Design, Synthesis, and Antimicrobial Evaluation of a Novel Bone-Targeting Bisphosphonate-Ciprofloxacin Conjugate for the Treatment of Osteomyelitis Biofilms.

scientific article published on 25 January 2017

Design, Synthesis, and Antimicrobial Evaluation of a Novel Bone-Targeting Bisphosphonate-Ciprofloxacin Conjugate for the Treatment of Osteomyelitis Biofilms. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/ACS.JMEDCHEM.6B01615
P932PMC publication ID5812453
P698PubMed publication ID28121436

P50authorParish P. SedghizadehQ39187404
Marzenna BartoszewiczQ59687345
Robert Graham G RussellQ67903135
Patrycja SzymczykQ85263743
Keivan SadrerafiQ86934843
Monika OleksyQ88664847
P2093author name stringCharles E McKenna
Frank H Ebetino
Jeffrey D Neighbors
Mark W Lundy
Shuting Sun
Eric Richard
Neema Bakhshalian
Adam F Junka
Susan Mahabady
Natalia Tjokro
P2860cites workOsteomyelitisQ33205211
Fluoroquinolone-gyrase-DNA complexes: two modes of drug bindingQ33556083
Development of an animal model for Aggregatibacter actinomycetemcomitans biofilm-mediated oral osteolytic infection: a preliminary studyQ33790249
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Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy.Q34009569
Quinolones: a comprehensive reviewQ34115365
Drying of organic solvents: quantitative evaluation of the efficiency of several desiccants.Q34143552
pH-triggered intracellular release from actively targeting polymer micellesQ34627898
Organic carbamates in drug design and medicinal chemistryQ35365543
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Bisphosphonate uptake in areas of tooth extraction or periapical diseaseQ35755688
Chronic osteomyelitis increases long-term mortality risk in the elderly: a nationwide population-based cohort study.Q35974401
Biofilm bacteria: formation and comparative susceptibility to antibioticsQ36500989
Population pharmacokinetic and pharmacodynamic modeling for assessing risk of bisphosphonate-related osteonecrosis of the jaw.Q36532868
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Perturbation of the indigenous rat oral microbiome by ciprofloxacin dosingQ37157745
Aggregatibacter actinomycetemcomitans biofilm killing by a targeted ciprofloxacin prodrugQ37281537
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Oral antibiotic treatment of staphylococcal bone and joint infections in adultsQ38144837
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Local antibiotic delivery systems in diabetic foot osteomyelitis: time for one step beyond?Q38325417
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Understanding osteomyelitis and its treatment through local drug delivery systemQ38969920
Hot melt poly-ε-caprolactone/poloxamine implantable matrices for sustained delivery of ciprofloxacinQ39411105
Ciprofloxacin concentrations in bone and muscle after oral dosingQ39850877
Linking bisphosphonates to the free amino groups in fluoroquinolones: preparation of osteotropic prodrugs for the prevention of osteomyelitis.Q39932880
Bisphosphonates: a review of their pharmacokinetic propertiesQ41132404
Microbial biofilms are able to destroy hydroxyapatite in the absence of host immunity in vitro.Q41579307
Synthesis and in vitro evaluation of bisphosphonated glycopeptide prodrugs for the treatment of osteomyelitis.Q43185478
Design, synthesis, and biological evaluation of novel estradiol-bisphosphonate conjugates as bone-specific estrogens.Q43195387
Osteoadsorptive bisphosphonate derivatives of fluoroquinolone antibacterialsQ43996444
Bisphosphonated fluoroquinolone esters as osteotropic prodrugs for the prevention of osteomyelitisQ44454686
Bisphosphonate-ciprofloxacin bound to Skelite is a prototype for enhancing experimental local antibiotic delivery to injured boneQ45078826
Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses.Q51777217
Antibiotic susceptibility assay for Staphylococcus aureus in biofilms developed in vitroQ78165206
Comparative assessment of the antimicrobial susceptibility of Staphylococcus aureus isolates from bovine mastitis in biofilm versus planktonic cultureQ80162323
Biofilms and chronic infectionsQ81433584
Synthesis of osteotropic hydroxybisphosphonate derivatives of fluoroquinolone antibacterialsQ82554528
Design and synthesis of novel bone-targeting dual-action pro-drugs for the treatment and reversal of osteoporosisQ83461788
Improving bioscience research reporting: the ARRIVE guidelines for reporting animal researchQ83572665
Limb amputation and prosthesisQ87306383
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectbiofilmQ467410
osteomyelitisQ938983
P304page(s)2326-2343
P577publication date2017-02-13
P1433published inJournal of Medicinal ChemistryQ900316
P1476titleDesign, Synthesis, and Antimicrobial Evaluation of a Novel Bone-Targeting Bisphosphonate-Ciprofloxacin Conjugate for the Treatment of Osteomyelitis Biofilms
P478volume60

Reverse relations

cites work (P2860)
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Q50300911Bisphosphonate-Linked TrkB Agonist: Cochlea-Targeted Delivery of a Neurotrophic Agent as a Strategy for the Treatment of Hearing Loss
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Q38667546Development of Bone Targeting Drugs.
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Q48262033Interactions between Clinically Used Bisphosphonates and Bone Mineral: from Coordination Chemistry to Biomedical Applications and Beyond.
Q99591269Poly(Aspartic Acid) Functionalized Poly(ϵ-Caprolactone) Microspheres with Enhanced Hydroxyapatite Affinity as Bone Targeting Antibiotic Carriers
Q61800644Potential of Biocellulose Carrier Impregnated with Essential Oils to Fight Against Biofilms Formed on Hydroxyapatite
Q97542685The McKenna reaction - avoiding side reactions in phosphonate deprotection

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