Macrophage inflammatory protein-1alpha (MIP-1alpha) enhances a receptor activator of nuclear factor kappaB ligand (RANKL) expression in mouse bone marrow stromal cells and osteoblasts through MAPK and PI3K/Akt pathways

scientific article published on 5 June 2007

Macrophage inflammatory protein-1alpha (MIP-1alpha) enhances a receptor activator of nuclear factor kappaB ligand (RANKL) expression in mouse bone marrow stromal cells and osteoblasts through MAPK and PI3K/Akt pathways is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S11010-007-9485-7
P698PubMed publication ID17549607

P2093author name stringTakao Satou
Masanobu Tsubaki
Shozo Nishida
Tatsuki Itoh
Hiroshi Matsuoka
Chisato Kato
Mitsuhiko Ogaki
Takashi Kusunoki
Yoshihiro Tanimori
Kimiko Fujiwara
Miyuki Manno
P2860cites workOsteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKLQ24682139
Macrophage inflammatory protein-1alpha is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor kappaB ligandQ30670375
A new member of tumor necrosis factor ligand family, ODF/OPGL/TRANCE/RANKL, regulates osteoclast differentiation and functionQ33542094
Multiple myeloma disrupts the TRANCE/ osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progressionQ33944735
Nitrogen-containing bisphosphonate, YM529/ONO-5920 (a novel minodronic acid), inhibits RANKL expression in a cultured bone marrow stromal cell line ST2.Q40465940
Parathyroid hormone stimulates receptor activator of NFkappa B ligand and inhibits osteoprotegerin expression via protein kinase A activation of cAMP-response element-binding proteinQ40699804
Intracellular calcium and protein kinase C mediate expression of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in osteoblastsQ40838654
Expression levels of gp130 in bone marrow stromal cells determine the magnitude of osteoclastogenic signals generated by IL-6-type cytokinesQ40853809
STAT3 activation in stromal/osteoblastic cells is required for induction of the receptor activator of NF-kappaB ligand and stimulation of osteoclastogenesis by gp130-utilizing cytokines or interleukin-1 but not 1,25-dihydroxyvitamin D3 or parathyroiQ40945774
Establishment and characterization of an immortal macrophage-like cell line inducible to differentiate to osteoclasts.Q41065416
p38 MAPK-mediated signals are required for inducing osteoclast differentiation but not for osteoclast functionQ44072080
Stimulation of osteoclast formation by 1,25-dihydroxyvitamin D requires its binding to vitamin D receptor (VDR) in osteoblastic cells: studies using VDR knockout mice.Q54106653
Role of receptor activator of nuclear factor-kappa B ligand (RANKL), osteoprotegerin and macrophage protein 1-alpha (MIP-1a) in monoclonal gammopathy of undetermined significance (MGUS)Q57904962
Osteoblasts/stromal cells stimulate osteoclast activation through expression of osteoclast differentiation factor/RANKL but not macrophage colony-stimulating factor: receptor activator of NF-kappa B ligandQ73211247
p44/42 MAPK activation is necessary for receptor activator of nuclear factor-kappaB ligand induction by high extracellular calciumQ73343165
Knockout of the murine prostaglandin EP2 receptor impairs osteoclastogenesis in vitroQ73832169
Role for macrophage inflammatory protein (MIP)-1alpha and MIP-1beta in the development of osteolytic lesions in multiple myelomaQ74676116
Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environmentQ77337113
Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myelomaQ77337118
MIP-1 gamma promotes receptor-activator-of-NF-kappa-B-ligand-induced osteoclast formation and survivalQ80363114
Annexin II stimulates RANKL expression through MAPKQ81820774
P433issue1-2
P407language of work or nameEnglishQ1860
P921main subjectosteoblastQ917177
P304page(s)53-60
P577publication date2007-06-05
P1433published inMolecular and Cellular BiochemistryQ1573176
P1476titleMacrophage inflammatory protein-1alpha (MIP-1alpha) enhances a receptor activator of nuclear factor kappaB ligand (RANKL) expression in mouse bone marrow stromal cells and osteoblasts through MAPK and PI3K/Akt pathways
P478volume304

