Bioactivation of Prodrugs: Structure-Pharmacokinetic Correlations of Benzodiazepine Esters

scientific article published on January 1, 1983

Bioactivation of Prodrugs: Structure-Pharmacokinetic Correlations of Benzodiazepine Esters is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.3109/03602538308991426
P953full work available at URLhttp://www.tandfonline.com/doi/pdf/10.3109/03602538308991426
P698PubMed publication ID6373209

P2093author name stringOtvös L
Maksay G
P2860cites workDrug Metabolism and DispositionQ1261140
Molecular PharmacologyQ1943386
Conversion of N-alkylaminobenzophenones to benzodiazepines in vivoQ28330166
Rm values and structure-activity relationship of benzodiazepinesQ34285383
Water-soluble derivatives of 3-oxy-substituted 1,4-benzodiazepinesQ36513678
Peptido-aminobenzophenones-novel latentiated benzo-1,4-diazepinesQ39172082
Dependence, Tolerance, and Addiction to Benzodiazepines: Clinical and Pharmacokinetic ConsiderationsQ39221869
Cumene hydroperoxide-supported microsomal hydroxylations of warfarin—A probe of cytochrome P-450 multiplicity and specificityQ39225599
In vivo receptor occupation by benzodiazepines and correlation with the pharmacological effectQ39286452
The Benzodiazepine Receptor in Normal and Pathological Human BrainQ40177295
Is stimulation of benzodiazepine receptor binding mediated by a novel GABA receptor?Q40219716
Gaba receptor-mediated modulation of 3H-diazepam binding in rat cortexQ40252343
Stereospecific influence of oxazepam hemisuccinate on cyclic amp accumulation elicited by adenosine in cerebral cortical slicesQ40264961
Prodrugs and site-specific drug deliveryQ40297385
Correlation between benzodiazepine receptor occupation and anticonvulsant effects of diazepamQ40298346
Kinetic considerations relating to the accrual and elimination of drug metabolitesQ41965782
Oxazepam esters. 2. Correlation of hydrophobicity with serum binding, brain penetration, and excretionQ42032422
Parabolic dependence of drug action upon lipophilic character as revealed by a study of hypnoticsQ43433424
Stereospecific benzodiazepine receptor binding by the enantiomers of oxazepam sodium hemisuccinateQ43898694
Chlordiazepoxide metabolites in the rat. Characterization by high resolution mass spectrometryQ44218627
Interactions of benzodiazepines with human serum albumin. Circular dichroism studiesQ44363131
Brain specific benzodiazepine receptorsQ44452528
3-Substituted 1,4-benzodiazepin-2-onesQ45053919
Benzodiazepine receptors in rat brainQ45205253
Benzodiazepine receptor binding in rat spinal cord membranesQ47833327
Stereospecificity of esterases hydrolyzing oxazepam acetateQ48163799
In vitro hydrolysis of oxazepam succinate half-ester by a stereospecific soluble esterase from different animal species.Q48585188
Metabolism of14C-medazepam hydrochloride in dog, rat and manQ48934374
Relationship between the duration of anticonvulsant activity of chlordiazepoxide and systemic levels of the parent compound and its major metabolites in miceQ49065106
Mutagenicity of carbadox and several quinoxaline 1,4-dioxide derivativesQ50220162
Significance of apparent half-lives of a metabolite with a higher elimination rate than its parent drug.Q51862919
Effect of age and sex on disposition of desmethyldiazepam formed from its precursor clorazepate.Q51871267
Comparison of dihydrodiazepam enantiomers: metabolism, serum binding and brain receptor binding.Q51874120
Blood level distribution patterns of diazepam and its major metabolite in man.Q52758504
Quantitative structure-pharmacokinetic relationships derived on antibacterial sulfonamides in rats and its comparison to quantitative structure-activity relationships.Q52761073
Structural parameters in the microsomal hydrolysis of 3-acyloxy-1, 4-benzodiazepines and the multiplicity of the esterases involved.Q52768580
Hansch analysis of the anabolic activities of some nandrolone estersQ53705344
Gas chromatographic degradation of several drugs and their metabolites.Q54270875
Selective antagonists of benzodiazepinesQ59057876
The Correlation of Biological Activity of Plant Growth Regulators and Chloromycetin Derivatives with Hammett Constants and Partition CoefficientsQ63987734
Electron capture and multiple ion detection of benzodiazepine esters in pharmacokinetic studiesQ66697956
Synthesis of some carbon-3 substituted 1,4-benzodiazepin-2-ones and their central effectsQ66944646
Oxazepam esters. 1. Correlation between hydrolysis rates and brain appearance of oxazepamQ66994187
Enzymic Dealkylation of a Substituted Aminoacetamidobenzophenone and Cyclization to the Corresponding Benzodiazepinein vitroQ67012761
3-Onium derivatives of 1,4-benzodiazepin-2-ones with tertiary organic basesQ69784916
The role of cytochrome P-450 and P-448 in drug and steroid hydroxylationsQ70056786
Prazepam metabolism in vitroQ70340488
Analytical and pharmacokinetic studies on the optic isomers of oxazepam succinate half-esterQ70448305
Oxazepam esters. 3. Intrinsic activity, selectivity, and prodrug effectQ70801057
Effects of enantiomers of oxazepam sodium hemisuccinate on water intake and antagonism of picrotoxin- or naloxone-induced suppression of drinking by chlordiazepoxide in the ratQ71339215
Relationship between camazepam, N-methyl-oxazepam and oxazepam brain concentrations and antileptazol effect in the ratQ72499160
ABSORPTION, METABOLISM, AND EXCRETION OF OXAZEPAM AND ITS SUCCINATE HALF-ESTERQ77166825
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectpharmacokineticsQ323936
P304page(s)1165-1192
P577publication date1983-01-01
P1433published inDrug Metabolism ReviewsQ5308857
P1476titleBioactivation of prodrugs: structure-pharmacokinetic correlations of benzodiazepine esters
Bioactivation of Prodrugs: Structure-Pharmacokinetic Correlations of Benzodiazepine Esters
P478volume14

Reverse relations

cites work (P2860)
Q43934552Enantioselective hydrolysis of oxazepam 3-acetate by esterases in human and rat liver microsomes and rat brain S9 fraction
Q39642115Possible physiological roles of carboxylic ester hydrolases
Q48694611Structure-metabolism relationships in the hydrolysis of nicotinate esters by rat liver and brain subcellular fractions

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