Menin-mediated caspase 8 expression in suppressing multiple endocrine neoplasia type 1.

scientific article published on 31 August 2007

Menin-mediated caspase 8 expression in suppressing multiple endocrine neoplasia type 1. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M609555200
P932PMC publication ID2858561
P698PubMed publication ID17766243

P2093author name stringXianxin Hua
Yuqing Yang
Robert W Schnepp
Seung K Kim
Ping La
Satyajit K Karnik
Albert C Silva
P2860cites workGenome-wide analysis of menin binding provides insights into MEN1 tumorigenesisQ21145267
Aggressive childhood neuroblastomas do not express caspase-8: an important component of programmed cell deathQ34340920
Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunityQ35964742
Multiple endocrine neoplasia--introductionQ35987830
Complexes containing the retinoblastoma gene product recognize different DNA motifs related to the E2F binding site.Q38328373
Reconstituted expression of menin in Men1-deficient mouse Leydig tumour cells induces cell cycle arrest and apoptosisQ40191217
Tumor suppressor menin: the essential role of nuclear localization signal domains in coordinating gene expressionQ40322558
The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesisQ40359760
Silencing of death receptor and caspase-8 expression in small cell lung carcinoma cell lines and tumors by DNA methylation.Q40654530
High-efficiency gene transfer and selection of human hematopoietic progenitor cells with a hybrid EBV/retroviral vector expressing the green fluorescence proteinQ41072145
The multiple endocrine neoplasia type 1 gene product, menin, inhibits insulin production in rat insulinoma cellsQ44000669
Histone deacetylase is a target of valproic acid-mediated cellular differentiationQ44761814
Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.Q52531761
Genetic ablation of the tumor suppressor menin causes lethality at mid-gestation with defects in multiple organs.Q52550786
Loss of caspase-8 expression in neuroblastoma is related to malignancy and resistance to TRAIL-induced apoptosis.Q54027482
Absent or reduced expression of the caspase 8 gene occurs frequently in neuroblastoma, but not commonly in Ewing sarcoma or rhabdomyosarcomaQ73271508
Heterozygous Men1 mutant mice develop a range of endocrine tumors mimicking multiple endocrine neoplasia type 1Q73557853
Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCNQ73766132
Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosisQ74256185
Menin, a tumor suppressor, represses JunD-mediated transcriptional activity by association with an mSin3A-histone deacetylase complexQ79166838
Menin links estrogen receptor activation to histone H3K4 trimethylationQ83228702
Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcriptionQ22001458
Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signalingQ24290996
The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivationQ24291618
Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expressionQ24297027
Direct binding of DNA by tumor suppressor meninQ24301985
Multiple tumor suppressor pathways negatively regulate telomeraseQ24306608
Menin, the product of the MEN1 gene, is a nuclear proteinQ24310070
Menin associates with FANCD2, a protein involved in repair of DNA damageQ24310300
Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locusQ24313196
Menin localizes to chromatin through an ATR-CHK1 mediated pathway after UV-induced DNA damageQ24337033
Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitorsQ24337658
The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expressionQ24536084
Synergistic cooperation of TFE3 and smad proteins in TGF-beta-induced transcription of the plasminogen activator inhibitor-1 geneQ24596458
Direct DNA binding by Brca1Q24629687
TNF-R1 signaling: a beautiful pathwayQ28201944
Identification of the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1Q28243243
Human Smad3 and Smad4 are sequence-specific transcription activatorsQ28276193
Functional interaction between tumor suppressor menin and activator of S-phase kinaseQ28282766
Positional cloning of the gene for multiple endocrine neoplasia-type 1Q28307577
Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4cQ28506197
Tumor suppressor menin regulates expression of insulin-like growth factor binding protein 2Q28506714
Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in miceQ28507607
Mutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cellsQ28587542
Menin induces apoptosis in murine embryonic fibroblastsQ28589504
Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissuesQ28589655
A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumorsQ28592210
Menin represses JunD-activated transcription by a histone deacetylase-dependent mechanismQ30779195
Multiple endocrine neoplasia type 1.Q33871564
Caspase-8 in apoptosis: the beginning of "the end"?Q34143631
The diverse functions of histone acetyltransferase complexes.Q34205129
P433issue43
P407language of work or nameEnglishQ1860
P921main subjectmultiple endocrine neoplasiaQ1553018
P304page(s)31332-31340
P577publication date2007-08-31
P1433published inJournal of Biological ChemistryQ867727
P1476titleMenin-mediated caspase 8 expression in suppressing multiple endocrine neoplasia type 1.
P478volume282

Reverse relations

cites work (P2860)
Q35942505A simple matter of life and death-the trials of postnatal Beta-cell mass regulation
Q49957735Current and emerging therapies for PNETs in patients with or without MEN1.
Q33402990Decreased expression and promoter methylation of the menin tumor suppressor in pancreatic ductal adenocarcinoma.
Q42324428Expression and subcellular localization of menin in human cancer cells
Q37022247Loss of MEN1 activates DNMT1 implicating DNA hypermethylation as a driver of MEN1 tumorigenesis
Q30558844MEN1 gene replacement therapy reduces proliferation rates in a mouse model of pituitary adenomas
Q61449013Menin Upregulates FOXO1 Protein Stability by Repressing Skp2-Mediated Degradation in β Cells
Q33566813Menin mediates Tat-induced neuronal apoptosis in brain frontal cortex of SIV-infected macaques and in Tat-treated cells
Q35376284Menin represses tumorigenesis via repressing cell proliferation
Q28296266Multiple endocrine neoplasia type 1 (MEN1) and type 4 (MEN4)
Q37630910Multiple endocrine neoplasia type 1 (MEN1): not only inherited endocrine tumors
Q35661980Proliferation rates of multiple endocrine neoplasia type 1 (MEN1)-associated tumors
Q33897734Regulation of cyclin B2 expression and cell cycle G2/m transition by menin
Q64996730Ribozyme-mediated compensatory induction of menin-oncosuppressor function in primary fibroblasts from MEN1 patients.
Q91322283Tissue-specific induced DNA methyltransferase 1 (Dnmt1) in endocrine pancreas by RCAS-TVA-based somatic gene transfer system promotes β-cell proliferation