Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion

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Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1013221253
P356DOI10.1038/NCB1616
P698PubMed publication ID17618273
P5875ResearchGate publication ID6220217

P50authorChristopher OverallQ42843211
Sharon StackQ63651438
P2093author name stringPeter Friedl
Jörg Geiger
Eric Tam
Yi I Wu
Katarina Wolf
Yueying Liu
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Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysisQ29615193
Taking cell-matrix adhesions to the third dimensionQ29615214
Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysisQ29616712
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Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesivenessQ29620446
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Extracellular matrix 6: role of matrix metalloproteinases in tumor invasion and metastasis.Q40791456
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ECM regulates MT1-MMP localization with beta1 or alphavbeta3 integrins at distinct cell compartments modulating its internalization and activity on human endothelial cellsQ42175129
Cytoplasmic tail-dependent internalization of membrane-type 1 matrix metalloproteinase is important for its invasion-promoting activity.Q42952060
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Membrane-type 1 matrix metalloproteinase modulates focal adhesion stability and cell migrationQ46940704
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Collagen binding properties of the membrane type-1 matrix metalloproteinase (MT1-MMP) hemopexin C domain. The ectodomain of the 44-kDa autocatalytic product of MT1-MMP inhibits cell invasion by disrupting native type I collagen cleavageQ47848280
Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix.Q53923828
Matrix-dependent proteolysis of surface transglutaminase by membrane-type metalloproteinase regulates cancer cell adhesion and locomotion.Q55474490
MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnoverQ73082300
Kinetic analysis of the binding of human matrix metalloproteinase-2 and -9 to tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2Q73877082
Formation of extracellular matrix-digesting invadopodia by primary aortic smooth muscle cellsQ80187068
P433issue8
P921main subjectproteolysisQ33123
P304page(s)893-904
P577publication date2007-07-08
P1433published inNature Cell BiologyQ1574111
P1476titleMulti-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion
P478volume9

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Q35225370Metastasis Update: Human Prostate Carcinoma Invasion via Tubulogenesis.
Q83523452Metastasis suppressors and the tumor microenvironment
Q50025318MicroRNA-466 (miR-466) functions as a tumor suppressor and prognostic factor in colorectal cancer (CRC).
Q30537792Microfabricated collagen tracks facilitate single cell metastatic invasion in 3D
Q34856626Microfluidics-based devices: New tools for studying cancer and cancer stem cell migration
Q92542739Microscale Interrogation of 3D Tissue Mechanics
Q37100566Migratory neighbors and distant invaders: tumor-associated niche cells
Q47661828Mitosis-Mediated Intravasation in a Tissue-Engineered Tumor-Microvessel Platform
Q42073970Modeling and imaging 3-dimensional collective cell invasion
Q42045002Modeling colon adenocarcinomas in vitro a 3D co-culture system induces cancer-relevant pathways upon tumor cell and stromal fibroblast interaction
Q34558272Modeling extracellular matrix reorganization in 3D environments
Q36339995Modeling the Transitions between Collective and Solitary Migration Phenotypes in Cancer Metastasis
Q36917436Modeling the mechanics of cancer: effect of changes in cellular and extra-cellular mechanical properties
Q39085737Modes of invasion during tumour dissemination.
Q36796844Molecular dissection of the structural machinery underlying the tissue-invasive activity of membrane type-1 matrix metalloproteinase
Q33768557Motility-related actinin alpha-4 is associated with advanced and metastatic ovarian carcinoma
Q27312056Multi-cellular logistics of collective cell migration
Q64951524Multicompartment cell-based modeling of confined migration: regulation by cell intrinsic and extrinsic factors.
Q27313680Multiparametric classification links tumor microenvironments with tumor cell phenotype
Q30527787N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods
Q36010032N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors
Q36242789N-cadherin-mediated cell-cell adhesion promotes cell migration in a three-dimensional matrix
Q37977230Neural crest delamination and migration: from epithelium-to-mesenchyme transition to collective cell migration
Q37820192New Strategies for the Next Generation of Matrix-Metalloproteinase Inhibitors: Selectively Targeting Membrane-Anchored MMPs with Therapeutic Antibodies
Q58022449New dimensions in cell migration
Q37783808New insights into the dynamics of cell adhesions
Q34207052Non-muscle myosins in tumor progression, cancer cell invasion, and metastasis
Q46223612Nonlinear optical microscopy reveals invading endothelial cells anisotropically alter three-dimensional collagen matrices
Q34190659Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth
Q52687355Novel proteins that regulate cell extension formation in fibroblasts.
