotes docetaxel resistance in PC-3 human prostate cancer cells
Q53676106TGF-β1-dependent induction and nuclear translocation of FHL2 promotes keratin expression in pilomatricoma.
Q34317218The LIM domain protein FHL2 interacts with the NR5A family of nuclear receptors and CREB to activate the inhibin-α subunit gene in ovarian granulosa cells
Q27339876The LIM-only protein FHL2 reduces vascular lesion formation involving inhibition of proliferation and migration of smooth muscle cells
Q37151504The four and a half LIM domains 2 (FHL2) regulates ovarian granulosa cell tumor progression via controlling AKT1 transcription

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