Inhibitors of angiotensin-converting enzyme

scientific article published on January 1980

Inhibitors of angiotensin-converting enzyme is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S0079-6468(08)70157-7
P698PubMed publication ID6273970

P2093author name stringOndetti MA
Cushman DW
P2860cites workA dipeptidyl carboxypeptidase that converts angiotensin I and inactivates bradykininQ24300463
The role of the renin-angiotensin-aldosterone system in cardiovascular homeostasis in normal human subjectsQ24305000
Substrate binding properties of converting enzyme using a series of p-nitrophenylalanyl derivatives of angiotensin IQ28320904
The biochemistry of the renin-angiotensin system and its role in hypertensionQ28321084
Central cardiovascular effects of SQ 14,225, an angiotensin-converting enzyme inhibitor in chloralose-anesthetized catsQ28321422
Angiotensin I converting enzyme from human plasmaQ28321477
Hypotension induced by inhibition of angiotensin-converting enzyme in pentobarbital-anesthetized dogsQ28322092
Potentiative effects of sulfhydryl compounds on carrageenin-induced oedema in rats and relationship to their potencies as inhibitors of angiostin-converting enzyme in vivoQ28322189
Converting Enzyme Inhibition Augments and Competitive Inhibition of Angiotensin II Partially Restores Reflex Adrenal Catecholamine Release in Anephric Dogs*Q28322318
Effects of chronic treatment with captopril (SQ 14,225), an orally active inhibitor of angiotensin I-converting enzyme, in spontaneously hypertensive ratsQ28323054
Potentiating mechanism of bradykinin action on smooth muscle by sulfhydryl compoundsQ28325832
Design of potent competitive inhibitors of angiotensin-converting enzyme. Carboxyalkanoyl and mercaptoalkanoyl amino acidsQ34089278
Fate of angiotensin I in the circulationQ34205913
Isolation of bradykinin-potentiating peptides from Bothrops jararaca venomQ34206488
Angiotensin-converting enzyme inhibitors from the venom of Bothrops jararaca. Isolation, elucidation of structure, and synthesisQ34206989
Inhibition by SQ 20881 of vasopressor response to angiotensin I in conscious animalsQ34207529
Binding of the by-product analog benzylsuccinic acid by carboxypeptidase AQ34217732
The preparation and function of the hypertensin-converting enzymeQ34238210
Subcellular distribution and properties of the bradykinin inactivation system in rabbit brain homogenatesQ34239314
Role of the renin-angiotensin system in the systemic vasoconstriction of chronic congestive heart failureQ67391109
Inhibition of renin secretion in the isolated rat kidney by angiotensin IQ67391691
Prolonged treatment of high-renin hypertension with a converting enzyme inhibitorQ67402564
The effect of the converting enzyme inhibitor SQ 20.881 on kinins, renin-angiotensin-aldosterone and catecholamines in relation to blood pressure in hypertensive patientsQ67434195
Effect of renin‐angiotensin system on sodium intakeQ67439932
The other angiotensinsQ67546951
Effect of angiotensin-converting enzyme inhibitor (SQ 20881) on the plasma concentration of angiotensin I, angiotensin II, and arginine vasopressin in the dog during hemorrhagic shockQ67652877
Inactivation of bradykinin the plumonary circulationQ67803826
Angiotensin converting enzyme: method of assay and partial purificationQ68605093
Studies on the angiotensin converting enzyme with different substratesQ68608796
Inhibition of angiotensin I converting enzyme and kininase in rabbit plasma by bradykinin potentiating peptide B (Pyr-Gly-Leu-Pro-Arg-Pro-Lys-Ile-Pro-Pro)Q68632310
Inhibition of angiotensin I-initiated hemodynamic changes in anesthetized dogs by a synthetic nonapeptideQ68642843
Angiotensin I converting enzyme of calf lung. Method of assay and partial purificationQ68644503
Purification and properties of angiotensin-converting enzyme from hog lungQ68647267
Effect of a converting enzyme inhibitor (SQ 20,881) on angiotensin-induced drinkingQ68653952
Effects of angiotensin I and antiotensin II on canine hepatic vascular resistanceQ68654564
Stimulation of splenic prostaglandin release by angiotensin and specific inhibition by cysteine 8-AIIQ68658034