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cites work (P2860)
Q38218256AKT as a therapeutic target in multiple myeloma
Q43378586Animal Models of Cancer-Associated Hypercalcemia
Q42027903Bisphosphonates and statins inhibit expression and secretion of MIP-1α via suppression of Ras/MEK/ERK/AML-1A and Ras/PI3K/Akt/AML-1A pathways
Q35603116Bone anabolic agents for the treatment of multiple myeloma
Q95840053CCL3-CCR5 axis contributes to progression of esophageal squamous cell carcinoma by promoting cell migration and invasion via Akt and ERK pathways
Q37879210CCR1 as a target for multiple myeloma
Q36177928CCR1 blockade reduces tumor burden and osteolysis in vivo in a mouse model of myeloma bone disease
Q90401357Chemokines in Physiological and Pathological Bone Remodeling
Q32874862DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice.
Q35857559Effects of parathyroid hormone-related protein and macrophage inflammatory protein-1α in Jurkat T-cells on tumor formation in vivo and expression of apoptosis regulatory genes in vitro
Q39192262Gene silencing of the BDNF/TrkB axis in multiple myeloma blocks bone destruction and tumor burden in vitro and in vivo
Q42330053Glucosamine and chondroitin for the treatment of osteoarthritis
Q44971021Hyperocclusion up-regulates CCL3 expression in CCL2- and CCR2-deficient mice
Q37310621Immunomodulatory and anti-inflammatory effects of chondroitin sulphate
Q42071261In vivo hypobaric hypoxia performed during the remodeling process accelerates bone healing in mice
Q34450321Inhibition of BDNF in multiple myeloma blocks osteoclastogenesis via down-regulated stroma-derived RANKL expression both in vitro and in vivo
Q42077222Inhibitory effects of ZSTK474, a novel phosphoinositide 3-kinase inhibitor, on osteoclasts and collagen-induced arthritis in mice
Q42068905Mangiferin suppresses CIA by suppressing the expression of TNF-α, IL-6, IL-1β, and RANKL through inhibiting the activation of NF-κB and ERK1/2.
Q37546949Mitogen-Activated Protein Kinase 2 Signaling Shapes Macrophage Plasticity in Aggregatibacter actinomycetemcomitans-Induced Bone Loss
Q35063276Mouse Rankl expression is regulated in T cells by c-Fos through a cluster of distal regulatory enhancers designated the T cell control region
Q57794000Myeloma Bone Disease: Update on Pathogenesis and Novel Treatment Strategies
Q34720969Osteoblast inhibition by chemokine cytokine ligand3 in myeloma-induced bone disease
Q39811943Potential enhancement of osteoclastogenesis by severe acute respiratory syndrome coronavirus 3a/X1 protein
Q42007201Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts
Q57021446RANKL-induced c-Src activation contributes to conventional anti-cancer drug resistance and dasatinib overcomes this resistance in RANK-expressing multiple myeloma cells
Q54976586Tanshinone IIA attenuates osteoclastogenesis in ovariectomized mice by inactivating NF-kB and Akt signaling pathways.
Q27024561Targeting tumor-stromal interactions in bone metastasis
Q53397945The Biological Activities of Oleocanthal from a Molecular Perspective.
Q47618731The MIP-1α autocrine loop contributes to decreased sensitivity to anticancer drugs
Q33607950The Role of PI3K Isoforms in Regulating Bone Marrow Microenvironment Signaling Focusing on Acute Myeloid Leukemia and Multiple Myeloma.
Q39196233The inhibitory effect of roasted licorice extract on human metastatic breast cancer cell-induced bone destruction.
Q38724068The macrophage inflammatory proteins MIP1α (CCL3) and MIP2α (CXCL2) in implant-associated osteomyelitis: linking inflammation to bone degradation

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