Resensitization of breast cancer cells to anoikis by tropomyosin-1: role of Rho kinase-dependent cytoskeleton and adhesion

scientific article published on December 2005

Resensitization of breast cancer cells to anoikis by tropomyosin-1: role of Rho kinase-dependent cytoskeleton and adhesion is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1026343986
P356DOI10.1038/SJ.ONC.1208993
P698PubMed publication ID16170368
P5875ResearchGate publication ID7594132

P2093author name stringG L Prasad
Shantaram Bharadwaj
Rita Falcioni
Giulia Bon
Ruchi Thanawala
P2860cites workHost microenvironment in breast cancer development: epithelial-cell-stromal-cell interactions and steroid hormone action in normal and cancerous mammary glandQ21195180
Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscleQ24320026
Rho-stimulated contractility drives the formation of stress fibers and focal adhesionsQ24671788
Tumour-stromal interactions. Integrins and cell adhesions as modulators of mammary cell survival and transformation.Q24801520
Host microenvironment in breast cancer development: extracellular matrix-stromal cell contribution to neoplastic phenotype of epithelial cells in the breastQ24803379
Actin binding proteins: regulation of cytoskeletal microfilamentsQ28187118
p16(MTS-1/CDKN2/INK4a) in cancer progressionQ28203438
Putting tumours in contextQ28207789
Anoikis mechanismsQ28215553
A cDNA encoding a muscle-type tropomyosin cloned from a human epithelial cell line: identity with human fibroblast tropomyosin TM1Q28286557
Spatial and temporal changes in Bax subcellular localization during anoikisQ28507532
Transforming growth factor-alpha prevents detachment-induced inhibition of c-Src kinase activity, Bcl-XL down-regulation, and apoptosis of intestinal epithelial cellsQ28580989
Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkBQ28589970
Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extensionQ28591494
Get a ligand, get a life: integrins, signaling and cell survivalQ28645744
Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane culturesQ29547700
Inhibition of c-Abl tyrosine kinase activity by filamentous actinQ30168272
Bidirectional signaling between the cytoskeleton and integrinsQ33597380
Biochemical pathways of caspase activation during apoptosisQ33804316
N terminus is essential for tropomyosin functions: N-terminal modification disrupts stress fiber organization and abolishes anti-oncogenic effects of tropomyosin-1.Q42832429
Use and properties of ROCK-specific inhibitor Y-27632.Q42834896
Switch from alphavbeta5 to alphavbeta6 integrin expression protects squamous cell carcinomas from anoikisQ42915643
Tropomyosin-1, a novel suppressor of cellular transformation is downregulated by promoter methylation in cancer cellsQ44028249
Loss of expression of tropomyosin-1, a novel class II tumor suppressor that induces anoikis, in primary breast tumorsQ44588824
Rapid onset of apoptosis in vitro follows disruption of beta 1-integrin/matrix interactions in human colonic crypt cells.Q52523025
Acquisition of anoikis resistance is a critical step in the progression of oral tongue cancer.Q52831403
Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction.Q53365686
Structural interactions between actin, tropomyosin, caldesmon and calcium binding protein and the regulation of smooth muscle thin filaments.Q53939171
The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini.Q53956406
Bcl-2 prolongs cell survival after Bax-induced release of cytochrome cQ59055150
Expression and ligand binding of α2β1 integrin on breast carcinoma cellsQ71863511
Actin dynamics: tropomyosin provides stabilityQ74604769
Focal adhesions - the cytoskeletal connectionQ33840319
Integrins and actin filaments: reciprocal regulation of cell adhesion and signalingQ33912951
Structural cues from the tissue microenvironment are essential determinants of the human mammary epithelial cell phenotypeQ33923783
AnoikisQ33978500
Human MCF10A mammary epithelial cells undergo apoptosis following actin depolymerization that is independent of attachment and rescued by Bcl-2.Q34012268
The collagen receptor integrins have distinct ligand recognition and signaling functionsQ34017807