Inhibition of homogeneous angiotensin-converting enzyme of rabbit lung by synthetic venom peptides of Bothrops jararacaQ68662321
Inhibition of angiotensin-coverting enzyme by analogs of peptides from Bothrops jararaca venomQ68668089
Bradykinin potentiating peptide PCA-Lys-Trp-Ala-Pro. An inhibitor of the pulmonary inactivation of bradykinin and conversion of angiotensin I to IIQ68669024
Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lungQ68669025
Effects of angiotensin I and angiotensin II on hindlimb and coronary vascular resistanceQ68669167
Hydrolysis of bradykinin by angiotensin-converting enzymeQ68686336
Effect of blockade of angiotensin-I converting enzyme on the blood pressure of renal hypertensive rabbitsQ68703286
On the role of vasopressin and angiotensin in the development of irreversible haemorrhagic shockQ68704129
studies of plasma bradykininases using radiolabelled substratesQ68706866
Angiotensin-converting enzyme from porcine plasmaQ68713088
Effect of a renal prostaglandin on distribution of blood flow in the isolated canine kidneyQ69775419
Letter: Hypotension during administration of angiotensin converting enzyme inhibitor SQ 20,881Q70022577
Structure of bradykinin-potentiating peptide containing tryptophan from the venom ofAgkistrodon halys blomhoffiiQ71726060
Characteristics and Significance of Prodromes of Coronary Care Unit PatientsQ71751191
Potentiation of the cerebral vascular action of bradykinin by the 'bradykinin potentiating factor' (BPF) in the dogQ72662866
Potentiation of bradykinin and eledoisin by BPF (bradykinin potentiating factor) from Bothrops jararaca venomQ72668344
Greene LL, Ferreira SH: Potential screening test for detection of overactivity of renin-angiotensin systemQ93695904
Reduction of pressor effects of angiotensin I in man by synthetic nonapeptide (B.P.P. 9a or SQ 20,881) which inhibits converting enzymeQ93731616
Effect of angiotensin-converting enzyme inhibitor on response of plasma renin activity and aldosterone to tilting in man.Q34451342
The existence of two forms of hypertensinQ34648778
Activity of various fractions of bradykinin potentiating factor against angiotensin I converting enzymeQ34698149
Inhibition of angiotensin I converting enzyme by venom peptidesQ34698491
An angiotensin converting-enzyme inhibitor to identify and treat vasoconstrictor and volume factors in hypertensive patientsQ34698738
Design of Specific Inhibitors of Angiotensin-Converting Enzyme: New Class of Orally Active Antihypertensive AgentsQ34936463
Mechanism and modification of bradykinin-induced coronary vasodilationQ35080604
The effect of angiotensin I converting enzyme inhibitor (SQ 20881) on the release of prostaglandins by rabbit kidney, in vivoQ35176470
Pulmonary metabolism of bradykinin analogues and the contribution of angiotensin converting enzyme to bradykinin inactivation in isolated lungsQ35176902
The renin-angiotensin-aldosterone system in congestive failure in conscious dogsQ35202042
Modification of responses to sympathetic nerve stimulation by the renin-angiotensin system in ratsQ35603306
Role of extrapulmonary conversion in mediating the systemic pressor activity of angiotensin I.Q36273600
Biological and biochemical properties of angiotensin-converting enzymeQ37112975
Converting enzyme inhibition and blood pressure regulationQ37113027
Angiotensin-Converting Enzyme and the Regulation of Vasoactive PeptidesQ37116751
Renin-angiotensin system: biochemistry and mechanisms of actionQ37382695
Angiotensin-converting enzyme from rabbit pulmonary particlesQ37442746
Regulation of aldosterone secretion by the renin-angiotensin system during sodium restriction in ratsQ37593464
Escherichia coli mutants defective in dipeptidyl carboxypeptidaseQ37596321
The renin system in high blood pressure, from disbelief to reality: Converting-enzyme blockade for analysis and treatmentQ37863779
Design of new antihypertensive drugs: Potent and specific inhibitors of angiotensin-converting enzymeQ37863817
Captopril (SQ 14,225) (d-3-mercapto-2-methylpropanoyl-l-proline): A novel orally active inhibitor of angiotensin-converting enzyme and antihypertensive agentQ37863825
