The GABA postsynaptic membrane receptor-ionophore complex. Site of action of convulsant and anticonvulsant drugs

scientific article published on September 1981

The GABA postsynaptic membrane receptor-ionophore complex. Site of action of convulsant and anticonvulsant drugs is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1007/BF00232579
P698PubMed publication ID6273709

P2093author name stringR W Olsen
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Chlordiazepoxide selectively augments GABA action in spinal cord cell culturesQ34236451
In vitro modulations by SQ 20009 and SQ 65396 of GABA receptor binding in rat CNS membranesQ34246002
(-)Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor.Q34251383
Barbiturate receptor sites are coupled to benzodiazepine receptorsQ34252358
Gamma-aminobutyric acid binding to receptor sites in the rat central nervous system.Q35119680
The glycine synaptic receptor: evidence that strychnine binding is associated with the ionic conductance mechanismQ35129045
Augmentation by chlordiazepoxide of the inhibitory effects of taurine, beta-alanine and gamma-aminobutyric acid on spike discharges in guinea-pig cerebellar slicesQ35178006
Benzodiazepine receptor protein identified and visualized in brain tissue by a photoaffinity labelQ36361313
Urinary and brain beta-carboline-3-carboxylates as potent inhibitors of brain benzodiazepine receptorsQ36365251
Effects of the bicyclic GABA agonist, THIP, on myoclonic and seizure responses in mice and baboons with reflex epilepsyQ71496995
Interaction of SQ 20009 and GABA-like drugs as modulators of benzodiazepine receptor bindingQ72135969
Solubilization and properties of a benzodiazepine receptor from calf cortexQ72430026
The effect of temperature and chloride ions on the stimulation of [3H]Flunitrazepam binding by the muscimol analogues THIP and piperidine-4-sulfonic acidQ72551797
A site for the potentiation of GABA-mediated responses by benzodiazepinesQ72847778
Molecular heterogeneity of benzodiazepine receptorsQ72859968
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Ethanol enhances [3H]diazepam binding at the benzodiazepine-GABA-receptor-ionophore complexQ72878941
Anion permeability of the synaptic and non-synaptic motoneurone membraneQ79335833
Diphenylhydantoin prolongs postsynaptic inhibition and iontophoretic GABA action in the crayfish stretch receptorQ84234801
Repeated seizures induce long-term increase in hippocampal benzodiazepine receptorsQ36391131
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Stimulation of benzodiazepine receptor binding by gamma-aminobutyric acidQ37317413
Inosine, an endogenous ligand of the brain benzodiazepine receptor, antagonizes pentylenetetrazole-evoked seizuresQ37321960
Purification of an endogenous protein inhibitor of the high affinity binding of gamma-aminobutyric acid to synaptic membranes of rat brainQ37593334
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Benzodiazepines: GABA and glycine receptors on single neurons in the rat medullaQ39099236
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Benzodiazepines: Potentiation of a GABA inhibitory response in the dorsal raphe nucleusQ39196019
GABAergic modulation of benzodiazepine binding site sensitivityQ39201870
The effect of γ-aminobutyric acid on 3H-flunitrazepam binding in rat brainQ39212815
Benzodiasepine and neurotransmitter receptor binding in rat brain after chronic administration of diazepam or phenobarbitalQ39217288
Behavioural evidence for GABAergic activity of the benzodiazepine flurazepamQ39217999
Enhancement of 3H-diazepam binding by SQ 65,396: A novel anti-anxiety agentQ39240681
Modulation of benzodiazepine binding sites in calf cortex by an endogenous factor and GABAergic ligandsQ39251728
Molecular Mechanisms in the Receptor Action of BenzodiazepinesQ39255212
Biochemical pharmacology of Gabaergic agonistsQ39258573
Putative benzodiazepine receptor: A protein solubilised from brainQ39269213
Solubilization of benzodiazepine binding site from rat cortexQ39270713
Some properties of brain specific benzodiazepine receptors: New evidence for multiple receptorsQ39277925
Regional distribution of Na+-independent GABA and benzodiazepine binding sites in rat CNSQ39286447
In vivo receptor occupation by benzodiazepines and correlation with the pharmacological effectQ39286452
Phenobarbitone modulation of postsynaptic GABA receptor function on cultured mammalian neuronsQ39300993
Opiate receptors and opioid peptidesQ39302121
Involvement of gamma-amino butyric acid (GABA) in the anticonvulsant action of methaqualoneQ39602962
Inhibitory, GABAergic Nerve Terminals Decrease at Sites of Focal EpilepsyQ39667726
Inhibitors of GABA metabolismQ39805656
Nicotinamide is a brain constituent with benzodiazepine-like actionsQ39880919
