Class A scavenger receptor-mediated macrophage adhesion requires coupling of calcium-independent phospholipase A(2) and 12/15-lipoxygenase to Rac and Cdc42 activation.

scientific article published on 15 September 2007

Class A scavenger receptor-mediated macrophage adhesion requires coupling of calcium-independent phospholipase A(2) and 12/15-lipoxygenase to Rac and Cdc42 activation. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M704133200
P932PMC publication ID2080787
P698PubMed publication ID17873277

P50authorSteven R PostQ59695005
P2093author name stringJohn Turk
Ming C Gong
Dejan M Nikolic
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12/15-lipoxygenase translocation enhances site-specific actin polymerization in macrophages phagocytosing apoptotic cellsQ24291036
Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activitiesQ24303914
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Pancreatic islets express a Ca2+-independent phospholipase A2 enzyme that contains a repeated structural motif homologous to the integral membrane protein binding domain of ankyrinQ28577938
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Selective adhesion of macrophages to denatured forms of type I collagen is mediated by scavenger receptorsQ28647589
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GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factorsQ29547630
Activation of Rac and Cdc42 by integrins mediates cell spreadingQ29616113
Increased Production of 12/15 Lipoxygenase Eicosanoids Accelerates Monocyte/Endothelial Interactions in Diabetic db/db MiceQ30310826
12/15-lipoxygenase regulates intercellular adhesion molecule-1 expression and monocyte adhesion to endothelium through activation of RhoA and nuclear factor-kappaB.Q30438056
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Male mice that do not express group VIA phospholipase A2 produce spermatozoa with impaired motility and have greatly reduced fertility.Q37070443
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Class A scavenger receptor-mediated cell adhesion requires the sequential activation of Lyn and PI3-kinase.Q40189737
Genetic and pharmacologic evidence that calcium-independent phospholipase A2beta regulates virus-induced inducible nitric-oxide synthase expression by macrophagesQ40411579
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Class A scavenger receptors mediate cell adhesion via activation of G(i/o) and formation of focal adhesion complexesQ40694093
Signaling pathways initiated in macrophages after engagement of type A scavenger receptorsQ40795198
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The role of prostaglandin E2 and nitric oxide in cell death in J774 murine macrophagesQ41024024
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Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrilsQ41173971
Rac mediates growth factor-induced arachidonic acid release.Q41334607
The processing of ligands by the class A scavenger receptor is dependent on signal information located in the cytoplasmic domainQ41706870
Identity between the Ca2+-independent phospholipase A2 enzymes from P388D1 macrophages and Chinese hamster ovary cellsQ42436218
Expression of LDL receptor, VLDL receptor, LDL receptor-related protein, and scavenger receptor in rabbit atherosclerotic lesions: marked induction of scavenger receptor and VLDL receptor expression during lesion developmentQ42453290
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Pathological roles of advanced glycation end product receptors SR-A and CD36.Q42812060
Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein e-deficient miceQ43600849
Secreted forms of the amyloid-beta precursor protein are ligands for the class A scavenger receptor.Q43627899
Macrophage-specific expression of class A scavenger receptors enhances granuloma formation in the absence of increased lipid deposition.Q43664793
NSAIDs inhibit alpha V beta 3 integrin-mediated and Cdc42/Rac-dependent endothelial-cell spreading, migration and angiogenesis.Q43726776
Protein kinase Calpha-dependent increase in Ca2+-independent phospholipase A2 in membranes and arachidonic acid liberation in zymosan-stimulated macrophage-like P388D1 cellsQ44047246
The class A scavenger receptor binds to proteoglycans and mediates adhesion of macrophages to the extracellular matrix.Q44253553
Cigarette smoke triggers macrophage adhesion and activation: role of lipid peroxidation products and scavenger receptorQ44635302
Expression of class A scavenger receptor is enhanced by high glucose in vitro and under diabetic conditions in vivo: one mechanism for an increased rate of atherosclerosis in diabetesQ45158469
Biologically active lipids are regulators of Rac.GDI complexationQ46250677
Enhanced proatherogenic responses in macrophages and vascular smooth muscle cells derived from diabetic db/db miceQ47590797
A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infectionQ59068486
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Suicide inhibition of canine myocardial cytosolic calcium-independent phospholipase A2. Mechanism-based discrimination between calcium-dependent and -independent phospholipases A2Q70139295
Role of PGI2 and epoxyeicosatrienoic acids in relaxation of bovine coronary arteries to arachidonic acidQ70595499
Transcellular eicosanoid synthesis in cocultures of alveolar epithelial cells and macrophagesQ70729038
Macrophages adhere to glucose-modified basement membrane collagen IV via their scavenger receptorsQ72332014
Macrophage arachidonate release via both the cytosolic Ca(2+)-dependent and -independent phospholipases is necessary for cell spreadingQ73066778
Prostaglandin E2 production dependent upon cyclooxygenase-1 and cyclooxygenase-2 and its contradictory modulation by auranofin in rat peritoneal macrophagesQ73341907
Regulation of acetylated low density lipoprotein uptake in macrophages by pertussis toxin-sensitive G proteinsQ73728427
Involvement of calcium and arachidonate metabolism in acetylated-low-density-lipoprotein-stimulated tumor-necrosis-factor-alpha production by rat peritoneal macrophagesQ74523714
The role of scavenger receptor class A in the adhesion of cells is dependent on cell type and cellular activation stateQ77943999
Involvement of group VI Ca2+-independent phospholipase A2 in protein kinase C-dependent arachidonic acid liberation in zymosan-stimulated macrophage-like P388D1 cellsQ77955228
Macrophage scavenger receptor-a-deficient mice are resistant against diabetic nephropathy through amelioration of microinflammationQ79678212
P433issue46
P407language of work or nameEnglishQ1860
P304page(s)33405-33411
P577publication date2007-09-15
P1433published inJournal of Biological ChemistryQ867727
P1476titleClass A scavenger receptor-mediated macrophage adhesion requires coupling of calcium-independent phospholipase A(2) and 12/15-lipoxygenase to Rac and Cdc42 activation
P478volume282

Reverse relations

cites work (P2860)
Q35423551Analysis of two major intracellular phospholipases A(2) (PLA(2)) in mast cells reveals crucial contribution of cytosolic PLA(2)α, not Ca(2+)-independent PLA(2)β, to lipid mobilization in proximal mast cells and distal fibroblasts
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Q41955516Endothelial cell prostaglandin I(2) and platelet-activating factor production are markedly attenuated in the calcium-independent phospholipase A(2)beta knockout mouse
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Q39610182bFGF-mediated redox activation of the PI3K/Akt pathway in retinal photoreceptor cells
Q58609392iPLAβ and its role in male fertility, neurological disorders, metabolic disorders, and inflammation

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