Stereoselectivity in metabolism of ifosfamide by CYP3A4 and CYP2B6.

scientific article published on May 2006

Stereoselectivity in metabolism of ifosfamide by CYP3A4 and CYP2B6. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1080/00498250600598486
P698PubMed publication ID16854777

P2093author name stringP A Philip
H Lu
J J Wang
K K Chan
P2860cites workQuinidine and the identification of drugs whose elimination is impaired in subjects classified as poor metabolizers of debrisoquineQ34448258
Cytochromes P-450 in rats: structures, functions, properties and relevant human formsQ36255451
Ifosfamide--pharmacology, safety and therapeutic potentialQ39827086
Enantioselective metabolism and cytotoxicity of R-ifosfamide and S-ifosfamide by tumor cell-expressed cytochromes P450.Q40416532
V79 Chinese hamster cells genetically engineered for cytochrome P450 and their use in mutagenicity and metabolism studiesQ40778289
Use of V79 cells with stably transfected cytochrome P450 cDNAs in studying the metabolism and effects of cytotoxic drugsQ40977217
Identification of the major human hepatic cytochrome P450 involved in activation and N-dechloroethylation of ifosfamideQ42285396
Activation of the anticancer prodrugs cyclophosphamide and ifosfamide: identification of cytochrome P450 2B enzymes and site-specific mutants with improved enzyme kineticsQ44854955
Analysis of ifosfamide, 4-hydroxyifosfamide, N2-dechloroethylifosfamide, N3-dechloroethylifosfamide and iphosphoramide mustard in plasma by gas chromatography-mass spectrometryQ46281480
Directed evolution of mammalian cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several substrates, including the anticancer prodrugs cyclophosphamide and ifosfamideQ46387102
Contribution of CYP3A5 to hepatic and renal ifosfamide N-dechloroethylationQ46430447
Activation of the anti-cancer drug ifosphamide by rat liver microsomal P450 enzymesQ58483760
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectifosfamideQ418560
stereoselectivityQ903429
P304page(s)367-385
P577publication date2006-05-01
P1433published inXenobioticaQ1360678
P1476titleStereoselectivity in metabolism of ifosfamide by CYP3A4 and CYP2B6.
P478volume36

Reverse relations

cites work (P2860)
Q88658051Common Polymorphisms of CYP2B6 Influence Stereoselective Bupropion Disposition
Q30520640Contributions of human enzymes in carcinogen metabolism
Q47594127Stereochemical considerations in pharmacokinetic processes of representative antineoplastic agents
Q36788391Stereoselectivity in drug metabolism
Q47951404Therapeutic options for patients with lymphoma and liver dysfunction or failure during mechlorethamine shortage

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