Penicillin decreases chloride conductance in crustacean muscle: a model for the epileptic neuronQ39988975
Interaction of pentobarbitone and gamma-aminobutyric acid on mammalian sympathetic ganglion cellsQ40052502
Reversal of the action of amino acid antagonists by barbiturates and other hypnotic drugsQ40052721
GABA receptor binding with 3H (+) bicuculline–methiodide in rat CNSQ40068234
Pentylenetetrazol and penicillin are selective antagonists of GABA-mediated post-synaptic inhibition in cultured mammalian neuronesQ40080548
Receptors for the Age of Anxiety: Pharmacology of the BenzodiazepinesQ40081698
A new class of GABA agonistQ40086160
Neurotransmitter receptors-biochemistry and alterations in nueropsychiatric disordersQ40121738
Inhibitors of the GABA uptake systemsQ40121757
Effects of drugs on γ-aminobutyric acid receptors, uptake, release and synthesis in vitroQ48218826
Effect of GABAergic drugs on benzodiazepine binding site sensitivity in rat cerebral cortexQ48223668
Benzodiazepine receptor: demonstration in the central nervous systemQ48250292
Influences ions, enzymes, and detergents on gamma-aminobutyric acid-receptor binding in synaptic membranes of rat brainQ48294295
Anticonvulsant action of diazepam: increase of cortical postsynaptic inhibitionQ48308697
The mechanism of action of diphenylhydantoin or invertebrate neurons. I. Effects on basic membrane propertiesQ48316952
Central actions of benzodiazepinesQ48343593
Pentobarbital selectively enhances GABA-mediated post-synaptic inhibition in tissue cultured mouse spinal neuronsQ48362928
Neurochemical aspects of the ontogenesis of GABAnergic neurons in the rat brainQ48375477
Diphenylhydantoin increases cortical postsynaptic inhibitionQ48392999
Prolongation of hippocampal inhibitory postsynaptic potentials by barbituratesQ48425020
Tetramethylenedisulphotetramine and amino acid inhibition in the rat brainQ48442742
β-Carboline-3-carboxylic acid ethyl ester antagonizes diazepam activityQ51871501
Kainic acid differentiates GABA receptors from benzodiazepine receptors in the rat cerebellumQ51875355
Pentobarbital potentiates GABA-enhanced [3H]-diazepam binding to benzodiazepine receptors.Q51875371
The effects of pentobarbital and related compounds on frog motoneuronsQ51875846
Interaction of diphenylhydantoin and benzodiazepines in the CNS.Q51876245
Purine inhibition of [3H]-gamma-aminobutyric acid receptor binding to rat brain membranes.Q51876300
The inhibition of GABA-stimulated benzodiazepine binding by a convulsant benzodiazepine.Q51876631
Displacement of [3H] diazepam binding in rat brain by dipyridamole and by 1-methylisoguanosine, a marine natural product with muscle relaxant activity.Q51877144
Supersensitivity to GABA's effect on benzodiazepine receptors develops after striatonigral lesions.Q51877177
Facilitation of specific benzodiazepine binding in rat brain membrane fragments by a number of anions.Q51877872
Identification of an endogenous peptide-ligand for the benzodiazepine receptor.Q51877908
Changes in benzodiazepine receptors following gabaergic denervation of substantia nigraQ52701537
Benzodiazepines specifically modulate GABA-mediated postsynaptic inhibition in cultured mammalian neuronesQ52706678
Effects of a convulsant barbiturate on the spinal monosynaptic pathway.Q54590355
Studies on convulsants in the isolated frog spinal cord. I. Antagonism of amino acid responsesQ54628419
Bicyclic phosphorus esters that are potent convulsants and GABA antagonistsQ56866899
Modulation by picrotoxin and IPTBO of 3H-flunitrazepam binding to the GABA/benzodiazepine receptor complex of rat cerebellumQ64410470
Thip and isoguvacine are partial agonists of GABA-stimulated benzodiazepine receptor bindingQ66972310
Stimulation of benzodiazepine receptor binding by SQ 20009 is chloride-dependent and picrotoxin-sensitiveQ66980276
Water soluble benzodiazepines with agonistic and antagonistic actions on GABA-induced inhibition in cultured hypothalamusQ67020111
Pentobarbitone enhancement of the inhibitory action of GABAQ67045773
Stereospecific interaction of bicuculline with specific [3H]strychnine binding to rat spinal cord synaptosomal membranesQ67288256
gamma-Aminobutyric acid-stimulated chloride permeability in crayfish muscleQ67547537
[Effect of diazepam on presynaptic inhibition and other spinal reflexes]Q68580693
Pentobarbital: stereospecific actions of (+) and (-) isomers revealed on cultured mammalian neuronsQ71128500
Evidence that bicuculline and picrotoxin act at separate sites to antagonize gamma-aminobutyric acid in rat cuneate nucleusQ71147777
Release of endogenous amino acid neurotransmitter candidates from rat olfactory cortex slices: possible regulatory mechanisms and the effects of pentobarbitoneQ71179951
Soluble benzodiazepine receptors: GABAergic regulationQ71218575
Solubilization of the benzodiazepine receptor from rat brainQ71218581
