Oncogenic point mutations in the Myb DNA-binding domain alter the DNA-binding properties of Myb at a physiological target gene

scientific article published on 24 October 2007

Oncogenic point mutations in the Myb DNA-binding domain alter the DNA-binding properties of Myb at a physiological target gene is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/NAR/GKM675
P932PMC publication ID2175353
P698PubMed publication ID17959653
P5875ResearchGate publication ID5885512

P2093author name stringKarl-Heinz Klempnauer
Olga Ivanova
Daniel Braas
P2860cites workPoint mutations in v-Myb disrupt a cyclophilin-catalyzed negative regulatory mechanismQ24313422
Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoterQ27637335
Solution structure of a specific DNA complex of the Myb DNA-binding domain with cooperative recognition helicesQ27730748
The myb gene family in cell growth, differentiation and apoptosisQ28137891
The carbonic anhydrase I locus contains a c-Myb target promoter and modulates differentiation of murine erythroleukemia cellsQ30439216
Myb and oncogenesisQ33602232
Transformation by v-MybQ33667366
Identification and characterization of the protein encoded by the human c-myb proto-oncogene.Q33880208
Chromatin fine structure profiles for a developmentally regulated gene: reorganization of the lysozyme locus before trans-activator binding and gene expressionQ35201206
The v-myb oncogene product binds to and activates the promyelocyte-specific mim-1 geneQ35926914
trans activation of gene expression by v-mybQ36708907
Mutations in the DNA-binding and transcriptional activation domains of v-Myb cooperate in transformation.Q38296959
Synergistic activation of the chicken mim-1 gene by v-myb and C/EBP transcription factors.Q38319512
Oncogenic mutations cause dramatic, qualitative changes in the transcriptional activity of c-MybQ38320282
Specific DNA binding by c-Myb: evidence for a double helix-turn-helix-related motifQ38333441
A functional c-myb gene is required for normal murine fetal hepatic hematopoiesisQ38335144
Modular structure of a chicken lysozyme silencer: involvement of an unusual thyroid hormone receptor binding siteQ38340913
Characterization of the v-myb DNA binding domainQ38341266
Distinct changes in gene expression induced by A-Myb, B-Myb and c-Myb proteinsQ38358724
Developmentally regulated recruitment of transcription factors and chromatin modification activities to chicken lysozyme cis-regulatory elements in vivoQ39756594
Differentiation-dependent alterations in histone methylation and chromatin architecture at the inducible chicken lysozyme gene.Q40415780
v-Myb mediates cooperation of a cell-specific enhancer with the mim-1 promoter.Q40480344
Identification of a Myb-responsive enhancer of the chicken C/EBPbeta geneQ40545799
Lysozyme gene activity in chicken macrophages is controlled by positive and negative regulatory elementsQ40566953
Synergism in transcriptional activation: a kinetic viewQ40878139
Differential activity of the -2.7 kb chicken lysozyme enhancer in macrophages of different ontogenic origins is regulated by C/EBP and PU.1 transcription factors.Q40933229
Estrogen-dependent alterations in differentiation state of myeloid cells caused by a v-myb/estrogen receptor fusion proteinQ41083309
The highly conserved amino-terminal region of the protein encoded by the v-myb oncogene functions as a DNA-binding domain.Q41332871
Characterization of a myeloid-specific enhancer of the chicken lysozyme gene. Major role for an Ets transcription factor-binding siteQ41455480
Myb and NF-M: combinatorial activators of myeloid genes in heterologous cell typesQ41558201
The chicken lysozyme locus as a paradigm for the complex developmental regulation of eukaryotic gene loci.Q41614184
Myb proteins in life, death and differentiationQ41732749
Histone H3 tail positioning and acetylation by the c-Myb but not the v-Myb DNA-binding SANT domainQ41824791
tom-1, a novel v-Myb target gene expressed in AMV- and E26-transformed myelomonocytic cellsQ42274592
Activation of transcription by v-myb: evidence for two different mechanismsQ43498591
Mutations in v-myb alter the differentiation of myelomonocytic cells transformed by the oncogene.Q44606582
The product of the retroviral transforming gene v-myb is a truncated version of the protein encoded by the cellular oncogene c-mybQ45012365
Oncogenic point mutations induce altered conformation, redox sensitivity, and DNA binding in the minimal DNA binding domain of avian myeloblastosis virus v-MybQ45764914
Transcriptional activation by the v-myb oncogene and its cellular progenitor, c-mybQ46044395
Viral myb oncogene encodes a sequence-specific DNA-binding activity.Q46760013
The v-Myb oncoprotein activates C/EBPbeta expression by stimulating an autoregulatory loop at the C/EBPbeta promoterQ47915812
Xenopus A-myb is expressed during early spermatogenesisQ48111509
Alternative sets of DNase I-hypersensitive sites characterize the various functional states of the chicken lysozyme geneQ59092573
Myb proteins regulate the expression of diverse target genesQ81168211
P433issue21
P407language of work or nameEnglishQ1860
P304page(s)7237-7247
P577publication date2007-10-24
P1433published inNucleic Acids ResearchQ135122
P1476titleOncogenic point mutations in the Myb DNA-binding domain alter the DNA-binding properties of Myb at a physiological target gene
P478volume35

Reverse relations

cites work (P2860)
Q39715693A SUMO-regulated activation function controls synergy of c-Myb through a repressor-activator switch leading to differential p300 recruitment
Q36615988Demethylation of c-MYB binding site mediates upregulation of Bdnf IV in cocaine-conditioned place preference
Q39460430Inhibition of Myb-dependent gene expression by the sesquiterpene lactone mexicanin-I.
Q39785669Myb-induced chromatin remodeling at a dual enhancer/promoter element involves non-coding rna transcription and is disrupted by oncogenic mutations of v-myb

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