Human matrix metalloproteinase-8 gene delivery increases the oncolytic activity of a replicating adenovirus.

scientific article

Human matrix metalloproteinase-8 gene delivery increases the oncolytic activity of a replicating adenovirus. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SJ.MT.6300264
P698PubMed publication ID17653103
P5875ResearchGate publication ID6185908

P50authorJohn G HayQ55267033
Harald SauthoffQ55267036
P2093author name stringDavid I Kutler
William N Rom
Sofia Bajwa
Jin Cheng
YaoQi Huang
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Altered metastatic behavior of human breast cancer cells after experimental manipulation of matrix metalloproteinase 8 gene expressionQ40583196
Intratumoral spread of wild-type adenovirus is limited after local injection of human xenograft tumors: virus persists and spreads systemically at late time pointsQ40656148
Expression of matrix metalloproteinase 8 (MMP-8) and tyrosinase-related protein-1 (TYRP-1) correlates with the absence of metastasis in an isogenic human breast cancer modelQ40663418
Deletion of the adenoviral E1b-19kD gene enhances tumor cell killing of a replicating adenoviral vectorQ40897014
A phase I open-label, dose-escalation, multi-institutional trial of injection with an E1B-Attenuated adenovirus, ONYX-015, into the peritumoral region of recurrent malignant gliomas, in the adjuvant setting.Q42639115
Loss of collagenase-2 confers increased skin tumor susceptibility to male mice.Q44601270
Treatment with human metalloproteinase-8 gene delivery ameliorates experimental rat liver cirrhosis.Q44825219
Cirrhotic rat livers with extensive fibrosis can be safely transduced with clinical-grade adenoviral vectors. Evidence of cirrhosis reversionQ45158832
Pretreatment with protease is a useful experimental strategy for enhancing adenovirus-mediated cancer gene therapyQ45180665
Pharmacokinetics of oncolytic measles virotherapy: eventual equilibrium between virus and tumor in an ovarian cancer xenograft modelQ45418761
Relaxin expression from tumor-targeting adenoviruses and its intratumoral spread, apoptosis induction, and efficacyQ45863191
Phase I-II trial of ONYX-015 in combination with MAP chemotherapy in patients with advanced sarcomasQ45880512
Hypoxia reduces adenoviral replication in cancer cells by downregulation of viral protein expressionQ45881054
Membrane-bound matrix metalloproteinase-8 on activated polymorphonuclear cells is a potent, tissue inhibitor of metalloproteinase-resistant collagenase and serpinaseQ47371084
Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammationQ47752298
Resistance of collagenase-2 (matrix metalloproteinase-8)-deficient mice to TNF-induced lethal hepatitisQ49099417
Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generationQ57662899
The end of the beginning: oncolytic virotherapy achieves clinical proof-of-conceptQ64378176
Wild-type adenovirus decreases tumor xenograft growth, but despite viral persistence complete tumor responses are rarely achieved--deletion of the viral E1b-19-kD gene increases the viral oncolytic effectQ64379701
Truncated active matrix metalloproteinase-8 gene expression in HepG2 cells is active against native type I collagenQ64380260
Expression of neutrophil collagenase (matrix metalloproteinase-8) in human atheroma: a novel collagenolytic pathway suggested by transcriptional profilingQ74623079
P433issue11
P921main subjectAdenoviridaeQ193447
oncolytic virusQ1560099
P304page(s)1982-1990
P577publication date2007-07-24
P1433published inMolecular TherapyQ15762400
P1476titleHuman matrix metalloproteinase-8 gene delivery increases the oncolytic activity of a replicating adenovirus
P478volume15

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