Recurrent rhinovirus infections in a child with inherited MDA5 deficiency. (scientific article)

Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013

Q28083357

Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome

Q28389050

Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

Q29615029

Viruses and bacteria in the etiology of the common cold

Q33657199

Dissecting childhood asthma with nasal transcriptomics distinguishes subphenotypes of disease

Q33705765

TM4SF20 ancestral deletion and susceptibility to a pediatric disorder of early language delay and cerebral white matter hyperintensities

Q37083438

The essential, nonredundant roles of RIG-I and MDA5 in detecting and controlling West Nile virus infection

Q37252672

Type I interferon-mediated monogenic autoinflammation: The type I interferonopathies, a conceptual overview

Q37415269

Deficiency of melanoma differentiation-associated protein 5 results in exacerbated chronic postviral lung inflammation

Q37688505

Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling

Q37732141

Enteroviruses and type 1 diabetes: towards a better understanding of the relationship.

Q37772438

Update on rhinovirus and coronavirus infections

Q37920800

Infectious pathogens and bronchiolitis outcomes

Q38202199

Sustained activation of interferon regulatory factor 3 during infection by paramyxoviruses requires MDA5.

Q38998010

Influenza: propagation, quantification, and storage

Q39149851

Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha/beta interferon genes by interferon regulatory factors 3 and 7.

Q39455009

Human rhinovirus recognition in non-immune cells is mediated by Toll-like receptors and MDA-5, which trigger a synergetic pro-inflammatory immune response

Q39609118

Differential type I IFN-inducing abilities of wild-type versus vaccine strains of measles virus

Q40065382

Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 2. Explicit Solvent Particle Mesh Ewald

Q40291611

Human complete Stat-1 deficiency is associated with defective type I and II IFN responses in vitro but immunity to some low virulence viruses in vivo

Q40296138

Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity.

Q40318735

The mutation significance cutoff: gene-level thresholds for variant predictions

Q40814517

Clinical application of whole-exome sequencing across clinical indications

Q41075733

Airway Progenitor Clone Formation Is Enhanced by Y-27632-Dependent Changes in the Transcriptome

Q41091063

Enterovirus infection and type 1 diabetes: closing in on a link?

Q41290004

Molecular identification and quantification of human rhinoviruses in respiratory samples

Q41724629

Lentivirus-delivered stable gene silencing by RNAi in primary cells

Q41996459

MDA5 and MAVS mediate type I interferon responses to coxsackie B virus.

Q42109953

Brief Report: IFIH1 Mutation Causes Systemic Lupus Erythematosus With Selective IgA Deficiency.

Q42154554

Growth of human rhinovirus in H1-HeLa cell suspension culture and purification of virions

Q42185718

Development of polyphosphate parameters for use with the AMBER force field.

Q44449257

Efficient gene transfer into rhesus repopulating hematopoietic stem cells using a simian immunodeficiency virus-based lentiviral vector system

Q45674295

Disease burden of the most commonly detected respiratory viruses in hospitalized patients calculated using the disability adjusted life year (DALY) model

Q57769566

Enterovirus antibody titers after IVIG replacement in agammaglobulinemic children

Q73417649

Calcium phosphate transfection

Q80568536

Enterovirus-specific IgG in intravenous immunoglobulin preparations

Q84225534

Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium

Q33747598

Aicardi-Goutières syndrome is caused by IFIH1 mutations.

Q33858615

Improved molecular typing assay for rhinovirus species A, B, and C.

Q33900210

MDA5 and TLR3 initiate pro-inflammatory signaling pathways leading to rhinovirus-induced airways inflammation and hyperresponsiveness

Q33921121

Murine coronavirus induces type I interferon in oligodendrocytes through recognition by RIG-I and MDA5.

Q33990644

Somatic reversion in dedicator of cytokinesis 8 immunodeficiency modulates disease phenotype

Q34042360

Role of double-stranded RNA pattern recognition receptors in rhinovirus-induced airway epithelial cell responses

Q34062072

The common cold

Q34169126

Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells

Q34312954

Guidelines for genetic studies in single patients: lessons from primary immunodeficiencies

Q34375180

Clinical whole-exome sequencing for the diagnosis of mendelian disorders

Q34413680

A specific IFIH1 gain-of-function mutation causes Singleton-Merten syndrome

Q34459602

Identification of a large set of rare complete human knockouts

Q34468556

Infectious disease. Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency

Q34468857

SnIPRE: selection inference using a Poisson random effects model

Q34510133

A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region

Q34525819

Retinoic acid inducible gene-I and mda-5 are involved in influenza A virus-induced expression of antiviral cytokines

Q34541506

RNA sensor-induced type I IFN prevents diabetes caused by a β cell-tropic virus in mice

Q34755163

Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution

Q34943950

High level transient gene expression in human lymphoid cells by SV40 large T antigen boost

Q35011901

Viral infections of the lower respiratory tract: old viruses, new viruses, and the role of diagnosis

Q35019802

Molecular findings among patients referred for clinical whole-exome sequencing

Q35078373

A serpin shapes the extracellular environment to prevent influenza A virus maturation

Q35083702

Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study.

