Antigen presenting cell-targeted proinsulin expression converts insulin-specific CD8+ T-cell priming to tolerance in autoimmune-prone NOD mice

scientific article published on 30 June 2017

Antigen presenting cell-targeted proinsulin expression converts insulin-specific CD8+ T-cell priming to tolerance in autoimmune-prone NOD mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/EJI.201747089
P698PubMed publication ID28665492

P50authorEmma E Hamilton-WilliamsQ55089467
Raymond J SteptoeQ59556035
F. Susan WongQ63411298
P2093author name stringRajeev Rudraraju
Peta L S Reeves
P2860cites workAssociation of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune diseaseQ28201947
Differential antigen processing by dendritic cell subsets in vivoQ29615177
Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjectsQ33604570
Insulin as a key autoantigen in the development of type 1 diabetesQ33712227
Idd9.2 and Idd9.3 protective alleles function in CD4+ T-cells and nonlymphoid cells to prevent expansion of pathogenic islet-specific CD8+ T-cells.Q33869811
Genes within the Idd5 and Idd9/11 diabetes susceptibility loci affect the pathogenic activity of B cells in nonobese diabetic miceQ33918370
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunityQ33918375
Analysis of structure and function relationships of an autoantigenic peptide of insulin bound to H-2K(d) that stimulates CD8 T cells in insulin-dependent diabetes mellitusQ34025467
Contribution of TCR signaling strength to CD8+ T cell peripheral tolerance mechanismsQ34218620
Prime role for an insulin epitope in the development of type 1 diabetes in NOD miceQ34345367
Transfer of hematopoietic stem cells encoding autoantigen prevents autoimmune diabetesQ34984972
Blockade of PD-1/PD-L1 promotes adoptive T-cell immunotherapy in a tolerogenic environmentQ35151883
Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP.Q35191064
Expansion of Th17 cells and functional defects in T regulatory cells are key features of the pancreatic lymph nodes in patients with type 1 diabetesQ35405076
Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic MiceQ36255326
Tolerance in TCR/cognate antigen double-transgenic mice mediated by incomplete thymic deletion and peripheral receptor downregulationQ36511171
Hematopoietic stem-cell defects underlying abnormal macrophage development and maturation in NOD/Lt mice: defective regulation of cytokine receptors and protein kinase C.Q36603252
Type 1 diabetes patients have significantly lower frequency of plasmacytoid dendritic cells in the peripheral bloodQ37014824
Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetesQ37163535
APC dysfunction is correlated with defective suppression of T cell proliferation in human type 1 diabetesQ37165433
T cell-positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigensQ37202148
Incomplete clonal deletion as prerequisite for tissue-specific minor antigen tolerizationQ37277174
Perinatal tolerance to proinsulin is sufficient to prevent autoimmune diabetesQ37277296
Expression of diabetes-associated genes by dendritic cells and CD4 T cells drives the loss of tolerance in nonobese diabetic miceQ37323483
CD8+ T cells in type 1 diabetesQ37358997
Proinsulin Expression Shapes the TCR Repertoire but Fails to Control the Development of Low-Avidity Insulin-Reactive CD8+ T Cells.Q37643235
Revisiting regulatory T cells in type 1 diabetesQ38021600
Peripheral Proinsulin Expression Controls Low-Avidity Proinsulin-Reactive CD8 T Cells in Type 1 Diabetes.Q40586866
Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8+ T cell tolerance.Q40647086
The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cellsQ41146074
Immunogenic, but not steady-state, antigen presentation permits regulatory T-cells to control CD8+ T-cell effector differentiation by IL-2 modulation.Q41869061
Targeting antigen to diverse APCs inactivates memory CD8+ T cells without eliciting tissue-destructive effector functionQ44234403
Persistence of recipient lymphocytes in NOD mice after irradiation and bone marrow transplantation.Q44778818
Nonmyeloablative conditioning generates autoantigen-encoding bone marrow that prevents and cures an experimental autoimmune diseaseQ45879745
CD8+ T cell tolerance in nonobese diabetic mice is restored by insulin-dependent diabetes resistance alleles.Q53850293
Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells.Q53859655
Increased generation of dendritic cells from myeloid progenitors in autoimmune-prone nonobese diabetic mice.Q53971841
Deficiency in NOD antigen-presenting cell function may be responsible for suboptimal CD4+CD25+ T-cell-mediated regulation and type 1 diabetes development in NOD mice.Q54594961
Steady-state dendritic cells expressing cognate antigen terminate memory CD8+ T-cell responsesQ57667259
Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic miceQ71909256
Defective central tolerance induction in NOD mice: genomics and geneticsQ81552095
Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetesQ82746957
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)1550-1561
P577publication date2017-06-30
P1433published inEuropean Journal of ImmunologyQ5412727
P1476titleAntigen presenting cell-targeted proinsulin expression converts insulin-specific CD8+ T-cell priming to tolerance in autoimmune-prone NOD mice
P478volume47

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Q90413377Regulatory dendritic cells: profiling, targeting, and therapeutic applicationcites workP2860

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