Mechanical coupling via the membrane fusion SNARE protein syntaxin 1A: a molecular dynamics study

scientific article published on March 2003

Mechanical coupling via the membrane fusion SNARE protein syntaxin 1A: a molecular dynamics study is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0006-3495(03)74965-0
P932PMC publication ID1302726
P698PubMed publication ID12609859
P5875ResearchGate publication ID10879807

P2093author name stringHelmut Grubmüller
Volker Knecht
P2860cites workOptimization by Simulated AnnealingQ25939004
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolutionQ27765619
Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical featuresQ27860675
MOLMOL: a program for display and analysis of macromolecular structuresQ27860873
SNAP receptors implicated in vesicle targeting and fusionQ28131653
SNAREpins: minimal machinery for membrane fusionQ28131697
Stereochemistry of polypeptide chain configurationsQ28190300
Cholesterol organization in membranes at low concentrations: effects of curvature stress and membrane thicknessQ28359621
SNAREs are concentrated in cholesterol-dependent clusters that define docking and fusion sites for exocytosisQ28364095
Reconstituted syntaxin1a/SNAP25 interacts with negatively charged lipids as measured by lateral diffusion in planar supported bilayersQ28367662
Membrane fusion and exocytosisQ29614426
Vesicle fusion from yeast to manQ29618200
SNARE-mediated membrane fusionQ29619234
Characterization of the thermotropic behavior and lateral organization of lipid-peptide mixtures by a combined experimental and theoretical approach: effects of hydrophobic mismatch and role of flanking residuesQ30447448
Intracellular membrane fusion: SNAREs only?Q33712498
Protein-protein interactions in neurotransmitter releaseQ33843204
Structural insights into the molecular mechanism of calcium-dependent vesicle-membrane fusionQ33942089
Protein-protein interactions in intracellular membrane fusion.Q34103402
Molecular determinants of exocytosisQ34505449
SNARE proteins are highly enriched in lipid rafts in PC12 cells: implications for the spatial control of exocytosis.Q35888471
The molecular machinery for secretion is conserved from yeast to neuronsQ36184412
A quantitative model for membrane fusion based on low-energy intermediatesQ36300310
Close is not enough: SNARE-dependent membrane fusion requires an active mechanism that transduces force to membrane anchorsQ36342484
Three SNARE complexes cooperate to mediate membrane fusionQ36538800
Content mixing and membrane integrity during membrane fusion driven by pairing of isolated v-SNAREs and t-SNAREs.Q36546123
Organization of model helical peptides in lipid bilayers: insight into the behavior of single-span protein transmembrane domainsQ40210213
Bending membranes to the task: structural intermediates in bilayer fusionQ40927409
Neurotransmitter release - four years of SNARE complexesQ41541527
SNAREs and NSF in targeted membrane fusionQ41566661
Molecular dynamics simulations of a fluid bilayer of dipalmitoylphosphatidylcholine at full hydration, constant pressure, and constant temperatureQ41775672
Transmembrane helix structure, dynamics, and interactions: multi-nanosecond molecular dynamics simulationsQ42928688
Distinct domains of syntaxin are required for synaptic vesicle fusion complex formation and dissociationQ46887153
Calcium can disrupt the SNARE protein complex on sea urchin egg secretory vesicles without irreversibly blocking fusionQ48004308
Dimerization of the synaptic vesicle protein synaptobrevin (vesicle-associated membrane protein) II depends on specific residues within the transmembrane segment.Q48593040
The transmembrane domain of syntaxin 1A is critical for cytoplasmic domain protein-protein interactions.Q48933075
Ca2+ regulates the interaction between synaptotagmin and syntaxin 1.Q52508040
Lipid vesicles and membrane fusionQ56386319
Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systemsQ56750591
Probable Inference, the Law of Succession, and Statistical InferenceQ57076228
Molecular dynamics with coupling to an external bathQ57569060
Membrane fusionQ57978971
Defining the functions of trans-SNARE pairsQ59079276
The length of the flexible SNAREpin juxtamembrane region is a critical determinant of SNARE-dependent fusionQ73075597
Transmembrane orientation of hydrophobic alpha-helices is regulated both by the relationship of helix length to bilayer thickness and by the cholesterol concentrationQ73581658
A conserved membrane-spanning amino acid motif drives homomeric and supports heteromeric assembly of presynaptic SNARE proteinsQ73675955
[Molecular dynamics of bending fluctuations in the protein secondary structures]Q74311201
Peptide mimics of SNARE transmembrane segments drive membrane fusion depending on their conformational plasticityQ74414914
The membrane-dipped neuronal SNARE complex: a site-directed spin labeling electron paramagnetic resonance studyQ74464849
Hydrophobic mismatch between proteins and lipids in membranesQ77521434
P433issue3
P407language of work or nameEnglishQ1860
P1104number of pages21
P304page(s)1527-1547
P577publication date2003-03-01
P1433published inBiophysical JournalQ2032955
P1476titleMechanical coupling via the membrane fusion SNARE protein syntaxin 1A: a molecular dynamics study
P478volume84

Reverse relations

cites work (P2860)
Q39276813All-atom and coarse-grained simulations of the forced unfolding pathways of the SNARE complex.
Q34172968Caught in the act: visualization of SNARE-mediated fusion events in molecular detail
Q36431491Defending the zygote: search for the ancestral animal block to polyspermy
Q33603031Dilation of fusion pores by crowding of SNARE proteins
Q81376037Energetics and dynamics of SNAREpin folding across lipid bilayers
Q45141553Entropic forces drive self-organization and membrane fusion by SNARE proteins.
Q36426352Flavin Binding to the Deca-heme Cytochrome MtrC: Insights from Computational Molecular Simulation
Q36628886Goliath family E3 ligases regulate the recycling endosome pathway via VAMP3 ubiquitylation.
Q58374211Interbilayer repulsion forces between tension-free lipid bilayers from simulation
Q35696780Lipid rafts and the regulation of exocytosis
Q36901510Mechanics of membrane fusion
Q33770433Membrane Fusion Involved in Neurotransmission: Glimpse from Electron Microscope and Molecular Simulation
Q85392206Membrane-proximal tryptophans of synaptobrevin II stabilize priming of secretory vesicles
Q36119093Membranes of the world unite!
Q38165074Milk secretion: The role of SNARE proteins.
Q42773706Molecular dynamics simulations of lipid vesicle fusion in atomic detail
Q26849286Molecular machines governing exocytosis of synaptic vesicles
Q36292164Phosphatidylinositol 4,5-biphosphate (PIP(2)) lipids regulate the phosphorylation of syntaxin N-terminus by modulating both its position and local structure
Q38879619Probing the structural dynamics of the SNARE recycling machine based on coarse-grained modeling
Q42654259Regulation of Exocytotic Fusion Pores by SNARE Protein Transmembrane Domains
Q57802827SNARE-mediated membrane fusion is a two-stage process driven by entropic forces
Q29547230SNAREs--engines for membrane fusion
Q33967718Structural insights into the SNARE mechanism
Q39121037The Multifaceted Role of SNARE Proteins in Membrane Fusion.
Q27931683The polybasic juxtamembrane region of Sso1p is required for SNARE function in vivo

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