Q35147055

Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5.

Q35239001

Infectivity assays of human rhinovirus-A and -B serotypes

Q35281197

Melanoma differentiation-associated gene 5 is critical for protection against Theiler's virus-induced demyelinating disease

Q35689719

Community Surveillance of Respiratory Viruses Among Families in the Utah Better Identification of Germs-Longitudinal Viral Epidemiology (BIG-LoVE) Study

Q36094237

In Vivo RNAi Screening Identifies MDA5 as a Significant Contributor to the Cellular Defense against Influenza A Virus

Q36100793

Community-acquired pneumonia requiring hospitalization among U.S. children

Q36420016

Genomic Signatures of Selective Pressures and Introgression from Archaic Hominins at Human Innate Immunity Genes

Q36473385

Critical role of MDA5 in the interferon response induced by human metapneumovirus infection in dendritic cells and in vivo

Q36559518

Nonstructural proteins 1 and 2 of respiratory syncytial virus suppress maturation of human dendritic cells

Q36845814

Rational Design of Particle Mesh Ewald Compatible Lennard-Jones Parameters for +2 Metal Cations in Explicit Solvent

Q37058615

P433

issue

P407

language of work or name

English

Q1860

P304

page(s)

1949-1972

P577

publication date

2017-06-12

P1433

published in

Journal of Experimental Medicine

Q3186912

P1476

title

Recurrent rhinovirus infections in a child with inherited MDA5 deficiency

P478

volume

214

Reverse relations

cites work (P2860)

Q59352927	A Balancing Act: MDA5 in Antiviral Immunity and Autoinflammation
Q95604045	A Phased Approach to Resuming Suspended Allergy/Immunology Clinical Services
Q94671992	A global effort to define the human genetics of protective immunity to SARS-CoV-2 infection
Q64450546	Antiviral therapeutic approaches for human rhinovirus infections
Q89467789	Bi-allelic Variants in TKFC Encoding Triokinase/FMN Cyclase Are Associated with Cataracts and Multisystem Disease
Q96034123	Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment
Q97644540	Deciphering the Role of Host Genetics in Susceptibility to Severe COVID-19
Q49906730	Defective RNA sensing by RIG-I in severe influenza virus infection
Q92390237	Efficacy and Adverse Events During Janus Kinase Inhibitor Treatment of SAVI Syndrome
Q64257540	Evaluation of Mannose Binding Lectin Gene Variants in Pediatric Influenza Virus-Related Critical Illness
Q53061634	From clinical observations and molecular dissection to novel therapeutic strategies for primary immunodeficiency disorders.
Q102220455	Host genetic susceptibility to viral infections: the role of type I interferon induction
Q104073833	Host genetics and infectious disease: new tools, insights and translational opportunities
Q47279598	Human genetics of infectious diseases: Unique insights into immunological redundancy
Q89563496	Human genetics of life-threatening influenza pneumonitis
Q54256192	IRF4 haploinsufficiency in a family with Whipple's disease.
Q46263244	Inborn errors of immunity underlying fungal diseases in otherwise healthy individuals
Q98721439	Increased respiratory viral detection and symptom burden among patients with primary antibody deficiency: results from the BIPAD study
Q92494838	Innate immunity in allergy
Q62898063	Interferon-Induced Transmembrane Protein 1 Restricts Replication of Viruses That Enter Cells via the Plasma Membrane
Q90740614	Lessons learned from the study of human inborn errors of innate immunity
Q59353949	Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency
Q112279597	Lung type II alveolar epithelial cells collaborate with CCR2⁺ inflammatory monocytes in host defense against poxvirus infection
Q40100672	PACT Facilitates RNA-Induced Activation of MDA5 by Promoting MDA5 Oligomerization.
Q90288795	Pharmacological modulation of nucleic acid sensors - therapeutic potential and persisting obstacles
Q57459322	Phenome-wide association studies across large population cohorts support drug target validation
Q97067634	Primary Immunodeficiencies With Defects in Innate Immunity: Focus on Orofacial Manifestations
Q90746855	Recent advances in primary immunodeficiency: from molecular diagnosis to treatment
Q92065173	Recent advances in understanding inherited deficiencies in immunity to infections
Q41918099	Recurrent and Prolonged Infections in a Child with a Homozygous IFIH1 Nonsense Mutation
Q97423505	Rhinovirus and Innate Immune Function of Airway Epithelium
Q90362499	Role of CARD Region of MDA5 Gene in Canine Influenza Virus Infection
Q64118246	Role of Type I Interferon (IFN) in the Respiratory Syncytial Virus (RSV) Immune Response and Disease Severity
Q40119340	Severe viral respiratory infections in children with IFIH1 loss-of-function mutations.
Q58795403	The Lung in Primary Immunodeficiencies: New Concepts in Infection and Inflammation
Q61053820	The human CIB1-EVER1-EVER2 complex governs keratinocyte-intrinsic immunity to β-papillomaviruses
Q99371009	The role of Host Genetics in susceptibility to severe viral infections in humans and INSIGHTS into host genetics of severe COVID-19: A systematic review
Q89866823	Women in immunology: 2020 and beyond