Leukotrienes as a target in asthma therapy

scientific article published on January 1994

Leukotrienes as a target in asthma therapy is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P6179Dimensions Publication ID1045622464
P356DOI10.2165/00003495-199447010-00002
P698PubMed publication ID7510618

P2093author name stringS L Johnston
N Chanarin
P2860cites workComplement receptor enhancement and chemotaxis of human neutrophils and eosinophils by leukotrienes and other lipoxygenase productsQ24681163
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Bronchial hyperreactivity to leucotriene D4 and histamine in exogenous asthmaQ34484652
Liberation of histamine and formation of lysocithin-like substances by cobra venomQ34568156
Comparative effects of inhaled leukotriene C4, leukotriene D4, and histamine in normal human subjectsQ36138245
Effect of inhaled piriprost (U-60, 257) a novel leukotriene inhibitor, on allergen and exercise induced bronchoconstriction in asthmaQ36159450
Effects of a thromboxane synthetase inhibitor (OKY-046) and a lipoxygenase inhibitor (AA-861) on bronchial responsiveness to acetylcholine in asthmatic subjectsQ36161308
Effect of a platelet activating factor antagonist, WEB 2086, on allergen induced asthmatic responsesQ36281989
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The potential roles of leukotrienes in bronchial asthmaQ37698215
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Perspectives in platelet-activating factor researchQ39663875
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Leukotrienes, LTC4 and LTB4, in bronchoalveolar lavage in bronchial asthma and other respiratory diseasesQ40773752
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Leukotriene D4 receptor blockade inhibits the immediate and late bronchoconstrictor responses to inhaled antigen in patients with asthmaQ41085264
A specific LTD4/LTE4-receptor antagonist improves pulmonary function in patients with mild, chronic asthmaQ41273463
Effect of a leukotriene antagonist, LY171883, on cold air-induced bronchoconstriction in asthmaticsQ41331562
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Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)- indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitorQ42119720
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Responses of human skin to intradermal injection of leukotrienes C4, D4 and B4.Q42636309
Pharmacological profile of leukotrienes E4, N-acetyl E4 and of four of their novel omega- and beta-oxidative metabolites in airways of guinea-pig and man in vitroQ42847351
Release of leukotrienes in patients with bronchial asthmaQ43414768
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Antagonism of antigen-induced contraction of guinea pig and human airwaysQ44487870
Inhaled corticosteroids reduce the severity of bronchial hyperresponsiveness in asthma but oral theophylline does not.Q45227522
Regional and time-dependent effects of inflammatory mediators on airway microvascular permeability in the guinea pig.Q46875964
Differential effects of calcium channel blockers on leukotriene C4- and D4-induced contractions in guinea pig pulmonary parenchymal strips.Q53873683
Reduced nonspecific bronchial reactivity and decreased airway response to antigen challenge in atopic asthmatic patients treated with the inhaled leukotriene D4 antagonist, L‐648,051Q54257704
The effect of an oral leukotriene D4 antagonist L-649,923 on the response to inhaled antigen in asthma.Q54407306
Bronchoalveolar lavage of allergic asthmatic patients following allergen bronchoprovocation.Q54430446
SLOW-REACTING SUBSTANCE OF ANAPHYLAXIS ANTAGONIST FPL 55712 IN CHRONIC ASTHMAQ57089899
Nebulization and selective deposition of LTD4in human lungsQ57638511
Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytesQ59077242
Leukotrienes are potent constrictors of human bronchiQ59082833
Local effects of synthetic leukotrienes (LTC4, LTD4, LTE4, and LTB4) in human skinQ67257989
Recovery of Leukotriene E4from the Urine of Patients with Airway ObstructionQ67491764
Urinary Excretion of Leukotriene E4and 11-dehydro-Thromboxane B2in Response to Bronchial Provocations with Allergen, Aspirin, Leukotriene D4, and Histamine in AsthmaticsQ67491772
Urinary leukotriene E4 excretion in exercise-induced asthmaQ67504515
Bronchodilator properties of an inhaled leukotriene D4 antagonist (verlukast—MK-0679) in asthmatic patientsQ68166533
Effect of cysteinyl-leukotriene receptor antagonist ICI 204.219 on allergen-induced bronchoconstriction and airway hyperreactivity in atopic subjectsQ68293935
Inhibition of exercise-induced bronchoconstriction by MK-571, a potent leukotriene D4-receptor antagonistQ68487207
The effects of a 5-lipoxygenase inhibitor on asthma induced by cold, dry airQ68613879
Characterization of inflammatory mediator release from purified human lung mast cellsQ68796353
Airway responsiveness to leukotrienes C4 and D4 and to methacholine in patients with asthma and normal controlsQ68891371
Effect of the oral leukotriene D4 antagonist LY171883 on inhaled and intradermal challenge with antigen and leukotriene D4 in atopic subjectsQ69600884
Comparative contractile responses to sulfidopeptide leukotrienes in normal and asthmatic human subjectsQ69829869
Synthesis and release of leukotriene C4 by human eosinophilsQ70157917
Time course of change in bronchial reactivity with an inhaled corticosteroid in asthmaQ70185502
Effects of leukotrienes C4 and D4 on glycoprotein and lysozyme secretion by human bronchial mucosaQ70259755
Plasma levels of leukotrienes C4 and D4 during wheezing attack in asthmatic patientsQ70359606
Slow-reacting substances, leukotrienes C4 and D4, increase the release of mucus from human airways in vitroQ70469921
Effect of a leukotriene antagonist, ONO-1078, on bronchial hyperresponsiveness in patients with asthmaQ70726803
Leukotriene-C4 enhances mucus production from submucosal glands in canine trachea in vivoQ71144621
Effects of leukotriene D on the airways in asthmaQ71655873
Bronchoconstriction produced in man by leukotrienes C and DQ72477086
P433issue1
P921main subjectasthmaQ35869
P304page(s)12-24
P577publication date1994-01-01
P1433published inDrugsQ3040094
P1476titleLeukotrienes as a target in asthma therapy
P478volume47

Reverse relations

cites work (P2860)
Q45088961A pilot study of zafirlukast as an anti-inflammatory agent in the treatment of adults with cystic fibrosis
Q38965222Boswellic Acids and Their Role in Chronic Inflammatory Diseases
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Q77421066[Potential importance of antileukotrienes in the treatment of asthma and other inflammatory diseases: apropos of a new pharmacological class]
Q51614941β-Boswellic acid, a bioactive substance used in food supplements, inhibits protein synthesis by targeting the ribosomal machinery.

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