Kinetic properties of pulmonary angiotensin-converting enzyme. Hydrolysis of hippurylglycylglycineQ39087186
The effects of angiotensin I and angiotensin II on the isolated tracheal muscle of the catQ39099201
Renal Angiotensin I-Converting Enzyme as a Mixture of Sialo- and Asialo-enzyme, and a Rapid Purification MethodQ39117695
Modern system for treating high blood pressure based on renin profiling and vasoconstriction-volume analysis: A primary role for beta blocking drugs such as propranololQ39119930
Response to angiotensins I and II and to AI-converting-enzyme inhibitor in a sharkQ39129533
Purification of angiotensin I-converting enzyme from human lungQ39158466
Equine angiotensin converting enzyme: a zinc metalloenzymeQ39159015
A fluorogenic substrate for angiotensin-converting enzymeQ39171105
Substance P degradation by rat brain peptidases: inhibition by SQ 20881.Q39242200
A specific orally active inhibitor of angiotensin-converting enzyme in man.Q39429288
Correction of renal hypertension in the rat by prolonged infusion of angiotensin inhibitorsQ39472653
Innappropriate renin secretion unmasked by captopril (SQ 14 225) in hypertension of chronic renal failureQ39507490
Effects of SQ 14,225, an orally active inhibitor of angiotensin-converting enzyme on blood pressure, heart rate and plasma renin activity of conscious normotensive dogsQ40183347
Chronic antihypertensive effects of captopril (SQ 14,225), an orally active angiotensin I-converting enzyme inhibitor, in conscious 2-kidney renal hypertensive ratsQ40183353
Drinking in water deprived rats after combined central angiotensin receptor and converting enzyme blockadeQ40186122
Peptidyl dipeptidase in rabbit brain microvesselsQ40188024
Angiotensin-converting enzyme: Presence of high activity in choroid plexus of mammalian brainQ40189063
Studies on the hydrolysis of bradykinin by angiotensin-converting enzyme (kininase II)Q40189150
Clinical experience with blockade of the renin-angiotensin-aldosterone system by an oral converting-enzyme inhibitor (SQ 14,225, captopril) in hypertensive patientsQ40192276
Peptide inhibitors of angiotensin I-converting enzyme in digests of gelatin by bacterial collagenaseQ40196323
Inhibition of the renin-angiotensin-system in brattleboro rats with hereditary hypothalamic diabetes insipidusQ40199535
Oral Angiotensin-Converting Enzyme Inhibitor in Long-Term Treatment of Hypertensive PatientsQ40207778
The effects of kininase II inhibition by SQ 14225 on kidney kallikrein-kinin and prostaglandin systems in conscious dogsQ40216628
Hemodialysis-Resistant Hypertension: Control with an Orally Active Inhibitor of Angiotensin-Converting Enzyme*Q40217788
Effect of Angiotensin Converting Enzyme Inhibition on Blood Pressure, Plasma Renin Activity and Plasma Aldosterone in Essential Hypertension *Q40224866
Modification by SQ 14225 of blood pressure and adrenal catecholamine response to hemorrhageQ40237895
Action of Angiotensin I Converting Enzyme Inhibitor on the Control of Renal Function in the CatQ40251816
Mechanism of angiotensin I converting enzyme inhibition by SQ20,881 (less than Glu-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro) in vivo. Further evidence for extrapulmonary conversionQ40294571
Converting enzyme inhibition with an orally active compound in hypertensive manQ40294575
Prior receptor occupancy as a determinant of the pressor activity of infused angiotensin II in the ratQ40308391
Inhibition of angiotensin conversion and prevention of renal hypertensionQ40310776
The role of the renin-angiotensin system in the initiation of renovascular hypertensionQ40670045
Renin-angiotensin system inhibition in conscious dogs during acute hypoxemia. Effects on systemic hemodynamics, regional blood flows, and tissue metabolismQ40688762
Hemodynamic characteristics of hypertension after coronary bypass surgery and effects of the converting enzyme inhibitorQ40702845
The mechanism of action of two bradykinin-potentiating peptides on isolated smooth muscleQ41011679
Adrenal Responses to Pharmacological Interruption of the Renin-Angiotensin System in Sodium-Restricted Normal Man*Q41022879
