HOTAIR Epigenetically Modulates PTEN Expression via MicroRNA-29b: A Novel Mechanism in Regulation of Liver Fibrosis

scientific article published on 4 January 2017

HOTAIR Epigenetically Modulates PTEN Expression via MicroRNA-29b: A Novel Mechanism in Regulation of Liver Fibrosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YMTHE.2016.10.015
P932PMC publication ID5363197
P698PubMed publication ID28129115

P2093author name stringFujun Yu
Bicheng Chen
Jianjian Zheng
Peihong Dong
P2860cites workMicroRNA-153 promotes Wnt/β-catenin activation in hepatocellular carcinoma through suppression of WWOX.Q38906745
Hepatic stellate cell is activated by microRNA-181b via PTEN/Akt pathway.Q38963643
Activation of hepatic stellate cells is suppressed by microRNA-150.Q39162909
DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in ratsQ39307024
Role of PTEN promoter methylation in tamoxifen-resistant breast cancer cellsQ39618112
Epigenetic silencing of O6-methylguanine DNA methyltransferase gene in NiS-transformed cellsQ40023334
Long non-coding RNA APTR promotes the activation of hepatic stellate cells and the progression of liver fibrosisQ41185063
Association of large noncoding RNA HOTAIR expression and its downstream intergenic CpG island methylation with survival in breast cancerQ43513311
Long intergenic noncoding RNA HOTAIR is overexpressed and regulates PTEN methylation in laryngeal squamous cell carcinoma.Q45938250
Over-expressed microRNA-27a and 27b influence fat accumulation and cell proliferation during rat hepatic stellate cell activationQ46137385
Curcumin up-regulates phosphatase and tensin homologue deleted on chromosome 10 through microRNA-mediated control of DNA methylation--a novel mechanism suppressing liver fibrosisQ46181877
Suppression of hepatic stellate cell activation by microRNA-29b.Q54571179
Hepatocytes induce functional activation of naive CD8+ T lymphocytes but fail to promote survivalQ74251688
Inhibitory effects of long noncoding RNA MEG3 on hepatic stellate cells activation and liver fibrogenesisQ85274272
Isolation and culture of hepatic stellate cells from mouse liverQ87034558
A long noncoding RNA activated by TGF-β promotes the invasion-metastasis cascade in hepatocellular carcinomaQ87757619
MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3BQ24564757
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasisQ24607308
Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expressionQ24654249
Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAsQ24673619
Suppression of type I collagen production by microRNA-29b in cultured human stellate cellsQ28117752
Analyzing real-time PCR data by the comparative C(T) methodQ28131831
Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liverQ29616840
Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA.Q33269991
Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancerQ33613022
HOTAIR lifts noncoding RNAs to new levelsQ34004919
Hepatocyte growth factor (HGF) inhibits collagen I and IV synthesis in hepatic stellate cells by miRNA-29 inductionQ34023700
Inhibition of phosphatidylinositol 3-kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosisQ34033114
Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantationQ34165090
Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway.Q34299086
Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundanceQ34418649
Cyclosporine A and tacrolimus inhibit bladder cancer growth through down-regulation of NFATc1.Q35176376
microRNA-29b prevents liver fibrosis by attenuating hepatic stellate cell activation and inducing apoptosis through targeting PI3K/AKT pathway.Q35740215
Pseudogene INTS6P1 regulates its cognate gene INTS6 through competitive binding of miR-17-5p in hepatocellular carcinomaQ35742379
Cytokines and STATs in Liver FibrosisQ35867085
Long noncoding RNA FER1L4 suppresses cancer cell growth by acting as a competing endogenous RNA and regulating PTEN expressionQ35996533
Long Non-coding RNA Growth Arrest-specific Transcript 5 (GAS5) Inhibits Liver Fibrogenesis through a Mechanism of Competing Endogenous RNA.Q36301298
HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer.Q36357062
MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1.Q37262433
MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell deathQ37287182
Long non-coding RNA Malat1 promotes gallbladder cancer development by acting as a molecular sponge to regulate miR-206Q37437323
The tumor suppressor protein PTEN inhibits rat hepatic stellate cell activationQ37465437
The potential of microRNAs in liver fibrosisQ38033924
Long non-coding RNAs: a new frontier in the study of human diseasesQ38116266
Long non-coding RNA HOTAIR modulates c-KIT expression through sponging miR-193a in acute myeloid leukemiaQ38874356
MicroRNA-17-5p activates hepatic stellate cells through targeting of Smad7.Q38881975
P433issue1
P304page(s)205-217
P577publication date2017-01-04
P1433published inMolecular TherapyQ15762400
P1476titleHOTAIR Epigenetically Modulates PTEN Expression via MicroRNA-29b: A Novel Mechanism in Regulation of Liver Fibrosis
P478volume25

Reverse relations

cites work (P2860)
Q57189797Adiponectin inhibits hepatic stellate cell activation by targeting the PTEN/AKT pathway
Q90148665Antiliver Fibrosis Screening of Active Ingredients from Apium graveolens L. Seeds via GC-TOF-MS and UHPLC-MS/MS
Q92425926CircMTO1 inhibits liver fibrosis via regulation of miR-17-5p and Smad7
Q98771725Circular RNA cMTO1 Promotes PTEN Expression Through Sponging miR-181b-5p in Liver Fibrosis
Q64070928Di-n-butyl phthalate epigenetically induces reproductive toxicity via the PTEN/AKT pathway
Q47157566Epigenetic reprogramming in liver fibrosis and cancer
Q99567318Investigating the correlation between DNA methylation and immune‑associated genes of lung adenocarcinoma based on a competing endogenous RNA network
Q92134325Lnc-TCL6 is a potential biomarker for early diagnosis and grade in liver-cirrhosis patients
Q47107587Lnc2Meth: a manually curated database of regulatory relationships between long non-coding RNAs and DNA methylation associated with human disease
Q57035120LncRNA-MEG3 inhibits activation of hepatic stellate cells through SMO protein and miR-212
Q90131299Long Noncoding RNA HOTAIR Promotes Endometrial Carcinoma Cell Proliferation by Binding to PTEN via the Activating Phosphatidylinositol 3-Kinase/Akt Signaling Pathway
Q91688401Long noncoding RNA HOTAIR is upregulated in an aggressive subgroup of gastrointestinal stromal tumors (GIST) and mediates the establishment of gene-specific DNA methylation patterns
Q47951358Long noncoding RNA: a new contributor and potential therapeutic target in fibrosis
Q91610556Loss of lncRNA-SNHG7 Promotes the Suppression of Hepatic Stellate Cell Activation via miR-378a-3p and DVL2
Q46248338Rainbow trout exposed to benzo[a]pyrene yields conserved microRNA binding sites in DNA methyltransferases across 500 million years of evolution
Q58754551Regulation of PTEN expression by noncoding RNAs
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Q59791075The roles of lncRNA in hepatic fibrosis
Q98778873miR-29b enhances the proliferation and migration of bone marrow mesenchymal stem cells in rats with castration-induced osteoporosis through the PI3K/AKT and TGF-β/Smad signaling pathways

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