Aliskiren improves endothelium-dependent relaxation of thoracic aorta by activating PI3K/Akt/eNOS signal pathway in SHR.

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Aliskiren improves endothelium-dependent relaxation of thoracic aorta by activating PI3K/Akt/eNOS signal pathway in SHR. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/1440-1681.12550
P8608Fatcat IDrelease_tmxaa4wz4vdotaulj7cn2sw47y
P698PubMed publication ID26804705

P2093author name stringLiping Xie
Xin Tang
Yong Ji
Yue Gu
Guoliang Meng
P2860cites workAngiotensin II suppression in humans by the orally active renin inhibitor Aliskiren (SPP100): comparison with enalaprilQ28215905
Endothelial nitric oxide synthase in vascular disease: from marvel to menaceQ28305279
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Oxidative stress as a regulator of gene expression in the vasculatureQ33751805
Aliskiren - an alternative to angiotensin-converting enzyme inhibitors or angiotensin receptor blockers in the therapy of arterial hypertensionQ34247173
Inflammatory monocytes determine endothelial nitric-oxide synthase uncoupling and nitro-oxidative stress induced by angiotensin IIQ34283413
Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor toneQ34378188
Aliskiren attenuates steatohepatitis and increases turnover of hepatic fat in mice fed with a methionine and choline deficient dietQ35035662
Endothelial function testing as a biomarker of vascular diseaseQ35569232
Nitric oxide, an iceberg in cardiovascular physiology: far beyond vessel tone controlQ35704375
Effect of aliskiren on vascular remodelling in small retinal circulationQ35785397
Reactive oxygen species and angiotensin II signaling in vascular cells -- implications in cardiovascular diseaseQ35845567
cGMP-AMP synthase paves the way to autoimmunityQ36207307
Hypertension pharmacogenomics: in search of personalized treatment approachesQ36652960
Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanismsQ36726069
Direct renin inhibition with aliskiren protects against myocardial ischemia/reperfusion injury by activating nitric oxide synthase signaling in spontaneously hypertensive rats.Q37648622
Endothelial dysfunction in experimental models of arterial hypertension: cause or consequence?Q37677152
Direct renin inhibition: from pharmacological innovation to novel therapeutic opportunitiesQ37939271
Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: possible therapeutic targets?Q38122012
Nitric oxide and reactive oxygen species in limb vascular function: what is the effect of physical activity?Q38130310
New paradigms in inflammatory signaling in vascular endothelial cellsQ38166953
Vascular oxidative stress, nitric oxide and atherosclerosisQ38253137
Endothelium-derived Relaxing Factors of Small Resistance Arteries in HypertensionQ38262506
Renin inhibition and AT(1)R blockade improve metabolic signaling, oxidant stress and myocardial tissue remodeling.Q40262966
A Novel Arginase Inhibitor Derived from Scutellavia indica Restored Endothelial Function in ApoE-Null Mice Fed a High-Cholesterol Diet.Q41057570
Folic Acid Promotes Recycling of Tetrahydrobiopterin and Protects Against Hypoxia-Induced Pulmonary Hypertension by Recoupling Endothelial Nitric Oxide SynthaseQ41866231
The renin inhibitor aliskiren upregulates pro-angiogenic cells and reduces atherogenesis in miceQ42881647
Beneficial cardiac effects of the renin inhibitor aliskiren in spontaneously hypertensive ratsQ42972308
Aliskiren prevents cardiovascular complications and pancreatic injury in a mouse model of obesity and type 2 diabetesQ43247372
Protective effects of aliskiren on ischemia-reperfusion-induced renal injury in ratsQ43679068
Blood pressure lowering in essential hypertension with an oral renin inhibitor, aliskirenQ44642058
PPARalpha ligands activate antioxidant enzymes and suppress hepatic fibrosis in ratsQ45098411
Aliskiren enhances the protective effects of valsartan against cardiovascular and renal injury in endothelial nitric oxide synthase-deficient mice.Q45930091
Comparative effects of Aliskiren and Telmisartan in high fructose diet-induced metabolic syndrome in rats.Q46171351
Renin inhibitor aliskiren improves impaired nitric oxide bioavailability and protects against atherosclerotic changesQ46470676
Renin inhibition by aliskiren prevents atherosclerosis progression: comparison with irbesartan, atenolol, and amlodipineQ46662652
Direct renin inhibition with aliskiren improves ischemia-induced neovascularization: blood pressure-independent effectQ46681423
AMPKalpha1 regulates the antioxidant status of vascular endothelial cellsQ47801068
Long-term effect of molsidomine, a direct nitric oxide donor, as an add-on treatment, on endothelial dysfunction in patients with stable angina pectoris undergoing percutaneous coronary intervention: results of the MEDCOR trial.Q53542153
Combined Aliskiren and L-arginine treatment reverses renovascular hypertension in an animal model.Q53594610
Reversal of endothelial nitric oxide synthase uncoupling and up-regulation of endothelial nitric oxide synthase expression lowers blood pressure in hypertensive rats.Q54084809
Handle region peptide counteracts the beneficial effects of the Renin inhibitor aliskiren in spontaneously hypertensive rats.Q54387733
The direct renin inhibitor aliskiren improves vascular remodelling in transgenic rats harbouring human renin and angiotensinogen genesQ56985191
P433issue4
P921main subjectaortaQ101004
endotheliumQ111140
P304page(s)450-458
P577publication date2016-01-25
P1433published inClinical and Experimental Pharmacology and PhysiologyQ5133807
P1476titleAliskiren improves endothelium-dependent relaxation of thoracic aorta by activating PI3K/Akt/eNOS signal pathway in SHR.
P478volume43

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cites work (P2860)
Q92240832A Systems Pharmacology-Based Study of the Molecular Mechanisms of San Cao Decoction for Treating Hypertension
Q47369456Aliskiren protects against myocardial ischaemia-reperfusion injury via an endothelial nitric oxide synthase dependent manner
Q52632661Combined Antihypertensive Effect of Paeoniflorin Enriched Extract and Metoprolol in Spontaneously Hypertensive Rats.
Q89619897Kang Le Xin Reduces Blood Pressure Through Inducing Endothelial-Dependent Vasodilation by Activating the AMPK-eNOS Pathway
Q93047857MicroRNA-668-3p Protects Against Oxygen-Glucose Deprivation in a Rat H9c2 Cardiomyocyte Model of Ischemia-Reperfusion Injury by Targeting the Stromal Cell-Derived Factor-1 (SDF-1)/CXCR4 Signaling Pathway
Q92210228Protective Effects of Nanoparticle-Loaded Aliskiren on Cardiovascular System in Spontaneously Hypertensive Rats
Q33677627Salvia fruticosa Induces Vasorelaxation In Rat Isolated Thoracic Aorta: Role of the PI3K/Akt/eNOS/NO/cGMP Signaling Pathway.
Q91123985Sildenafil reduces aortic endothelial dysfunction and structural damage in spontaneously hypertensive rats: Role of NO, NADPH and COX-1 pathways
Q39198264The potential of stimulating nitric oxide formation in the treatment of hypertension

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