Solubilization of gamma-aminobutyric acid receptor from rat brainQ71246763
The binding of 3H-isoguvacine to mouse brain synaptic membranesQ71246784
Ethanol specifically potentiates GABA-mediated neurotransmission in feline cerebral cortexQ71251678
Endogenous inhibitors of picrotoxinin-convulsant binding sites in rat brainQ71265378
GABA binding in mammalian brain: inhibition by endogenous GABAQ71371841
Electrophysiological actions of benzodiazepinesQ40121993
Dihydropicrotoxinin binding to crayfish muscle sites possibly related to gamma-aminobutyric acid receptor-ionophoresQ40153801
Binding of [3H]alpha-dihydropicrotoxinin, a gamma-aminobutyric acid synaptic antagonist, to rat brain membranesQ40153805
Interaction of barbiturates with dihydropicrotoxinin binding sites related to the GABA receptor-ionophore systemQ40161259
Dihydropicrotoxinin binding sites in rat brain: comparison to GABA receptorsQ40164441
Gamma-aminobutyric acid binding in mammalian brain: receptor-like specificity of sodium-independent sitesQ40179296
Is stimulation of benzodiazepine receptor binding mediated by a novel GABA receptor?Q40219716
Solubilization of gamma-aminobutyric acid receptor protein from mammalian brainQ40243096
Potentiation of the effects of GABA by pentobarbitoneQ40244040
Biochemical evidence for two classes of GABA receptors in rat brainQ40251117
Gaba receptor-mediated modulation of 3H-diazepam binding in rat cortexQ40252343
Suppression of retinal spike discharge by dipropylacetate (depakene): A possible involvement of GABAQ40258142
Correlation between benzodiazepine receptor occupation and anticonvulsant effects of diazepamQ40298346
Properties of γ-aminobutyric acid (GABA) receptor binding in rat brain synaptic membrane fractionsQ40346759
Reduction of gamma-aminobutyric acid (GABA)-mediated transmission by a convulsant benzodiazepineQ41030495
Specific antagonism of GABA-mediated postsynaptic inhibition in cultured mammalian spinal cord neurons: A common mode of convulsant actionQ41035023
Valproic acid augments GABA-mediated postsynaptic inhibition in cultured mammalian neuronsQ41077408
Cage convulsants inhibit picrotoxinin bindingQ41583299
Enhancement of GABA-mediated postsynaptic inhibition in cultured mammalian spinal cord neurons: A common mode of anticonvulsant actionQ41611545
Purinergic inhibition of diazepam binding to rat brain ()Q41642453
Effect of diazepam on gabaergic cuneate neuronsQ41645500
Penicillin blocks hippocampal IPSPs, unmasking prolonged EPSPsQ41671998
Partial agonists for brain GABA/benzodiazepine receptor complexQ41700518
The GABA agonist THIP, a muscimol analogue, does not interfere with the benzodiazepine binding site on rats cortical membranesQ41702096
Influence of inhibitors of the high affinity GABA uptake on seizure thresholds in miceQ42153357
Cetyl GABA: effect on convulsant thresholds in mice and acute toxicityQ42271685
Leptazol antagonises the post-synaptic actions of gamma-aminobutyric acid [proceedings]Q42631515
Rapid changes in brain benzodiazepine receptors after experimental seizuresQ43543162
Localization of gamma-aminobutyric acid receptor binding in the mammalian cerebellum: high levels in granule layer and depletion in agranular cerebella of mutant miceQ43666749
Influence of GABA receptor agonists and antagonists on the binding of 3H-diazepam to the benzodiazepine receptorQ43721093
Pentylenetetrazol: An antagonist of gaba at primary afferents of the isolated frog spinal cordQ43761200
GABA-induced conductance fluctuations in cultured spinal neuronesQ44220638
Gamma-aminobutyric acid (GABA) receptor binding selectively depleted by viral induced granule cell loss in hamster cerebellumQ44527689
GABA receptor binding in rat striatum: localization and effects of denervationQ44614779
Convulsant drugs: amino acid antagonism and central inhibitionQ44670289
Synaptic mechanism of pentylenetetrazole: selectivity for chloride conductanceQ44753975
Benzodiazepine receptors in rat brainQ45205253
On the mechanism of barbiturate anaesthesiaQ46234151
Neurotransmitter receptor localizations: brain lesion induced alterations in benzodiazepine, GABA, beta-adrenergic and histamine H1-receptor bindingQ46521536
Presence of a low molecular weight endogenous inhibitor on 3H-muscimol binding in synaptic membranesQ47293923
Interactions between benzodiazepines and GABA in the cerebellar cortexQ48103165
Is the benzodiazepine receptor coupled to a chloride anion channel?Q48110016
Endogenous inhibitor of GABA binding in mammalian brainQ48190272
P304page(s)261-279
P577publication date1981-09-01
P1433published inMolecular and Cellular BiochemistryQ1573176
P1476titleThe GABA postsynaptic membrane receptor-ionophore complex. Site of action of convulsant and anticonvulsant drugs
P478volume39

Reverse relations

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