Prolongation of the saralasin responsive state of two-kidney, one clip Goldblatt hypertension in the rat by the orally administered converting enzyme inhibitor captopril (SQ14,225)Q41187217
Converting Enzyme Inhibition in Hypertensive EmergenciesQ41437183
Synthesis and pharmacology of a prohormone angiotensin antagonistQ41445544
Design of potent and specific inhibitors of carboxypeptidases A and BQ41482450
Angiotensin-Converting Enzyme Inhibitor (SQ 20881) in the Diagnosis of Renovascular HypertensionQ41536202
The role of angiotensin in the canine renal vascular response to barbiturate anesthesiaQ41784310
Hydrolysis of bradykinin and its higher homologues by angiotensin-converting enzymeQ41862200
Effect of converting enzyme blockade on isoprenaline- and angiotensin I-induced drinkingQ41912640
Angiotensin blockade: its clinical significanceQ42001746
The bradykininase activities of extracts of dog lungQ43002601
Inhibitors of the pulmonary angiotensin I-converting enzymeQ43468107
Effect of the inhibition of angiotensin I converting enzyme in endotoxin and hemorrhagic shock.Q43725310
Evidence for myocardial conversion of angiotensin I.Q43918557
Conversion of angiotensin I into angiotensin II in the isolated perfused rat kidneyQ43938264
In vitro study on the effects of bradykinin potentiating factor and angiotensin II analogue on degradation and conversion of angiotensin I and II in plasmaQ43938789
The effects of angiotensin II blockade in conscious sodium-depleted dogsQ43973249
Metabolism of the angiotensins in isolated perfused tissuesQ43983009
Effects of Diphenylhydantoin on Excitability and Automaticity in the Canine HeartQ44046281
Bradykinin potentiating and sensitizing activities of new synthetic analogs of snake venom peptidesQ44052825
Alkylating analogs of peptide hormones. 1. Synthesis and properties of p-(N,N-)-bis(2-chloroethyl)amino)phenylbutyryl derivatives of bradykinin and bradykinin potentiating factorQ44089793
Effect of the synthetic peptide, Sq 20,881, on distribution of blood flow in the rat.Q44105991
Converting enzyme inhibitor and saralasin infusion in rats. Evidence for an additional vasodepressor property of converting enzyme inhibitorQ44137963
Letter: Hypotensive effect of angiotensin-converting-enzyme inhibitor SQ 20,881.Q44184476
Angiotensin and thirst: studies with a converting enzyme inhibitor and a receptor antagonistQ44210833
Contractile Responses to Angiotensin l and Angiotensin II in Hamster Uterine Smooth MuscleQ44493250
Des-Asp1-angiotensin I: a metabolite of angiotensin I in the perfused feline adrenalQ44629775
Continuous angiotensin II blockade throughout the acute phase of one-kidney hypertension in the dogQ44789325
Specific stimulation and inhibition of renal prostaglandin release by angiotensin analogsQ45049275
The cost of scientific communication: the scientist as ad-manQ45099384
Renal vascular response to interruption of the renin-angiotensin system in normal manQ45796029
Structure-activity relationships of bradykinin potentiating peptidesQ46151311
Bradykinin-potentiating peptides from the venom of Agkistrodon halys blomhoffi. Isolation of five bradykinin potentiators and the amino acid sequences of two of them, potentiators B and C.Q46438588
Structure of potentiator A, one of the five bradykinin potentiating peptides from the venom of Agkistrodon halys blomhoffiiQ46491129
The renin--angiotensin system: inhibition of converting enzyme in isolated tissuesQ46596530
New sulfhydryl compounds with potent antihypertensive activitiesQ46606977
In vivo and in vitro conversion of des-1-Asp angiotensin I to angiotensin IIIQ46678742
Bradykinin-potentiating peptides from the venom ofAgkistrodon halys blomhqffiiQ46756248
The bradykinin potentiating activity of two pentapeptides on various isolated smooth muscle preparationsQ46759206
Peptide inhibitors of pulmonary angiotensin I converting enzymeQ46868311
Application of mass spectrometry to sequence analysis of pyroglutamyl peptides from snake venoms: contribution to the confirmation of the amino acid sequence of bradykinin-potentiating peptides B, C and E isolated from the venom of Agkistrodon halysQ47924592