Q90708456Nuclear Mechanics and Cancer Cell Migration
Q39302311Nuclear deformation during breast cancer cell transmigration.
Q34777149Nuclear mechanics during cell migration.
Q36116300Nuclear mechanics in cancer
Q36144958Nuclear mechanics in disease
Q28070084Nuclear migration events throughout development
Q37183946Nuclear shape, mechanics, and mechanotransduction
Q46799501Nuclei migrate through constricted spaces using microtubule motors and actin networks in C. elegans hypodermal cells
Q38355587On the move: endocytic trafficking in cell migration.
Q38699073On-command on/off switching of progenitor cell and cancer cell polarized motility and aligned morphology via a cytocompatible shape memory polymer scaffold.
Q33922819Orientation and polarity in collectively migrating cell structures: statics and dynamics.
Q53425363Ovarian cancer-derived extracellular vesicles affect normal human fibroblast behavior.
Q37113828Ovarian cancer: involvement of the matrix metalloproteinases
Q37688629PAK4 suppresses PDZ-RhoGEF activity to drive invadopodia maturation in melanoma cells.
Q30739775Path to Collagenolysis: COLLAGEN V TRIPLE-HELIX MODEL BOUND PRODUCTIVELY AND IN ENCOUNTERS BY MATRIX METALLOPROTEINASE-12.
Q33753911Patterning N-type and S-type neuroblastoma cells with Pluronic F108 and ECM proteins
Q34430691Pericellular proteolysis in cancer
Q43140849Peter Friedl: Painting a picture of cancer immunology. Interview by Caitlin Sedwick
Q35588436Phosphoramidate-based peptidomimetic inhibitors of membrane type-1 matrix metalloproteinase
Q30435633Phthalimide neovascular factor 1 (PNF1) modulates MT1-MMP activity in human microvascular endothelial cells
Q27021875Physical biology in cancer. 5. The rocky road of metastasis: the role of cytoskeletal mechanics in cell migratory response to 3D matrix topography
Q38263780Physical influences of the extracellular environment on cell migration
Q30540882Physical limits of cell migration: control by ECM space and nuclear deformation and tuning by proteolysis and traction force
Q26801831Physical view on migration modes
Q37746085Physico-mechanical aspects of extracellular matrix influences on tumorigenic behaviors
Q92393013Phytochemicals inhibit migration of triple negative breast cancer cells by targeting kinase signaling
Q35095249Pigment epithelium-derived factor blocks tumor extravasation by suppressing amoeboid morphology and mesenchymal proteolysis.
Q38293612Pivotal role of pervasive neoplastic and stromal cells reprogramming in circulating tumor cells dissemination and metastatic colonization.
Q100745922Plasticity of cancer cell invasion: Patterns and mechanisms
Q29620332Plasticity of cell migration: a multiscale tuning model
Q38963431Plasticity of tumor cell invasion: governance by growth factors and cytokines.
Q33665623Pleiotropic roles of matrix metalloproteinases in tumor angiogenesis: contrasting, overlapping and compensatory functions
Q39913714Polarized MT1-MMP-CD44 interaction and CD44 cleavage during cell retraction reveal an essential role for MT1-MMP in CD44-mediated invasion.
Q42146832Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels
Q38830884Probing 3D Collective Cancer Invasion Using Double-Stranded Locked Nucleic Acid Biosensors
Q33615751Probing cell traction forces in confined microenvironments
Q35322761Probing the biophysical properties of primary breast tumor-derived fibroblasts
Q37310983Profiling distinct mechanisms of tumour invasion for drug discovery: imaging adhesion, signalling and matrix turnover
Q39756023Protease inhibitor SERPINA1 expression in epithelial ovarian cancer
Q34971595Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited
Q40067505Proteolysis of the membrane type-1 matrix metalloproteinase prodomain: implications for a two-step proteolytic processing and activation.
Q27300808Proteolytic and non-proteolytic regulation of collective cell invasion: tuning by ECM density and organization.
Q48209903Proximity of Metastatic Cells Enhances Their Mechanobiological Invasiveness.
