p19ARF is a critical mediator of both cellular senescence and an innate immune response associated with MYC inactivation in mouse model of acute leukemia

scientific article

p19ARF is a critical mediator of both cellular senescence and an innate immune response associated with MYC inactivation in mouse model of acute leukemia is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.2969
P932PMC publication ID4414137
P698PubMed publication ID25784651
P5875ResearchGate publication ID273784813

P50authorSylvia PlevritisQ89453368
Jan van RiggelenQ84411286
P2093author name stringArvin M Gouw
Dean W Felsher
Tahera Zabuawala
Stacey J Adam
Ramya Parameswaran
Alper Yetil
Benedict Anchang
P2860cites workBmi-1 is required for maintenance of adult self-renewing haematopoietic stem cellsQ28201183
Tumor suppression by Ink4a-Arf: progress and puzzlesQ28207959
ARF functions as a melanoma tumor suppressor by inducing p53-independent senescenceQ28591778
Cancer. Addiction to oncogenes--the Achilles heal of cancerQ29614243
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARFQ29619663
Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitorsQ33328820
Sumoylation induced by the Arf tumor suppressor: a p53-independent functionQ33821331
Reversible tumorigenesis by MYC in hematopoietic lineagesQ33874286
Differential effects of p19(Arf) and p16(Ink4a) loss on senescence of murine bone marrow-derived preB cells and macrophagesQ33933240
Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressorQ33961286
MYC Inactivation Elicits Oncogene Addiction through Both Tumor Cell-Intrinsic and Host-Dependent MechanismsQ34248882
Regulation of cellular senescence by p53.Q34254621
CD4+ T Cells Contribute to the Remodeling of the Microenvironment Required for Sustained Tumor Regression upon Oncogene InactivationQ34346803
Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanismQ34490491
Loss of p53 impedes the antileukemic response to BCR-ABL inhibitionQ34585293
Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch.Q35133764
Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesisQ35208288
INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.Q35208402
Lymphomas that recur after MYC suppression continue to exhibit oncogene addictionQ35409292
Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivationQ35928960
Tumor escape in a Wnt1-dependent mouse breast cancer model is enabled by p19Arf/p53 pathway lesions but not p16 Ink4a lossQ36183595
p53-Dependent and -independent functions of the Arf tumor suppressorQ36547718
ARF represses androgen receptor transactivation in prostate cancerQ36714871
RasV12-mediated down-regulation of CCAAT/enhancer binding protein beta in immortalized fibroblasts requires loss of p19Arf and facilitates bypass of oncogene-induced senescenceQ37219345
Tumor dormancy and oncogene addictionQ37286246
Differential effects on ARF stability by normal versus oncogenic levels of c-Myc expressionQ37344073
Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia.Q37351577
Tumor suppression by ARF: gatekeeper and caretakerQ37656961
The ARF tumor suppressor: structure, functions and status in cancerQ37765233
Pro-senescence therapy for cancer treatmentQ37893959
The Myc/macrophage tango: oncogene-induced senescence, Myc styleQ37948501
p19Arf inhibits the invasion of hepatocellular carcinoma cells by binding to C-terminal binding proteinQ38287966
RNA helicase DDX5 is a p53-independent target of ARF that participates in ribosome biogenesis.Q38906649
Arf tumor suppressor disrupts the oncogenic positive feedback loop including c-Myc and DDX5.Q39030003
The Arf tumor suppressor protein inhibits Miz1 to suppress cell adhesion and induce apoptosisQ39785267
C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cellsQ39954044
p14ARF directly interacts with Myc through the Myc BoxII domainQ40330377
Long-term outcome in children with relapsed ALL by risk-stratified salvage therapy: results of trial acute lymphoblastic leukemia-relapse study of the Berlin-Frankfurt-Münster Group 87.Q40376592
p19ARF directly and differentially controls the functions of c-Myc independently of p53.Q40516548
Myc-ARF (alternate reading frame) interaction inhibits the functions of Myc.Q40544963
The tumor suppressor ARF regulates innate immune responses in miceQ42497602
Expression of the p14ARF tumor suppressor predicts survival in acute myeloid leukemia.Q51028662
Genomic alterations of the p19ARF encoding exons in T-cell acute lymphoblastic leukemia.Q52528881
Aberrant methylation of p14ARF gene correlates with poor survival in osteosarcoma.Q54623978
Deregulation of c-myc by translocation of the alpha-locus of the T-cell receptor in T-cell leukemiasQ68797680
A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapyQ74117541
Sustained loss of a neoplastic phenotype by brief inactivation of MYCQ74413944
Genomically complex lymphomas undergo sustained tumor regression upon MYC inactivation unless they acquire novel chromosomal translocationsQ78762284
p14ARF protein expression is a predictor of both relapse and survival in squamous cell carcinoma of the anterior tongueQ81805963
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectcellular senescenceQ9075999
P304page(s)3563-3577
P577publication date2015-02-01
P1433published inOncotargetQ1573155
P1476titlep19ARF is a critical mediator of both cellular senescence and an innate immune response associated with MYC inactivation in mouse model of acute leukemia
P478volume6

Reverse relations

cites work (P2860)
Q42061306ARF: connecting senescence and innate immunity for clearance
Q47129670DNMT3B overexpression contributes to aberrant DNA methylation and MYC-driven tumor maintenance in T-ALL and Burkitt's lymphoma
Q40216791Globule Leukocytes and Other Mast Cells in the Mouse Intestine
Q39231572Menin Plays a Critical Role in the Regulation of the Antigen-Specific CD8+ T Cell Response upon Listeria Infection.
Q52728139The MYC oncogene is a global regulator of the immune response.
Q37687082Tumor suppressor ARF regulates tissue microenvironment and tumor growth through modulation of macrophage polarization.

Search more.