New resistance-associated substitutions and failure of dual oral therapy with daclatasvir and asunaprevir.

scientific article published on 11 January 2017

New resistance-associated substitutions and failure of dual oral therapy with daclatasvir and asunaprevir. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00535-016-1303-0
P698PubMed publication ID28078469

P50authorSeiichi MawatariQ88949828
P2093author name stringKohei Oda
Tsutomu Tamai
Akihiro Moriuchi
Akio Ido
Hirofumi Uto
Takeshi Hori
Kazuaki Tabu
Kotaro Kumagai
Yukiko Inada
Yasunari Hiramine
Kunio Fujisaki
Haruka Sakae
Oki Taniyama
Akiko Saishoji
Dai Imanaka
Takeshi Kure
Masafumi Hashiguchi
Sho Ijuin
Akihiko Oshige
P2860cites workAll-oral daclatasvir plus asunaprevir for hepatitis C virus genotype 1b: a multinational, phase 3, multicohort studyQ42202767
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Simeprevir with peginterferon/ribavirin for treatment-naïve hepatitis C genotype 1 patients in Japan: CONCERTO-1, a phase III trialQ42224933
Once-daily simeprevir with peginterferon and ribavirin for treatment-experienced HCV genotype 1-infected patients in Japan: the CONCERTO-2 and CONCERTO-3 studiesQ42231673
Deep sequencing analysis of variants resistant to the non-structural 5A inhibitor daclatasvir in patients with genotype 1b hepatitis C virus infectionQ42232746
Sequence variation in hepatitis C virus nonstructural protein 5A predicts clinical outcome of pegylated interferon/ribavirin combination therapyQ42978970
Comprehensive analysis for viral elements and interleukin-28B polymorphisms in response to pegylated interferon plus ribavirin therapy in hepatitis C virus 1B infectionQ42980276
Predictive factors of virological non-response to interferon-ribavirin combination therapy for patients infected with hepatitis C virus of genotype 1b and high viral load.Q42996720
Pre-treatment prediction of response to pegylated-interferon plus ribavirin for chronic hepatitis C using genetic polymorphism in IL28B and viral factorsQ43031629
Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in humans: in vitro and in vivo correlations.Q43039341
Telaprevir with peginterferon and ribavirin for treatment-naive patients chronically infected with HCV of genotype 1 in JapanQ43039581
CD8+ T-cell interaction with HCV replicon cells: evidence for both cytokine- and cell-mediated antiviral activity.Q43048298
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Rapid, Sensitive, and Accurate Evaluation of Drug Resistant Mutant (NS5A-Y93H) Strain Frequency in Genotype 1b HCV by Invader AssayQ28548426
IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapyQ29614896
Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis CQ29619541
Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infectionQ29620702
Correlation between mutations in the interferon sensitivity-determining region of NS5A protein and viral load of hepatitis C virus subtypes 1b, 1c, and 2aQ30757296
Portal pressure predicts outcome and safety of antiviral therapy in cirrhotic patients with hepatitis C virus infectionQ33394468
Resistance analysis of the hepatitis C virus NS5A inhibitor BMS-790052 in an in vitro replicon systemQ34022926
A novel simple assay system to quantify the percent HCV-RNA levels of NS5A Y93H mutant strains and Y93 wild-type strains relative to the total HCV-RNA levels to determine the indication for antiviral therapy with NS5A inhibitorsQ34513827
Prevalence of hepatitis C virus variants resistant to NS3 protease inhibitors or the NS5A inhibitor (BMS-790052) in hepatitis patients with genotype 1b.Q34638767
Daclatasvir plus asunaprevir for chronic HCV genotype 1b infectionQ35044909
Vaniprevir plus peginterferon alfa-2a and ribavirin in treatment-experienced Japanese patients with hepatitis C virus genotype 1 infection: a randomized phase II studyQ35055427
Safety and Efficacy of Simeprevir/Sofosbuvir in Hepatitis C-Infected Patients With Compensated and Decompensated CirrhosisQ35995534
Efficacy and safety of telaprevir, a new protease inhibitor, for difficult-to-treat patients with genotype 1 chronic hepatitis CQ36371508
Treatment of chronic hepatitis C virus infection in Japan: update on therapy and guidelinesQ36973392
Daclatasvir with sofosbuvir and ribavirin for hepatitis C virus infection with advanced cirrhosis or post-liver transplantation recurrenceQ37349067
Resistance to direct antiviral agents in patients with hepatitis C virus infectionQ37652739
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Hepatitis C: viral and host factors associated with non-response to pegylated interferon plus ribavirin.Q37772959
Impact of Pre-existing NS5A-L31 or -Y93H Minor Variants on Response Rates in Patients Infected with HCV Genotype-1b Treated with Daclatasvir/AsunaprevirQ38391487
Efficacy of daclatasvir/asunaprevir according to resistance-associated variants in chronic hepatitis C with genotype 1.Q38861177
Prevalence of Resistance-Associated Substitutions in HCV NS5A, NS5B, or NS3 and Outcomes of Treatment With Ledipasvir and SofosbuvirQ39687020
Development of rare resistance-associated variants that are extremely tolerant against NS5A inhibitors during daclatasvir/asunaprevir therapy by a two-hit mechanism.Q40791170
Relationships between serum asunaprevir concentration and alanine aminotransferase elevation during daclatasvir plus asunaprevir for chronic HCV genotype 1b infection.Q41041935
Ledipasvir and sofosbuvir fixed-dose combination with and without ribavirin for 12 weeks in treatment-naive and previously treated Japanese patients with genotype 1 hepatitis C: an open-label, randomised, phase 3 trialQ41343312
Treatment with ledipasvir and sofosbuvir improves patient-reported outcomes: Results from the ION-1, -2, and -3 clinical trialsQ42173527
Naturally occurring, resistance-associated hepatitis C virus NS5A variants are linked to interleukin-28B genotype and are sensitive to interferon-based therapyQ42175503
P433issue7
P921main subjectdaclatasvirQ5207712
P304page(s)855-867
P577publication date2017-01-11
P1433published inJournal of GastroenterologyQ15764399
P1476titleNew resistance-associated substitutions and failure of dual oral therapy with daclatasvir and asunaprevir
P478volume52

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cites work (P2860)
Q64074565Impact of novel NS5A resistance-associated substitutions of hepatitis C virus detected in treatment-experienced patients
Q47657221Systematic review with meta-analysis: effectiveness and tolerability of interferon-free direct-acting antiviral regimens for chronic hepatitis C genotype 1 in routine clinical practice in Asia.
Q55212538The co-existence of NS5A and NS5B resistance-associated substitutions is associated with virologic failure in Hepatitis C Virus genotype 1 patients treated with sofosbuvir and ledipasvir.
Q47560943The presence of multiple NS5A RASs is associated with the outcome of sofosbuvir and ledipasvir therapy in NS5A inhibitor-naïve patients with chronic HCV genotype 1b infection in a real-world cohort

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