Q38947755Quantification of Multicellular Organization, Junction Integrity, and Substrate Features in Collective Cell Migration
Q42826825Quantifying cell-induced matrix deformation in three dimensions based on imaging matrix fibers
Q34042876Quantitative analysis of the effect of cancer invasiveness and collagen concentration on 3D matrix remodeling
Q58786959Quantitative phase imaging unravels new insight into dynamics of mesenchymal and amoeboid cancer cell invasion
Q37582153Quantitative real-time imaging of molecular dynamics during cancer cell invasion and metastasis in vivo
Q34260423RAC1 activation mediates Twist1-induced cancer cell migration
Q50289278RETRACTED: FMN2 Makes Perinuclear Actin to Protect Nuclei during Confined Migration and Promote Metastasis
Q30838566Rac GTPase regulation of 3D invasion in neuroblastomas lacking MYCN amplification.
Q21245504Rac and Rho GTPases in cancer cell motility control
Q33686753Rapid prototyping of concave microwells for the formation of 3D multicellular cancer aggregates for drug screening.
Q37962657Real-time intravital imaging of cancer models
Q37351034Regulation of Epithelial-to-Mesenchymal Transition Using Biomimetic Fibrous Scaffolds
Q34268182Regulation of ROCK1 via Notch1 during breast cancer cell migration into dense matrices.
Q36693243Regulation of cell proliferation and migration in glioblastoma: new therapeutic approach
Q36463002Regulation of collective cell migration by RhoGAP myosin IXA
Q36978333Regulation of focal adhesion kinase activation, breast cancer cell motility, and amoeboid invasion by the RhoA guanine nucleotide exchange factor Net1.
Q36853200Regulation of invadopodia by mechanical signaling
Q60098457Research highlights
Q42595904Rheology and confocal reflectance microscopy as probes of mechanical properties and structure during collagen and collagen/hyaluronan self-assembly
Q27023656Rho GTPases in collective cell migration
Q26751189Rho, ROCK and actomyosin contractility in metastasis as drug targets
Q37540188Role of microRNA-mediated MMP regulation in the treatment and diagnosis of malignant tumors
Q30601534STIM1- and Orai1-mediated Ca(2+) oscillation orchestrates invadopodium formation and melanoma invasion
Q36190097Selective function-blocking monoclonal human antibody highlights the important role of membrane type-1 matrix metalloproteinase (MT1-MMP) in metastasis
Q37612398Shining new light on 3D cell motility and the metastatic process
Q37011994Signaling inputs to invadopodia and podosomes
Q30494198Significantly improved precision of cell migration analysis in time-lapse video microscopy through use of a fully automated tracking system
Q28834278Single-Cell Migration in Complex Microenvironments: Mechanics and Signaling Dynamics
Q38166254Small Rho GTPases in the control of cell shape and mobility
Q91143137Snail-induced claudin-11 prompts collective migration for tumour progression
Q37582531Soft matrix is a natural stimulator for cellular invasiveness
Q30498093Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53
Q37621087Subcutaneous preconditioning increases invasion and metastatic dissemination in mouse colorectal cancer models
Q33762943Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration.
Q33762066Synthesis of photodegradable hydrogels as dynamically tunable cell culture platforms
Q92984320Systems Biology of Cancer Metastasis
Q84742794TGF-beta helps cells fly solo
Q27330524TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion.
Q34292719Targeting melanoma metastasis and immunosuppression with a new mode of melanoma inhibitory activity (MIA) protein inhibition
Q34800574Targeting the Warburg effect that arises in tumor cells expressing membrane type-1 matrix metalloproteinase
Q38097602Targeting tumor cell motility as a strategy against invasion and metastasis
Q35095152Targeting tumor cell motility to prevent metastasis.
Q38118800Techniques for assessing 3-D cell-matrix mechanical interactions in vitro and in vivo
Q24614572The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function
Q30579952The Arp2/3 complex mediates multigeneration dendritic protrusions for efficient 3-dimensional cancer cell migration.
Q96304809The Emerging Roles of Heterochromatin in Cell Migration
Q92348350The Expanding Role of MT1-MMP in Cancer Progression
Q33838714The Functions of MicroRNA-200 Family in Ovarian Cancer: Beyond Epithelial-Mesenchymal Transition
Q38998765The Mechanics of Single Cell and Collective Migration of Tumor Cells
Q38815843The Role of Direct Current Electric Field-Guided Stem Cell Migration in Neural Regeneration
Q59128386The Role of Melanoma Cell-Stroma Interaction in Cell Motility, Invasion, and Metastasis
Q57816901The Role of the Extracellular Matrix and Its Molecular and Cellular Regulators in Cancer Cell Plasticity
Q24299587The Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: implications in cancer and embryogenesis.
