Genetic variants of TRAF6 modulate peritoneal immunity and the risk of spontaneous bacterial peritonitis in cirrhosis: A combined prospective-retrospective study

scientific article published on 7 July 2017

Genetic variants of TRAF6 modulate peritoneal immunity and the risk of spontaneous bacterial peritonitis in cirrhosis: A combined prospective-retrospective study is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-017-04895-Z
P932PMC publication ID5501819
P698PubMed publication ID28687809

P2093author name stringAndreas Stallmach
Tony Bruns
Ignacio Rubio
Sven Stengel
Caroline Schmidt
Eihab Al-Herwi
Jack Peter
Martina Mai
P2860cites workAn integrated map of genetic variation from 1,092 human genomesQ22122153
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complexQ24295120
PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12Q24323912
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
The International HapMap ProjectQ27860695
Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signalingQ28278006
TRAF6 Is a Critical Factor for Dendritic Cell Maturation and DevelopmentQ28505658
HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variantsQ29614906
Thrombocytopenia identifies a severe familial phenotype of systemic lupus erythematosus and reveals genetic linkages at 1q22 and 11p13.Q33344870
Evaluation of TRAF6 in a large multiancestral lupus cohortQ33399089
Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profileQ33656103
TLR signalling augments macrophage bactericidal activity through mitochondrial ROS.Q34180844
The INCA trial (Impact of NOD2 genotype-guided antibiotic prevention on survival in patients with liver Cirrhosis and Ascites): study protocol for a randomized controlled trial.Q35177083
Discovery of small molecule CD40-TRAF6 inhibitorsQ35549406
Genetic variation in the TNF receptor-associated factor 6 gene is associated with susceptibility to sepsis-induced acute lung injuryQ36338552
Analysis of monocyte chemotactic protein-1 gene polymorphism in patients with spontaneous bacterial peritonitisQ37445624
Risk factors and outcome of bacterial infections in cirrhosisQ37629681
EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosisQ37773059
Immune dysfunction and infections in patients with cirrhosisQ37852409
Spontaneous bacterial peritonitis: recent guidelines and beyondQ37965448
Systemic inflammation in decompensated cirrhosis: Characterization and role in acute-on-chronic liver failureQ39533703
Nucleotide-Binding Oligomerization Domain-Containing Protein 2 Variants in Patients with Spontaneous Bacterial PeritonitisQ40847568
A variant in the nuclear dot protein 52kDa gene increases the risk for spontaneous bacterial peritonitis in patients with alcoholic liver cirrhosis.Q40940501
Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chainsQ42412022
Soluble urokinase plasminogen activator receptor is compartmentally regulated in decompensated cirrhosis and indicates immune activation and short-term mortalityQ43490218
Bacterial infection in patients with advanced cirrhosis: a multicentre prospective study.Q44105999
Recurrence of spontaneous bacterial peritonitis in cirrhosis: frequency and predictive factorsQ44178776
High-density SNP analysis of 642 Caucasian families with rheumatoid arthritis identifies two new linkage regions on 11p12 and 2q33.Q44922542
Infections in patients with cirrhosis increase mortality four-fold and should be used in determining prognosisQ45569255
EASL clinical practice guidelines for HFE hemochromatosisQ46110938
NOD2 gene variants are a risk factor for culture-positive spontaneous bacterial peritonitis and monomicrobial bacterascites in cirrhosis.Q53234198
Acute-on-Chronic Liver Failure Is a Distinct Syndrome That Develops in Patients With Acute Decompensation of CirrhosisQ56925206
Further evidence for the relevance of TLR2 gene variants in spontaneous bacterial peritonitisQ58097238
Nucleotide-binding oligomerization domain containing 2 (NOD2) variants are genetic risk factors for death and spontaneous bacterial peritonitis in liver cirrhosisQ82578771
Toll-like receptor (TLR) 2 promoter and intron 2 polymorphisms are associated with increased risk for spontaneous bacterial peritonitis in liver cirrhosisQ83486899
Low ascitic fluid protein does not indicate an increased risk for spontaneous bacterial peritonitis in current cohortsQ85220793
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectspontaneous bacterial peritonitisQ3128789
P304page(s)4914
P577publication date2017-07-07
P1433published inScientific ReportsQ2261792
P1476titleGenetic variants of TRAF6 modulate peritoneal immunity and the risk of spontaneous bacterial peritonitis in cirrhosis: A combined prospective-retrospective study
P478volume7

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cites work (P2860)
Q91782424Analysis of Risk Factors for Patients with Liver Cirrhosis Complicated with Spontaneous Bacterial Peritonitis
Q90066254Can Macrophages in Cirrhotic Ascites Fluid Predict Clinical Outcome in Spontaneous Bacterial Peritonitis?
Q47299173Functional polymorphisms of innate immunity receptors are not risk factors for the non-SBP type bacterial infections in cirrhosis.
Q92745001Mucosal-Associated Invariant T Cells Redistribute to the Peritoneal Cavity During Spontaneous Bacterial Peritonitis and Contribute to Peritoneal Inflammation

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