Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase

scientific article published on 17 March 2006

Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M506431200
P698PubMed publication ID16547010

P2093author name stringMasashi Miyano
Tsuyoshi Inoue
Kosuke Aritake
Yoshihiro Urade
Yuji Kado
P2860cites workProstaglandin D synthase gene is involved in the regulation of non-rapid eye movement sleepQ22253983
Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2Q24290855
Mechanism of metal activation of human hematopoietic prostaglandin D synthaseQ24297334
5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytesQ24320095
Prostaglandin D synthase in human megakaryoblastic cellsQ24322892
Improved methods for building protein models in electron density maps and the location of errors in these modelsQ26776980
Crystallography & NMR System: A New Software Suite for Macromolecular Structure DeterminationQ26778405
MOLSCRIPT: a program to produce both detailed and schematic plots of protein structuresQ26778412
Cloning and crystal structure of hematopoietic prostaglandin D synthaseQ27745550
Raster3D Version 2.0. A program for photorealistic molecular graphicsQ27860485
Activation of the prostaglandin D2 receptor DP2/CRTH2 increases allergic inflammation in mouseQ28238317
Hydrogen bonds with pi-acceptors in proteins: frequencies and role in stabilizing local 3D structuresQ31816290
Prostaglandin D synthase: structure and functionQ33834101
Hematopoietic prostaglandin D synthaseQ34219405
First determination of the inhibitor complex structure of human hematopoietic prostaglandin D synthase.Q34316991
Cyclooxygenase 2-implications on maintenance of gastric mucosal integrity and ulcer healing: controversial issues and perspectivesQ34340684
Induction of hematopoietic prostaglandin D synthase in human megakaryocytic cells by phorbol esterQ34451773
Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient miceQ34852356
Impaired locomotor activity and exploratory behavior in mice lacking histamine H1 receptorsQ36692674
Structural basis of hematopoietic prostaglandin D synthase activity elucidated by site-directed mutagenesisQ38311013
Protein kinase C activates human lipocalin-type prostaglandin D synthase gene expression through de-repression of notch-HES signaling and enhancement of AP-2 beta function in brain-derived TE671 cells.Q40451710
RasGRP4 regulates the expression of prostaglandin D2 in human and rat mast cell linesQ40682143
Coupling between cyclooxygenase, terminal prostanoid synthase, and phospholipase A2.Q40797404
Induction of cyclooxygenase-1 in a human megakaryoblastic cell line (CMK) differentiated by phorbol esterQ41134952
Characterization of the unfolding process of lipocalin-type prostaglandin D synthaseQ44222490
Prostaglandins inhibit 5-lipoxygenase-activating protein expression and leukotriene B4 production from dendritic cells via an IL-10-dependent mechanismQ44259074
Chemoattractant receptor-homologous molecule expressed on Th2 cells activation in vivo increases blood leukocyte counts and its blockade abrogates 13,14-dihydro-15-keto-prostaglandin D2-induced eosinophilia in ratsQ44585538
COX-2 inhibitors--lessons in drug safetyQ45267551
Biochemical characterization of mouse microsomal prostaglandin E synthase-1 and its colocalization with cyclooxygenase-2 in peritoneal macrophagesQ46236501
Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3.Q46418233
Pharmacological studies on the novel antiallergic drug HQL-79: I. Antiallergic and antiasthmatic effects in various experimental modelsQ46690846
Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antiasthmatic effectsQ46834818
Expression of prostaglandin D synthase and the prostaglandin D2 receptors DP and CRTH2 in human nasal mucosaQ47425685
Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher.Q48577686
Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthaseQ56592820
Identification and isolation of a membrane protein necessary for leukotriene productionQ59059824
P433issue22
P407language of work or nameEnglishQ1860
P1104number of pages10
P304page(s)15277-15286
P577publication date2006-03-17
P1433published inJournal of Biological ChemistryQ867727
P1476titleStructural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase
P478volume281

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cites work (P2860)
Q42829127A novel pathway to enhance adipocyte differentiation of 3T3-L1 cells by up-regulation of lipocalin-type prostaglandin D synthase mediated by liver X receptor-activated sterol regulatory element-binding protein-1c
Q42576987An interaction between L-prostaglandin D synthase and arrestin increases PGD2 production
Q42581400Biochemical, functional, and pharmacological characterization of AT-56, an orally active and selective inhibitor of lipocalin-type prostaglandin D synthase
Q33528245Comparison of PGH2 binding site in prostaglandin synthases.
Q38485579Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS)
Q24630614Enzymes of the cyclooxygenase pathways of prostanoid biosynthesis
Q39201570Eosinophils in human oral squamous carcinoma; role of prostaglandin D2.
Q44548551Expression and detrimental role of hematopoietic prostaglandin D synthase in spinal cord contusion injury
Q35872751Hematopoetic prostaglandin D synthase: an ESR1-dependent oviductal epithelial cell synthase
Q84879543Hematopoietic prostaglandin D synthase (H-Pgds) is expressed in the early embryonic gonad and participates to the initial nuclear translocation of the SOX9 protein
Q34633614Hematopoietic-Prostaglandin D2 synthase through PGD2 production is involved in the adult ovarian physiology.
Q33967499High-quality crystals of human haematopoietic prostaglandin D synthase with novel inhibitors
Q34416262Improvement in the quality of hematopoietic prostaglandin D synthase crystals in a microgravity environment
Q37164193Inhibition of prostaglandin D synthase suppresses muscular necrosis
Q57284969L-Pgds but not H-Pgds deletion causes hypertension and accelerates thrombogenesis in mice
Q40601963Mast cell-derived prostaglandin D2 controls hyaluronan synthesis in human orbital fibroblasts via DP1 activation: implications for thyroid eye disease
Q41041451Mast cells contribute to double-stranded RNA-induced augmentation of airway eosinophilia in a murine model of asthma
Q47777584Niacin Promotes Cardiac Healing after Myocardial Infarction through Activation of the Myeloid Prostaglandin D2 Receptor Subtype 1.
Q45961332Obesity-induced changes in lipid mediators persist after weight loss.
Q36076180PGD synthase and PGD2 in immune resposne
Q36662906PGD(2) DP1 receptor protects brain from ischemia-reperfusion injury.
Q28731227PGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2
Q39449759Prevention of paraquat-induced apoptosis in human neuronal SH-SY5Y cells by lipocalin-type prostaglandin D synthase
Q43171502Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo.
Q48577686Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher.
Q48156771Prostaglandins D2 and E2 have opposite effects on alveolar macrophages infected with Histoplasma capsulatum.
Q41050351Prostaglandins and Their Receptors in Eosinophil Function and As Therapeutic Targets.
Q35173433Selenium levels affect the IL-4-induced expression of alternative activation markers in murine macrophages
Q37855791Sigma-class glutathione transferases.
Q27643949Structural Basis of the Catalytic Mechanism Operating in Open-Closed Conformers of Lipocalin Type Prostaglandin D Synthase
Q41955640Subchronic infusion of the product of inflammation prostaglandin J2 models sporadic Parkinson's disease in mice
Q30486745The Concise Guide to PHARMACOLOGY 2013/14: enzymes.
Q60687194The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages
Q92941365Therapeutic Potential of Hematopoietic Prostaglandin D2 Synthase in Allergic Inflammation
Q30864246Virtual fragment screening: an exploration of various docking and scoring protocols for fragments using Glide
Q34368348Virtual fragment screening: exploration of MM-PBSA re-scoring

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