Cytoskeletal changes in cell transformation and tumorigenesisQ34132826
Alterations in tropomyosin isoform expression in human transitional cell carcinoma of the urinary bladderQ34314756
The alpha 6 beta 4 integrin and epithelial cell migrationQ34360573
Regulation of nucleocytoplasmic trafficking by cell adhesion receptors and the cytoskeletonQ34403933
The p42/p44 MAP kinase pathway prevents apoptosis induced by anchorage and serum removalQ34699388
ADF/cofilin and actin dynamics in diseaseQ35032074
Analysis of the transcriptional program induced by Raf in epithelial cellsQ35078119
Integrin signaling to the actin cytoskeleton.Q35547365
Regulation of Bcl-2 proteins during anoikis and amorphosis.Q35832745
Integrin signalling during tumour progressionQ35906078
Integrins, oncogenes, and anchorage independence.Q36276579
A novel function for the tumor suppressor p16(INK4a): induction of anoikis via upregulation of the alpha(5)beta(1) fibronectin receptorQ36293774
Integrin-mediated adhesion regulates ERK nuclear translocation and phosphorylation of Elk-1Q36316614
Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility.Q36322135
Integrin-mediated survival signals regulate the apoptotic function of Bax through its conformation and subcellular localization.Q36328358
Matrix attachment regulates Fas-induced apoptosis in endothelial cells: a role for c-flip and implications for anoikisQ36376466
Expression of transduced tropomyosin 1 cDNA suppresses neoplastic growth of cells transformed by the ras oncogeneQ36447654
Rho-stimulated contractility contributes to the fibroblastic phenotype of Ras-transformed epithelial cellsQ36945360
Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motilityQ39714519
Active ERK/MAP kinase is targeted to newly forming cell-matrix adhesions by integrin engagement and v-SrcQ39922817
Alpha 3 beta 1 integrin promotes keratinocyte cell survival through activation of a MEK/ERK signaling pathwayQ40530851
Hypoxia-induced vascular endothelial growth factor transcription and protection from apoptosis are dependent on alpha6beta1 integrin in breast carcinoma cellsQ40534945
Regulation of anoikis by Cdc42 and Rac1.Q40565418
Activated Src increases adhesion, survival and alpha2-integrin expression in human breast cancer cellsQ40615077
Cripto-1 overexpression leads to enhanced invasiveness and resistance to anoikis in human MCF-7 breast cancer cellsQ40621911
Alpha 4 integrin increases anoikis of human osteosarcoma cellsQ40666685
Suppression of the transformed phenotype of breast cancer by tropomyosin-1.Q40706429
Increased Bcl-xL expression mediates v-Src-induced resistance to anoikis in intestinal epithelial cellsQ40735835
Integrin alphavbeta3 promotes anchorage-dependent apoptosis in human intestinal carcinoma cellsQ40787003
In an adhesion dependent human gastric adenocarcinoma cell line, integrin ligation without adhesion rescues from anoikis but is not sufficient for cell cycle progressionQ40791069
Rac1 protects epithelial cells against anoikisQ40803889
Cytoskeletal organization in tropomyosin-mediated reversion of ras-transformation: Evidence for Rho kinase pathwayQ40804659
Possible involvement of the inactivation of the Rho-Rho-kinase pathway in oncogenic Ras-induced transformation.Q40982902
Formation of actin stress fibers and focal adhesions enhanced by Rho-kinaseQ41126637
Tropomyosin isoforms in nonmuscle cells.Q41322774
Elevated levels of the alpha 5 beta 1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cellsQ41740694
LIM kinase and Diaphanous cooperate to regulate serum response factor and actin dynamicsQ42019507
The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cellsQ42481082
Polycystin-2 associates with tropomyosin-1, an actin microfilament componentQ42806465
Suppression of src-induced transformed phenotype by expression of tropomyosin-1.Q42816835
P433issue56
P407language of work or nameEnglishQ1860
P921main subjectcytoskeletonQ154626
P304page(s)8291-8303
P577publication date2005-12-01
P1433published inOncogeneQ1568657
P1476titleResensitization of breast cancer cells to anoikis by tropomyosin-1: role of Rho kinase-dependent cytoskeleton and adhesion
P478volume24