Improvement of chronic congestive heart-failure by oral captoprilQ39550043
Autonomic neural influences on the dysrhythmias resulting from myocardial infarctionQ39725287
Agents which block the action of the renin-angiotensin systemQ39900497
Specific inhibition of the renin-angiotensin system: A key to understanding blood pressure regulationQ39902030
Angiotensin-converting enzyme in human brainQ39933249
Disappearance of bradykinin in the renal circulation of dogs. Effects of kininase inhibitionQ39942256
Formation of angiotensin II from tetradecapeptide renin substrate by angiotensin-converting enzymeQ39946397
Elevation of serum angiotension-converting-enzyme (ACE) level in sarcoidosisQ39950095
Increase in cyclic AMP levels and vasopressin release in response to angiotensin I in neurohypophyses: Blockade following inhibition of the converting enzymeQ39963399
Synthesis and evaluation of [des-Asp1]angiotensin I as a precursor for [des-Asp1]angiotensin II (angiotensin III)Q39963512
The Inhibition of Angiotensin Converting Enzyme in Chronic Renal Hypertension by a Synthetic PeptideQ39970321
Elevation of Serum Angiotensin-Converting Enzyme in Gaucher's DiseaseQ39991377
The inactivation of bradykinin in the pulmonary circulation of isolated lungsQ39994147
Formation of angiotensin III by angiotensin-converting enzymeQ40000291
Carboxypeptidase A: a protein and an enzyme.Q40005857
Angiotensin I-converting enzyme from guinea pig lung and serum. A comparison of some kinetic and inhibition propertiesQ40006349
Correlation of pulmonary structure with pharmacokinetic functionQ40012099
Similarity in some properties of serum angiotensin converting enzyme from sarcoidosis patients and normal subjectsQ40013578
Role of Converting Enzyme in the Cardiovascular and Adrenal Cortical Responses to (des-Asp)-Angiotensin IQ40016878
Action of bradykinin potentiating factor (BPF) and dimercaprol (BAL) on the responses to bradykinin of isolated preparations of rat intestinesQ40017862
Vascular angiotensin receptors and their role in blood pressure controlQ40024590
Estimating renin participation in hypertension: Superiority of converting enzyme inhibitor over saralasinQ40024598
Solubilization of angiotensin I-Converting enzyme from rabbit lung using trypsin treatmentQ40025790
The Renin-Angiotensin System and Thirst: A ReevaluationQ40029278
(Des-Asp1) Angiotensin I: A Study of its Pressor and Steroidogenic Activities in Conscious Rats*Q40032280
Endocrine and Cardiovascular Consequences of Angiotensin Converting Enzyme InhibitionQ40048963
Possible Role of Renin in Hypertension as Suggested by Renin-Sodium Profiling and Inhibition of Converting EnzymeQ40052344
Effect of intrarenal angiotensin II blockade on renal function in conscious dogsQ40057167
Some enzymatic properties of peptidyl dipeptide hydrolase (angiotensin I-converting enzyme).Q40058631
Dose response of SQ 20,858 in chronic renal hypertensionQ40075460
Accentuated Vascular and Endocrine Response to Sq 20881 in HypertensionQ40080419
Rabbit tissue peptidases that hydrolyse the peptide hormone bradykinin. Differences in enzymic properties and concentration in rabbit tissuesQ40082692
Peptide inhibitors of converting enzymeQ40108103
Effect of the inhibitor of angiotensin i converting enzyme on endocrine function and renal perfusion in haemorrhagic shockQ40116713
Inhibition of angiotensin converting enzyme by SQ 14,225 in conscious rabbitsQ40117360
Properties of three different forms of angiotensin I-converting enzyme from human lungQ40122289
Effects of the Oral Converting Enzyme Inhibitor (SQ 14225) on One-Kidney Hypertension in the DogQ40125982
Soluble dextran complexes of Kallikrein, Bradykinin and enzyme inhibitorsQ40127777
Inhibition of Angiotensin-Converting Enzyme for Diagnosis of Renal-Artery StenosisQ40130936
Antihypertensive Effect of the Oral Angiotensin Converting-Enzyme Inhibitor SQ 14225 in ManQ40141803
Subcellular localization and partial purification of a chloride dependent angiotensin-I converting enzyme from rat brainQ40146562
Inhibition of brain angiotensin-1 converting enzyme by Bothrops jararaca nonapeptide (SQ 20881) and a prolyl analog (SQ 14225)Q40160400
