Hyperactive TGF-β Signaling in Smooth Muscle Cells Exposed to HIV-protein(s) and Cocaine: Role in Pulmonary Vasculopathy

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Hyperactive TGF-β Signaling in Smooth Muscle Cells Exposed to HIV-protein(s) and Cocaine: Role in Pulmonary Vasculopathy is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1091449545
P356DOI10.1038/S41598-017-10438-3
P932PMC publication ID5585314
P698PubMed publication ID28874783

P2093author name stringMiles Sanderson
Navneet K Dhillon
Pranjali Dalvi
Himanshu Sharma
Amy O' Brien-Ladner
Tomara Konstantinova
P2860cites workBMP type II receptor deficiency confers resistance to growth inhibition by TGF-β in pulmonary artery smooth muscle cells: role of proinflammatory cytokinesQ42570141
Echocardiographic abnormalities and associated factors in a cohort of asymptomatic HIV-infected patientsQ43720449
Cardiovascular diseases and HIV infection: study of 79 cases at the National Hospital of Ouagadougou (Burkina Faso)Q43934494
Inhibition of overactive transforming growth factor-β signaling by prostacyclin analogs in pulmonary arterial hypertensionQ43949318
Prognostic factors for survival in human immunodeficiency virus-associated pulmonary arterial hypertensionQ44342075
High prevalence of pulmonary arterial hypertension in a cohort of asymptomatic HIV-infected patients.Q45842543
BMPR2 gene delivery reduces mutation-related PAH and counteracts TGF-β-mediated pulmonary cell signallingQ45881763
Prevalence and risk factors associated with pulmonary hypertension in HIV-infected patients on regular follow-up.Q47865938
Effect of gender and highly active antiretroviral therapy on HIV-related pulmonary arterial hypertension: results of the HIV-HEART Study.Q51698325
BMPR-II deficiency elicits pro-proliferative and anti-apoptotic responses through the activation of TGFβ-TAK1-MAPK pathways in PAHQ57148790
Natural history of HIV-associated pulmonary arterial hypertension: trends in the HAART eraQ82254768
HIV-1/cocaine induced oxidative stress disrupts tight junction protein-1 in human pulmonary microvascular endothelial cells: role of Ras/ERK1/2 pathwayQ28538396
Non-Smad pathways in TGF-beta signalingQ29620040
MEKK1-MKK4-JNK-AP1 pathway negatively regulates Rgs4 expression in colonic smooth muscle cellsQ34251193
Effect of cocaine on human immunodeficiency virus-mediated pulmonary endothelial and smooth muscle dysfunctionQ35132178
HIV-Associated Pulmonary Hypertension: Diagnosis and TreatmentQ35553982
Prognosis of pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelinesQ35834000
Enhanced pulmonary arteriopathy in simian immunodeficiency virus-infected macaques exposed to morphineQ36026281
Ligand-Independent Activation of Platelet-Derived Growth Factor Receptor β during Human Immunodeficiency Virus-Transactivator of Transcription and Cocaine-Mediated Smooth Muscle HyperplasiaQ36049297
Pulmonary hypertension due to BMPR2 mutation: a new paradigm for tissue remodeling?Q36634716
Endothelial cell dysfunction and cross talk between endothelium and smooth muscle cells in pulmonary arterial hypertension.Q37209074
Role of HIV and human herpesvirus-8 infection in pulmonary arterial hypertensionQ37262847
Transforming growth factor-β(1) represses bone morphogenetic protein-mediated Smad signaling in pulmonary artery smooth muscle cells via Smad3Q37596473
BMPR2 gene therapy for PAH acts via Smad and non-Smad signalling.Q38799538
BMP9/p38 MAPK is essential for the antiproliferative effect of resveratrol on human colon cancerQ38820464
Novel p38 MAPK inhibitor ML3403 has potent anti-inflammatory activity in airway smooth muscleQ39728331
GDF5 and BMP2 inhibit apoptosis via activation of BMPR2 and subsequent stabilization of XIAP.Q39795043
Effect of Cocaine on Pulmonary Vascular Remodeling and Hemodynamics in Human Immunodeficiency Virus-Transgenic RatsQ40945385
Cellular and molecular mechanisms in the pathogenesis of severe pulmonary hypertensionQ41006494
Pulmonary hypertension in HIV infection: a prospective echocardiographic studyQ41243531
Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M.Q42012743
Downregulation of bone morphogenetic protein receptor axis during HIV-1 and cocaine-mediated pulmonary smooth muscle hyperplasia: implications for HIV-related pulmonary arterial hypertensionQ42134956
Echocardiographic screening for pulmonary arterial hypertension in HIV-positive patientsQ42232149
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)10433
P577publication date2017-09-05
P1433published inScientific ReportsQ2261792
P1476titleHyperactive TGF-β Signaling in Smooth Muscle Cells Exposed to HIV-protein(s) and Cocaine: Role in Pulmonary Vasculopathy
P478volume7

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cites work (P2860)
Q92035395Analysis of lncRNA-miRNA-mRNA Interactions in Hyper-proliferative Human Pulmonary Arterial Smooth Muscle Cells
Q90483681Chalcone flavokawain A attenuates TGF-β1-induced fibrotic pathology via inhibition of ROS/Smad3 signaling pathways and induction of Nrf2/ARE-mediated antioxidant genes in vascular smooth muscle cells
Q91573974Drug abuse and HIV-related pulmonary hypertension: double hit injury
Q52686168Network of MicroRNAs Mediate Translational Repression of Bone Morphogenetic Protein Receptor-2: Involvement in HIV-Associated Pulmonary Vascular Remodeling.

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