HPV8 Field Cancerization in a Transgenic Mouse Model Is due to Lrig1+ Keratinocyte Stem Cell Expansion

scientific article published on 5 June 2017

HPV8 Field Cancerization in a Transgenic Mouse Model Is due to Lrig1+ Keratinocyte Stem Cell Expansion is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.JID.2017.04.039
P932PMC publication ID5613749
P698PubMed publication ID28595997

P50authorMarco De AndreaQ37841149
P2093author name stringGirish K Patel
Marisa Gariglio
Herbert Pfister
Cinzia Borgogna
Sarah Harries
Carlotta Olivero
Simone Lanfredini
Kathryn Powell
Federica Calati
Hiu Kwan Carolyn Tang
Kelli-Jo Davies
P2860cites workE6 and E7 from beta HPV38 cooperate with ultraviolet light in the development of actinic keratosis-like lesions and squamous cell carcinoma in miceQ21089610
p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activitiesQ22003973
Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformisQ24317519
Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescenceQ24670890
p63 regulates proliferation and differentiation of developmentally mature keratinocytesQ24675193
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial developmentQ28587664
Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric originQ33968610
Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendmentsQ34021545
p63 in skin development and ectodermal dysplasiasQ34058121
Aberrations of the tumor suppressor p53 gene and p53 protein in solar keratosis in human skinQ34323726
Markers of epidermal stem cell subpopulations in adult mammalian skinQ34427796
Human papillomavirus-DNA loads in actinic keratoses exceed those in non-melanoma skin cancersQ34429330
p63 identifies keratinocyte stem cellsQ34707172
Characterization of skin lesions induced by skin-tropic α- and β-papillomaviruses in a patient with epidermodysplasia verruciformis.Q35182417
p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53.Q35227440
Frequent clones of p53-mutated keratinocytes in normal human skinQ35940911
The human papillomavirus type 8 E6 protein interferes with NOTCH activation during keratinocyte differentiationQ36760228
Expression of betapapillomavirus oncogenes increases the number of keratinocytes with stem cell-like propertiesQ37254338
Regenerating the skin: a task for the heterogeneous stem cell pool and surrounding nicheQ38142568
Human Beta-papillomavirus infection and keratinocyte carcinomasQ38240647
Beta genus papillomaviruses and skin cancer.Q38365921
Maintaining epithelial stemness with p63.Q38556654
Human papillomavirus infection and induction of neoplasia: a matter of fitnessQ38947845
Characterization of beta papillomavirus E4 expression in tumours from Epidermodysplasia Verruciformis patients and in experimental modelsQ39417822
Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermisQ41390151
α- and β-papillomavirus infection in a young patient with an unclassified primary T-cell immunodeficiency and multiple mucosal and cutaneous lesionsQ42232702
Improved detection reveals active β-papillomavirus infection in skin lesions from kidney transplant recipientsQ42245249
Development of skin tumors in mice transgenic for early genes of human papillomavirus type 8.Q42474839
Stem cell markers (cytokeratin 15, cytokeratin 19 and p63) in in situ and invasive cutaneous epithelial lesionsQ42477268
Down-regulation of p63 is required for epidermal UV-B-induced apoptosisQ42492073
Ras and TGF-β signaling enhance cancer progression by promoting the ΔNp63 transcriptional programQ42498067
DNA repair deficiency leads to susceptibility to develop arsenic-induced premalignant skin lesionsQ42526403
Detection of human papillomavirus DNA in plucked hairs from renal transplant recipients and healthy volunteers.Q42654662
Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermisQ44572857
Primary immunodeficiency diseases: an updateQ48714766
Comprehensive control of human papillomavirus infections and related diseases.Q51856187
Keratinocyte-specific stat3 heterozygosity impairs development of skin tumors in human papillomavirus 8 transgenic mice.Q53294915
β-Papillomavirus Infection and Skin CancerQ56637516
VIGNETTESQ62488693
The human papillomavirus type 8 E2 protein induces skin tumors in transgenic miceQ81052726
Spontaneous tumour development in human papillomavirus type 8 E6 transgenic mice and rapid induction by UV-light exposure and woundingQ84432554
P4510describes a project that usesImageJQ1659584
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectkeratinocyteQ1473931
P304page(s)2208-2216
P577publication date2017-06-05
P1433published inJournal of Investigative DermatologyQ3186921
P1476titleHPV8 Field Cancerization in a Transgenic Mouse Model Is due to Lrig1+ Keratinocyte Stem Cell Expansion
P478volume137

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cites work (P2860)
Q90706027Cancer stem cells in esophageal squamous cell cancer
Q40084064Changing Stem Cell Dynamics during Papillomavirus Infection: Potential Roles for Cellular Plasticity in the Viral Lifecycle and Disease.
Q55054189Cutaneous Papillomaviruses and Non-melanoma Skin Cancer: Causal Agents or Innocent Bystanders?
Q59327096Editorial: Human Papillomaviruses and Polyomaviruses in Skin Cancer
Q52597650HPV-Induced Field Cancerisation: Transformation of Adult Tissue Stem Cell Into Cancer Stem Cell.
Q40045752Immunopathogenesis of HPV-Associated Cancers and Prospects for Immunotherapy
Q54250476Inhibition of TGF-β and NOTCH Signaling by Cutaneous Papillomaviruses.
Q39434895Molecular Mechanisms of Human Papillomavirus Induced Skin Carcinogenesis
Q64256422Mucosal and Cutaneous Human Papillomavirus Infections and Cancer Biology
Q58762026Oral fibropapillomatosis and epidermal hyperplasia of the lip in newborn lambs associated with bovine Deltapapillomavirus
Q64092342The Protein Tyrosine Phosphatase H1 PTPH1 Supports Proliferation of Keratinocytes and is a Target of the Human Papillomavirus Type 8 E6 Oncogene
Q49829456β-HPV Infection Correlates with Early Stages of Carcinogenesis in Skin Tumors and Patient-Derived Xenografts from a Kidney Transplant Recipient Cohort.