Beneficial action of new angiotensin-converting enzyme inhibitor (SQ 14,225) in hemorrhagic shock in catsQ40170709
Functional residues at the active site of angiotensin converting enzymeQ40176791
Intestinal vasoconstriction following diuretic-induced volume depletion: role of angiotensin and vasopressinQ48536116
Drinking induced by injections of angiotensin into forebrain and mid-brain sites of the monkeyQ48553560
Inhibition of central pressor effects of agiotensin I and II.Q48568697
Renin-angiotensin role in thirst: paradoxical enhancement of drinking by angiotensin converting enzyme inhibitorQ48612826
Differential distribution of angiotensin converting enzyme in the anterior and posterior lobe of the rat pituitaryQ48629202
Angiotensin I as a dipsogen: efficacy in brain independent of conversion to angiotensin II.Q48648635
Characterization of central angiotensin II receptors involved in the elicitation of drinking in the rat.Q48686756
Distribution and properties of angiotensin converting enzyme of rat brainQ48724652
Antinociceptive action of intraventricular bradykininQ51117182
Concentrations of angiotensin-converting enzyme in tissues of the rat.Q51120575
Angiotensin-converting enzyme from guinea pig and hog lung.Q52996248
Human plasma converting enzyme.Q53735315
Inhibition of angiotensin conversion in experimental renovascular hypertension.Q53786150
Contribution of intrarenal generation of prostaglandin to autoregulation of renal blood flow in the dog.Q53791563
Carboxycathepsin--a key regulatory component of two physiological systems involved in regulation of blood pressure.Q53814616
Synthesis and properties of new bradykinin potentiating peptidesQ53999813
Cleavage of active peptides by a lung enzyme.Q54037130
Substrate specificity of hog plasma angiotensin-converting enzyme.Q54146130
Conversion of angiotensin I to angiotensin II in the canine mesenteric circulation.Q54312632
Angiotensin I-converting enzyme of the kidney cortex.Q54600740
Bradykinin analogs containing .beta.-homoamino acidsQ54624709
Effect of angiotensin converting enzyme inhibition on renal autoregulation.Q54637638
Inhibition of converting enzyme of the renin-angiotensin system in kidneys and hindlegs of dogs.Q54642466
Intrarenal conversion of angiotensin I to angiotensin II in the dog.Q54665383
Pharmacology of antagonists of angiotensin I and II.Q54704240
Conversion of Angiotensin I to Angiotensin II by Cell-free Extracts of Dog LungQ59076950
Experiment to detect Pulsed γ-Rays from the Crab NebulaQ59076955
Conversion of angiotensin I to angiotensin IIQ66846278
Role of converting enzyme in the responses of rabbit atria, aortas, and adrenal zona glomerulosa to [des-Asp1]angiotensin IQ66846864
Failure of renin suppression by angiotensin II in hypertensionQ67242144
Slow conduction and reentry in the ventricular conducting system. II. Single and sustained circus movement in networks of canine and bovine Purkinje fibersQ67269442
Paradoxical inhibition of the effects of bradykinin by some sulfhydryl reagentsQ67298594
Mechanism of blood pressure reduction by teprotide (SQ 20881) in ratsQ67330950
Hydrolysis of enkephalin by cultured human endothelial cells and by purified peptidyl dipeptidaseQ67338698
Quantitative analysis of the acute response to haemorrhage of the renin-angiotensin-vasoconstrictor feedback loop in areflexic dogsQ67353062
Angiotensin converting enzyme inhibition in patients with congestive heart failureQ67391111
P304page(s)41-104
P577publication date1980-01-01
P1433published inProgress in medicinal chemistryQ27712806
P1476titleInhibitors of angiotensin-converting enzyme
P478volume17

Reverse relations

cites work (P2860)
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Q35811130Digestion and assimilation of proline-containing peptides by rat intestinal brush border membrane carboxypeptidases. Role of the combined action of angiotensin-converting enzyme and carboxypeptidase P.
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Q34255117The Catalytic Mechanism of Angiotensin Converting Enzyme

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