Q37170851The actin cytoskeleton in cancer cell motility
Q24298597The actin-bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasion
Q37868444The biomechanical properties of 3d extracellular matrices and embedded cells regulate the invasiveness of cancer cells.
Q37867486The calpain system and cancer.
Q37046694The cancer-testis antigens SPANX-A/C/D and CTAG2 promote breast cancer invasion
Q38135403The cellular mechanics of an invasive lifestyle.
Q55176664The crosstalk between breast carcinoma-associated fibroblasts and cancer cells promotes RhoA-dependent invasion via IGF-1 and PAI-1.
Q27300118The development of a novel high throughput computational tool for studying individual and collective cellular migration
Q42223256The distinct roles of the nucleus and nucleus-cytoskeleton connections in three-dimensional cell migration
Q59134962The evolving relationship of wound healing and tumor stroma
Q38685677The front and rear of collective cell migration.
Q27003744The interplay between the proteolytic, invasive, and adhesive domains of invadopodia and their roles in cancer invasion
Q21710722The many roles of PTK7: A versatile regulator of cell–cell communication
Q37306467The mechanical rigidity of the extracellular matrix regulates the structure, motility, and proliferation of glioma cells.
Q38122126The pathobiology of collagens in glioma
Q21131317The regulation of MMP targeting to invadopodia during cancer metastasis
Q35556999The role of actin bundling proteins in the assembly of filopodia in epithelial cells
Q92589647The role of actin protrusion dynamics in cell migration through a degradable viscoelastic extracellular matrix: Insights from a computational model
Q41037827The role of extracellular matrix in glioma invasion: a cellular Potts model approach
Q92890916The role of polarisation of circulating tumour cells in cancer metastasis
Q37786017The role of the tissue microenvironment in the regulation of cancer cell motility and invasion.
Q38771942The role of tumor microenvironment in collective tumor cell invasion
Q34356018The sodium channel β1 subunit mediates outgrowth of neurite-like processes on breast cancer cells and promotes tumour growth and metastasis.
Q47772811The store-operated calcium channels in cancer metastasis: from cell migration, invasion to metastatic colonization
Q92688966The use of mixed collagen-Matrigel matrices of increasing complexity recapitulates the biphasic role of cell adhesion in cancer cell migration: ECM sensing, remodeling and forces at the leading edge of cancer invasion
Q37635053Three-dimensional collagen matrix induces a mechanosensitive invasive epithelial phenotype
Q39270254Three-dimensional invasion of macrophages is mediated by cysteine cathepsins in protrusive podosomes
Q37284912Toward plasmonics-enabled spatiotemporal activity patterns in three-dimensional culture models
Q42119647Trailblazing LIM kinases take the lead in collective tumor cell invasion
Q58704679Tumor cell density regulates matrix metalloproteinases for enhanced migration
Q28073065Tumor cell dormancy
Q27027489Tumor cell migration in complex microenvironments
Q39117565Tumor cohesion and glioblastoma cell dispersal
Q34614923Tumor growth in complex, evolving microenvironmental geometries: a diffuse domain approach
Q39425138Tumor microenvironment and noncoding RNAs as co-drivers of epithelial-mesenchymal transition and cancer metastasis.
Q41580419Tumour heterogeneity promotes collective invasion and cancer metastatic dissemination
Q37464162Tumour-suppressor microRNAs regulate ovarian cancer cell physical properties and invasive behaviour.
Q39092645Tuning Collective Cell Migration by Cell-Cell Junction Regulation.
Q34396542Up-regulation of stromal versican expression in advanced stage serous ovarian cancer
Q26786070Utilization of Glycosaminoglycans/Proteoglycans as Carriers for Targeted Therapy Delivery
Q38696893Vascular Mechanobiology: Towards Control of In Situ Regeneration.
Q39707748Velocity fields in a collectively migrating epithelium.
Q93076635What makes cells move: Requirements and obstacles for leader cells in collective invasion
Q53680625[Carcinoma-associated fibroblasts in cancer: the great escape].
Q38884681p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer.
Q41354391ΔNp63α induces the expression of FAT2 and Slug to promote tumor invasion

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