Phenotypic improvement of dystrophic muscles by rAAV/microdystrophin vectors is augmented by Igf1 codelivery.

scientific article published on September 2005

Phenotypic improvement of dystrophic muscles by rAAV/microdystrophin vectors is augmented by Igf1 codelivery. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YMTHE.2005.04.001
P698PubMed publication ID16099410
P5875ResearchGate publication ID7661927

P50authorPaul GregorevicQ72997203
P2093author name stringJeffrey S Chamberlain
James M Allen
Simone Abmayr
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Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophyQ29619282
Complete cloning of the duchenne muscular dystrophy (DMD) cDNA and preliminary genomic organization of the DMD gene in normal and affected individualsQ30050310
Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscleQ31929653
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Functional correction of adult mdx mouse muscle using gutted adenoviral vectors expressing full-length dystrophin.Q34190967
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Systemic delivery of genes to striated muscles using adeno-associated viral vectors.Q34347199
Adeno-associated virus vector carrying human minidystrophin genes effectively ameliorates muscular dystrophy in mdx mouse modelQ35573761
Two insulin-like growth factor I messenger RNAs are expressed in human liverQ35583911
Stem cell-mediated muscle regeneration is enhanced by local isoform of insulin-like growth factor 1.Q36017254
Forced expression of dystrophin deletion constructs reveals structure-function correlations.Q36237129
Assembly of the dystrophin-associated protein complex does not require the dystrophin COOH-terminal domainQ36293809
Muscle-specific expression of insulin-like growth factor I counters muscle decline in mdx miceQ36324105
Adeno-associated virus-mediated microdystrophin expression protects young mdx muscle from contraction-induced injury.Q36968852
Conditional activation of akt in adult skeletal muscle induces rapid hypertrophyQ37574344
Regeneration of single skeletal muscle fibers in vitroQ39945884
Sequences of liver cDNAs encoding two different mouse insulin-like growth factor I precursorsQ40419087
The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factorsQ40559475
Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways.Q40767544
Dystrophin expression in muscle following gene transfer with a fully deleted ("gutted") adenovirus is markedly improved by trans-acting adenoviral gene products.Q40780142
Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factorsQ41169594
Micro-dystrophin cDNA ameliorates dystrophic phenotypes when introduced into mdx mice as a transgeneQ44020748
Functional improvement of dystrophic muscle by myostatin blockade.Q44234792
IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1.Q44853225
Administration of insulin-like growth factor-I improves fatigue resistance of skeletal muscles from dystrophic mdx mice.Q45023070
AAV vector-mediated microdystrophin expression in a relatively small percentage of mdx myofibers improved the mdx phenotypeQ45127732
Efficient transduction of skeletal muscle using vectors based on adeno-associated virus serotype 6.Q45571369
Development of multiple cloning site cis-vectors for recombinant adeno-associated virus productionQ45730844
Adeno-associated virus vector-mediated minidystrophin gene therapy improves dystrophic muscle contractile function in mdx miceQ45731049
Adeno-associated virus vector gene transfer and sarcolemmal expression of a 144 kDa micro-dystrophin effectively restores the dystrophin-associated protein complex and inhibits myofibre degeneration in nude/mdx miceQ45733070
Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vectorQ45855552
Modular flexibility of dystrophin: implications for gene therapy of Duchenne muscular dystrophyQ45883916
Balancing muscle hypertrophy and atrophyQ47413278
Targeted expression of insulin-like growth factor-I reduces early myofiber necrosis in dystrophic mdx mice.Q50487651
Adenovirus-mediated utrophin gene transfer mitigates the dystrophic phenotype of mdx mouse muscles.Q50518352
Cloning and characterization of an IGF-1 isoform expressed in skeletal muscle subjected to stretch.Q52200362
P433issue3
P304page(s)441-450
P577publication date2005-09-01
P1433published inMolecular TherapyQ15762400
P1476titlePhenotypic improvement of dystrophic muscles by rAAV/microdystrophin vectors is augmented by Igf1 codelivery
P478volume12

Reverse relations

cites work (P2860)
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